Transcriptional regulation of Yersinia pestis biofilm formation.

Abstract:

:Yersinia pestis, the causative agent of plague, is transmitted primarily by infected fleas in nature. Y. pestis can produce biofilms that block flea's proventriculus and promote flea-borne transmission. Transcriptional regulation of Y. pestis biofilm formation plays an important role in the response to complex changes in environments, including temperature, pH, oxidative stress, and restrictive nutrition conditions, and contributes to Y. pestis growth, reproduction, transmission, and pathogenesis. A set of transcriptional regulators involved in Y. pestis biofilm production simultaneously controls a variety of biological functions and physiological pathways. Interactions between these regulators contribute to the development of Y. pestis gene regulatory networks, which are helpful for a quick response to complex environmental changes and better survival. The roles of crucial factors and regulators involved in response to complex environmental signals and Y. pestis biofilm formation as well as the precise gene regulatory networks are discussed in this review, which will give a better understanding of the complicated mechanisms of transcriptional regulation in Y. pestis biofilm formation.

journal_name

Microb Pathog

journal_title

Microbial pathogenesis

authors

Liu L,Zheng S

doi

10.1016/j.micpath.2019.04.011

subject

Has Abstract

pub_date

2019-06-01 00:00:00

pages

212-217

eissn

0882-4010

issn

1096-1208

pii

S0882-4010(18)31910-7

journal_volume

131

pub_type

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