Chlamydia pneumoniae facilitates monocyte adhesion to endothelial and smooth muscle cells.

Abstract:

:Chlamydia pneumoniae has been linked to atherosclerotic heart disease. However, there is a limited knowledge by which C. pneumoniae gain access to atheromatous lesions. The adhesion of C. pneumoniae -infected circulatory component(s) to endothelium and smooth muscle cells represents the first step in an inflammatory response. We examined the ability of viable as well as heat inactivated C. pneumoniae to infect human monocytes and subsequently the ability of infected monocytes to adhere to human coronary artery endothelial cells (HCAEC) and human coronary smooth muscle cells (HCSMC). Our results demonstrate susceptibility of monocytes to in vitro chlamydial infection. Inclusions of varying sizes and intensities were observed 3-5 days after inoculation with viable C. pneumoniae. Monocytes infected with heat inactivated organisms revealed no inclusions, in keeping with the observations of uninfected monocytes. Moreover, monocytes infected with viable C. pneumoniae adhered preferentially to HCAEC and HCSMC, as compared to uninfected monocytes or monocytes harbouring heat inactivated Chlamydia.

journal_name

Microb Pathog

journal_title

Microbial pathogenesis

authors

Kaul R,Wenman WM

doi

10.1006/mpat.2000.0420

subject

Has Abstract

pub_date

2001-03-01 00:00:00

pages

149-55

issue

3

eissn

0882-4010

issn

1096-1208

pii

S0882-4010(00)90420-0

journal_volume

30

pub_type

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