Abstract：
:Loxoscelism (the term used to define accidents by the bite of brown spiders) has been reported worldwide. Clinical manifestations following brown spider bites are frequently associated with skin degeneration, a massive inflammatory response at the injured region, intravascular hemolysis, platelet aggregation causing thrombocytopenia and renal disturbances. The mechanisms by which the venom exerts its noxious effects are currently under investigation. The whole venom is a complex mixture of toxins enriched with low molecular mass proteins in the range of 5-40 kDa. Toxins including alkaline phosphatase, hyaluronidase, metalloproteases (astacin-like proteases), low molecular mass (5.6-7.9 kDa) insecticidal peptides and phospholipases-D (dermonecrotic toxins) have been identified in the venom. The purpose of the present review is to describe biotechnological applications of whole venom or some toxins, with especial emphasis upon molecular biology findings obtained in the last years.
journal_name
Biotechnol Advjournal_title
Biotechnology advancesauthors
Senff-Ribeiro A,Henrique da Silva P,Chaim OM,Gremski LH,Paludo KS,Bertoni da Silveira R,Gremski W,Mangili OC,Veiga SSdoi
10.1016/j.biotechadv.2007.12.003subject
Has Abstractpub_date
2008-05-01 00:00:00pages
210-8issue
3eissn
0734-9750issn
1873-1899pii
S0734-9750(07)00136-Xjournal_volume
26pub_type
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