abstract：:Food additives and colorants are extensively used in the food industry to improve food quality and safety during processing, storage and packing. Sourcing of these molecules is predominately through three means: extraction from natural sources, chemical synthesis, and bio-production, with the first two being the most ...

journal_title：Biotechnology advances

authors： Sun L,Xin F,Alper HS

更新日期：2021-01-01 00:00:00

abstract：:Surface display systems have been developed to express target molecules on almost all types of biological entities from viruses to mammalian cells and on a variety of synthetic particles. Various approaches have been developed to achieve the display of many different target molecules, aiming at several technological a...

journal_title：Biotechnology advances

authors： Ricca E,Baccigalupi L,Isticato R

更新日期：2020-12-31 00:00:00

abstract：:Plant cell suspension culture (PCSC) has emerged as a viable technology to produce plant specialized metabolites (PSM). While Taxol® and ginsenoside are two examples of successfully commercialized PCSC-derived PSM, widespread utilization of the PCSC platform has yet to be realized primarily due to a lack of understand...

journal_title：Biotechnology advances

authors： Arya SS,Rookes JE,Cahill DM,Lenka SK

更新日期：2020-12-01 00:00:00

abstract：:The Vero cell line is considered the most used continuous cell line for the production of viral vectors and vaccines. Historically, it is the first cell line that was approved by the WHO for the production of human vaccines. Comprehensive experimental data on the production of many viruses using the Vero cell line can...

journal_title：Biotechnology advances

authors： Kiesslich S,Kamen AA

更新日期：2020-11-15 00:00:00

abstract：:β-Galactosidases, an important class of glycosidases, naturally catalyze the hydrolysis of β-galactosidic bonds in oligosaccharides and polysaccharides. Traditionally, these enzymes have been used to degrade lactose in dairy products, which are beneficial for lactose-intolerant people. Attractively, β-galactosidases e...

journal_title：Biotechnology advances

authors： Lu L,Guo L,Wang K,Liu Y,Xiao M

更新日期：2020-01-01 00:00:00

abstract：:This work reviews applications of high added value molecules produced from microalgae. Older forms of valorization - health food and quality feed, polyunsaturated fatty acids, pigments, carbohydrates - are currently penetrating their markets. They are driven by desirable properties: texturer and dye for food industry,...

journal_title：Biotechnology advances

authors： Levasseur W,Perré P,Pozzobon V

更新日期：2020-01-01 00:00:00

abstract：:Enzyme immobilization is a well-known technique that allows the reuse of the biocatalyst and generally improves its stability. These improved characteristics are of fundamental importance to turn industrial biocatalysis into viable and competitive processes. The immobilization of enzymes can occur through several phys...

journal_title：Biotechnology advances

authors： Mulinari J,Oliveira JV,Hotza D

更新日期：2020-01-01 00:00:00

abstract：:Recent progress in metabolic engineering and synthetic biology has enabled the production of valuable chemicals in microbial cell factories from renewable feedstocks. High value-added aromatic compounds, most of which are traditionally chemically synthesized from petroleum-derived feedstocks, represent a large class o...

journal_title：Biotechnology advances

authors： Li M,Liu C,Yang J,Nian R,Xian M,Li F,Zhang H

更新日期：2020-01-01 00:00:00

abstract：:In the biological milieu of a cell, soluble crowding molecules and rigid confined environments strongly influence whether the protein is properly folded, intrinsically disordered proteins assemble into distinct phases, or a denatured or aggregated protein species is favored. Such crowding and confinement factors act t...

journal_title：Biotechnology advances

authors： Simpson LW,Good TA,Leach JB

更新日期：2020-01-01 00:00:00

abstract：:RNA interference (RNAi) is a biological process in which small RNA (sRNA) molecules sequence-specifically silence gene expression at the transcriptional or post-transcriptional level, either by directing inhibitory chromatin modifications or by decreasing the stability or translation potential of the targeted mRNA. Th...

journal_title：Biotechnology advances

authors： Liu S,Jaouannet M,Dempsey DA,Imani J,Coustau C,Kogel KH

更新日期：2020-01-01 00:00:00

abstract：:Worldwide, colorectal cancer (CRC) remains a major cancer type and leading cause of death. Unfortunately, current medical treatments are not sufficient due to lack of effective therapy, adverse side effects, chemoresistance and disease recurrence. In recent decades, epidemiologic observations have highlighted the asso...

journal_title：Biotechnology advances

authors： Afrin S,Giampieri F,Gasparrini M,Forbes-Hernández TY,Cianciosi D,Reboredo-Rodriguez P,Zhang J,Manna PP,Daglia M,Atanasov AG,Battino M

更新日期：2020-01-01 00:00:00

abstract：:Next generation sequencing is in the process of evolving from a technology used for research purposes to one which is applied in clinical diagnostics. Recently introduced high throughput and benchtop instruments offer fully automated sequencing runs at a lower cost per base and faster assay times. In turn, the complex...

journal_title：Biotechnology advances

authors： Hess JF,Kohl TA,Kotrová M,Rönsch K,Paprotka T,Mohr V,Hutzenlaub T,Brüggemann M,Zengerle R,Niemann S,Paust N

更新日期：2020-01-01 00:00:00

abstract：:Competitive sustainable production in industry demands new and better biocatalysts, optimized bioprocesses and cost-effective product recovery. Our review sheds light on the progress made for the individual steps towards these goals, starting with the discovery of new enzymes and their corresponding genes. The enzymes...

journal_title：Biotechnology advances

authors： Wiltschi B,Cernava T,Dennig A,Galindo Casas M,Geier M,Gruber S,Haberbauer M,Heidinger P,Herrero Acero E,Kratzer R,Luley-Goedl C,Müller CA,Pitzer J,Ribitsch D,Sauer M,Schmölzer K,Schnitzhofer W,Sensen CW,Soh J,Steine

更新日期：2020-01-01 00:00:00

abstract：:Enzymes are essential and ubiquitous biocatalysts involved in various metabolic pathways and used in many industrial processes. Here, we reframe enzymes not just as biocatalysts transforming bioproducts but also as sensitive probes for exploring the structure and composition of complex bioproducts, like meat tissue, d...

journal_title：Biotechnology advances

authors： Bourlieu C,Astruc T,Barbe S,Berrin JG,Bonnin E,Boutrou R,Hugouvieux V,Le Feunteun S,Paës G

更新日期：2020-01-01 00:00:00

abstract：:Long-chain polyunsaturated fatty acids (LC-PUFAs) especially ω-3 fatty acids provide significant health benefits for human beings. However, ω-3 LC-PUFAs cannot be synthesized de novo in mammals. Traditionally, ω-3 LC-PUFAs are extracted from marine fish, and their production depends on sea fishing, which has not met e...

journal_title：Biotechnology advances

authors： Diao J,Song X,Guo T,Wang F,Chen L,Zhang W

更新日期：2020-01-01 00:00:00

abstract：:Fungi are notoriously prolific producers of secondary metabolites including nonribosomal peptides (NRPs). The structural complexity of NRPs grants them interesting activities such as antibiotic, anti-cancer, and anti-inflammatory properties. The discovery of these compounds with attractive activities can be achieved b...

journal_title：Biotechnology advances

authors： Vassaux A,Meunier L,Vandenbol M,Baurain D,Fickers P,Jacques P,Leclère V

更新日期：2019-12-01 00:00:00

abstract：:Direct interspecies electron transfer (DIET) via electrically conductive pili (e-pili) and c-type cytochrome between acetogens and methanogens has been proposed as an essential pathway for methane production. Supplements of conductive materials have been extensively found to promote methane production in microbial ana...

journal_title：Biotechnology advances

authors： Yin Q,Wu G

更新日期：2019-12-01 00:00:00

abstract：:Additive manufacturing or 3D printing has spearheaded a revolution in the biomedical sector allowing the rapid prototyping of medical devices. The recent advancements in bioprinting technology are enabling the development of potential new therapeutic options with respect to tissue engineering and regenerative medicine...

journal_title：Biotechnology advances

authors： McCarthy RR,Ullah MW,Booth P,Pei E,Yang G

更新日期：2019-12-01 00:00:00

abstract：:A major feature of twenty-first century medical research is the development of therapeutic strategies that use 'biologics' (large molecules, usually engineered proteins) and living cells instead of, or as well as, the small molecules that were the basis of pharmacology in earlier eras. The high power of these techniqu...

journal_title：Biotechnology advances

authors： Davies JA,Ireland S,Harding S,Sharman JL,Southan C,Dominguez-Monedero A

更新日期：2019-12-01 00:00:00

abstract：:Liquid formulation of therapeutic proteins is a maturing technology. Demand for products that are easy to use in the clinic or that are amenable to self-administration make a ready to use liquid formulation desirable. Most modern liquid formulations have a simple composition; comprising a buffer, a tonicity modifier, ...

journal_title：Biotechnology advances

authors： Falconer RJ

更新日期：2019-11-15 00:00:00

abstract：:Actinomycetes are one of the most valuable sources of natural products with industrial and medicinal importance. After more than half a century of exploitation, it has become increasingly challenging to find novel natural products with useful properties as the same known compounds are often repeatedly re-discovered wh...

journal_title：Biotechnology advances

authors： Palazzotto E,Tong Y,Lee SY,Weber T

更新日期：2019-11-01 00:00:00

abstract：:Plant oil based industrial oleochemistry leads to a large side stream of crude glycerol, which offers itself as a low price carbon source for microbial chemical production. Compared to sugar, glycerol is more reduced and less microorganisms are able to use it as carbon source. An interesting feature of glycerol conver...

journal_title：Biotechnology advances

authors： Russmayer H,Egermeier M,Kalemasi D,Sauer M

更新日期：2019-11-01 00:00:00

abstract：:Phenotypic profiling of natural, engineered or synthetic cells has increasingly become a bottleneck in the mining and engineering of cell factories. Single-cell phenotyping technologies are highly promising for tackling this hurdle, yet ideally they should allow non-invasive live-cell probing, be label-free, provide l...

journal_title：Biotechnology advances

authors： He Y,Wang X,Ma B,Xu J

更新日期：2019-11-01 00:00:00

abstract：:Recently, United States Food and Drug Administration (FDA) and European Commission (EC) approved Alnylam Pharmaceuticals' RNA interference (RNAi) therapeutic, ONPATTRO™ (Patisiran), for the treatment of the polyneuropathy of hereditary transthyretin-mediated (hATTR) amyloidosis in adults. This is the first RNAi therap...

journal_title：Biotechnology advances

authors： Weng Y,Xiao H,Zhang J,Liang XJ,Huang Y

更新日期：2019-01-01 00:00:00

abstract：:Aptamers are short single-stranded nucleic acid sequences capable of binding to target molecules in a way similar to antibodies. Due to various advantages such as prolonged shelf life, low batch to batch variation, low/no immunogenicity, freedom to incorporate chemical modification for enhanced stability and targeting...

journal_title：Biotechnology advances

authors： Wang T,Chen C,Larcher LM,Barrero RA,Veedu RN

更新日期：2019-01-01 00:00:00

abstract：:Industrial biotechnology is reliant on native pathway engineering or foreign pathway introduction for efficient biosynthesis of target products. Chromosomal integration, with intrinsic genetic stability, is an indispensable step for reliable expression of homologous or heterologous genes and pathways in large-scale an...

journal_title：Biotechnology advances

authors： Li L,Liu X,Wei K,Lu Y,Jiang W

更新日期：2019-01-01 00:00:00

abstract：:The non-conventional oleaginous yeast Yarrowia lipolytica shows great industrial promise. It naturally produces certain compounds of interest but can also artificially generate non-native metabolites, thanks to an engineering process made possible by the significant expansion of a dedicated genetic toolbox. In this re...

journal_title：Biotechnology advances

authors： Larroude M,Rossignol T,Nicaud JM,Ledesma-Amaro R

更新日期：2018-12-01 00:00:00

abstract：:Human immunodeficiency virus (HIV) remains a worldwide health problem despite huge investments and research breakthroughs, and no single drug is effective in killing the virus yet. Among new strategies to control HIV infection, the phage display (PD) technology has become a promising tool in the discovery of peptides ...

journal_title：Biotechnology advances

authors： Lopes RS,Queiroz MAF,Gomes STM,Vallinoto ACR,Goulart LR,Ishak R

更新日期：2018-11-15 00:00:00

abstract：:Compared with the better-studied canonical amino acids, the distribution, metabolism and functions of natural non-canonical amino acids remain relatively obscure. Natural non-canonical amino acids have been mainly discovered in plants as secondary metabolites that perform diversified physiological functions. Due to th...

journal_title：Biotechnology advances

authors： Zou H,Li L,Zhang T,Shi M,Zhang N,Huang J,Xian M

更新日期：2018-11-15 00:00:00

abstract：:The diversity of natural compounds is essential for their mechanism of action. The source, structures and structure activity relationship of natural compounds contributed to the development of new classes of chemotherapy agents for over 40 years. The availability of combinatorial chemistry and high-throughput screenin...

journal_title：Biotechnology advances

authors： Mazumder A,Cerella C,Diederich M

更新日期：2018-11-01 00:00:00

abstract：:Differentiation of cancer cells entails the reversion of phenotype from malignant to the original. The conversion to cell type characteristic for another tissue is named transdifferentiation. Differentiation/transdifferentiation of malignant cells in high grade tumor mass could serve as a nonaggressive approach that p...

journal_title：Biotechnology advances

authors： Mijatović S,Bramanti A,Nicoletti F,Fagone P,Kaluđerović GN,Maksimović-Ivanić D

更新日期：2018-11-01 00:00:00

abstract：:Integrins are cell adhesion receptors predominantly important during normal and tumor angiogenesis. A sequence present on several extracellular matrix proteins composed of Arg-Gly-Asp (RGD) has attracted attention due to its role in cell adhesion mediated by integrins. The development of ligands that can bind to integ...

journal_title：Biotechnology advances

authors： Rocha LA,Learmonth DA,Sousa RA,Salgado AJ

更新日期：2018-01-01 00:00:00

abstract：:The impact of additive manufacturing in our lives has been increasing constantly. One of the frontiers in this change is the medical devices. 3D printing technologies not only enable the personalization of implantable devices with respect to patient-specific anatomy, pathology and biomechanical properties but they als...

journal_title：Biotechnology advances

authors： Nagarajan N,Dupret-Bories A,Karabulut E,Zorlutuna P,Vrana NE

更新日期：2018-01-01 00:00:00

abstract：:Silver was widely used in medicine to treat bacterial infections in the 19th and early 20th century, up until the discovery and development of the first modern antibiotics in the 1940s, which were markedly more effective. Since then, every new antibiotic introduced to the clinic has led to an associated development of...

journal_title：Biotechnology advances

authors： Möhler JS,Sim W,Blaskovich MAT,Cooper MA,Ziora ZM

更新日期：2018-01-01 00:00:00

abstract：:A rapidly growing body of experimental evidence has begun to shed light on the wide ranging molecular mechanisms which modulate intra- and inter-cellular communications. A substantial quantity of the available knowledge has only been uncovered in recent years, and we are learning that donor cells release nanovesicles,...

journal_title：Biotechnology advances

authors： Farooqi AA,Desai NN,Qureshi MZ,Librelotto DRN,Gasparri ML,Bishayee A,Nabavi SM,Curti V,Daglia M

更新日期：2018-01-01 00:00:00

abstract：:Due to concerns about the unsustainability and predictable shortage of fossil feedstocks, research efforts are currently being made to develop new processes for production of commodities using alternative feedstocks. 3-Hydroxypropionic acid (CAS 503-66-2) was recognised by the US Department of Energy as one of the mos...

journal_title：Biotechnology advances

authors： de Fouchécour F,Sánchez-Castañeda AK,Saulou-Bérion C,Spinnler HÉ

更新日期：2018-01-01 00:00:00

abstract：:Herbal remedies were the first medicines used by humans due to the many pharmacologically active secondary metabolites produced by plants. Some of these metabolites inhibit cell division and can therefore be used for the treatment of cancer, e.g. the mitostatic drug paclitaxel (Taxol). The ability of plants to produce...

journal_title：Biotechnology advances

authors： Buyel JF

更新日期：2018-01-01 00:00:00

abstract：:Within five years, the CRISPR-Cas system has emerged as the dominating tool for genome engineering, while also changing the speed and efficiency of metabolic engineering in conventional (Saccharomyces cerevisiae and Schizosaccharomyces pombe) and non-conventional (Yarrowia lipolytica, Pichia pastoris syn. Komagataella...

journal_title：Biotechnology advances

authors： Raschmanová H,Weninger A,Glieder A,Kovar K,Vogl T

更新日期：2018-01-01 00:00:00

abstract：:Pigments (mainly carotenoids) are important nutraceuticals known for their potent anti-oxidant activities and have been used extensively as high end health supplements. Microalgae are the most promising sources of natural carotenoids and are devoid of the toxic effects associated with synthetic derivatives. Compared t...

journal_title：Biotechnology advances

authors： Hu J,Nagarajan D,Zhang Q,Chang JS,Lee DJ

更新日期：2018-01-01 00:00:00

abstract：:Circulating tumor cells (CTCs) are a major contributor of cancer metastases and hold a promising prognostic significance in cancer detection. Performing functional and molecular characterization of CTCs provides an in-depth knowledge about this lethal disease. Researchers are making efforts to design devices and devel...

journal_title：Biotechnology advances

authors： Sharma S,Zhuang R,Long M,Pavlovic M,Kang Y,Ilyas A,Asghar W

更新日期：2018-01-01 00:00:00