Abstract：
:Vaccines represent a special class of drugs, capable of stimulating immune system responses against pathogens and tumors. Vaccine development is a lengthy process that includes expensive laboratory experiments in order to assess safety and effectiveness. As the efficacy of a vaccine was demonstrated by biological/chemical investigations and pre-clinical studies, then a major problem is represented by the search for an optimal vaccination dosage. Optimality here assumes the meaning of assuring a high degree of efficacy and safety (lack of toxic or side effects). In lack of quantitative methods, this is usually achieved by a consensus technique, a public statement on a particular aspect of medical knowledge available at the time it was written, and that is generally agreed upon as the evidence-based, state-of-the-art (or state-of-science) knowledge by a representative group of experts in that area. In this article, we focus on the difficult problem of the search for an optimal vaccination dosage in the field of tumor immunology, that is a major issue in biomedical research. This, indeed, represents a first step toward a personalized medicine approach.
journal_name
Biotechnol Advjournal_title
Biotechnology advancesauthors
Pappalardo F,Pennisi M,Castiglione F,Motta Sdoi
10.1016/j.biotechadv.2009.10.001subject
Has Abstractpub_date
2010-01-01 00:00:00pages
82-93issue
1eissn
0734-9750issn
1873-1899pii
S0734-9750(09)00179-7journal_volume
28pub_type
杂志文章,评审abstract：:Although the history of the golden spice turmeric (Curcuma longa) goes back thousands of years, it is only within the past century that we learned about the chemistry of its active component, curcumin. More than 6000 articles published within the past two decades have discussed the molecular basis for the antioxidant,...
journal_title：Biotechnology advances
pub_type： 杂志文章,评审
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journal_title：Biotechnology advances
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journal_title：Biotechnology advances
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journal_title：Biotechnology advances
pub_type： 杂志文章,评审
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journal_title：Biotechnology advances
pub_type： 杂志文章,评审
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journal_title：Biotechnology advances
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journal_title：Biotechnology advances
pub_type： 杂志文章,评审
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journal_title：Biotechnology advances
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journal_title：Biotechnology advances
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journal_title：Biotechnology advances
pub_type： 杂志文章,评审
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journal_title：Biotechnology advances
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journal_title：Biotechnology advances
pub_type： 杂志文章,评审
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journal_title：Biotechnology advances
pub_type： 杂志文章,评审
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更新日期：2019-01-01 00:00:00
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journal_title：Biotechnology advances
pub_type： 杂志文章,评审
doi：10.1016/j.biotechadv.2008.10.007
更新日期：2009-03-01 00:00:00
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journal_title：Biotechnology advances
pub_type： 杂志文章,评审
doi：10.1016/j.biotechadv.2019.05.001
更新日期：2019-11-01 00:00:00
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journal_title：Biotechnology advances
pub_type： 杂志文章,评审
doi：10.1016/j.biotechadv.2013.07.003
更新日期：2013-11-15 00:00:00
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journal_title：Biotechnology advances
pub_type： 杂志文章,评审
doi：10.1016/j.biotechadv.2013.02.010
更新日期：2013-11-01 00:00:00
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pub_type： 杂志文章,评审
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journal_title：Biotechnology advances
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journal_title：Biotechnology advances
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journal_title：Biotechnology advances
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journal_title：Biotechnology advances
pub_type： 杂志文章,评审
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journal_title：Biotechnology advances
pub_type： 杂志文章,评审
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journal_title：Biotechnology advances
pub_type： 杂志文章
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journal_title：Biotechnology advances
pub_type： 杂志文章,评审
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journal_title：Biotechnology advances
pub_type： 杂志文章,评审
doi：10.1016/j.biotechadv.2009.01.012
更新日期：2009-07-01 00:00:00
