Abstract：
:The impact of additive manufacturing in our lives has been increasing constantly. One of the frontiers in this change is the medical devices. 3D printing technologies not only enable the personalization of implantable devices with respect to patient-specific anatomy, pathology and biomechanical properties but they also provide new opportunities in related areas such as surgical education, minimally invasive diagnosis, medical research and disease models. In this review, we cover the recent clinical applications of 3D printing with a particular focus on implantable devices. The current technical bottlenecks in 3D printing in view of the needs in clinical applications are explained and recent advances to overcome these challenges are presented. 3D printing with cells (bioprinting); an exciting subfield of 3D printing, is covered in the context of tissue engineering and regenerative medicine and current developments in bioinks are discussed. Also emerging applications of bioprinting beyond health, such as biorobotics and soft robotics, are introduced. As the technical challenges related to printing rate, precision and cost are steadily being solved, it can be envisioned that 3D printers will become common on-site instruments in medical practice with the possibility of custom-made, on-demand implants and, eventually, tissue engineered organs with active parts developed with biorobotics techniques.
journal_name
Biotechnol Advjournal_title
Biotechnology advancesauthors
Nagarajan N,Dupret-Bories A,Karabulut E,Zorlutuna P,Vrana NEdoi
10.1016/j.biotechadv.2018.02.004subject
Has Abstractpub_date
2018-01-01 00:00:00pages
521-533issue
2eissn
0734-9750issn
1873-1899pii
S0734-9750(18)30020-Xjournal_volume
36pub_type
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