Different strategies to overcome multidrug resistance in cancer.

Abstract:

:The risk of acquisition of resistance to chemotherapy remains a major hurdle in the management of various types of cancer patients. Several cellular and noncellular mechanisms are involved in developing both intrinsic and acquired resistance in cancer cells toward chemotherapy. This review covers the various multidrug resistance (MDR) mechanisms observed in cancer cells as well as the various strategies developed to overcome these MDR mechanisms. Extensive studies have been conducted during the last several decades to enhance the efficacy of chemotherapy by suppressing or evading these MDR mechanisms including the use of new anticancer drugs that could escape from the efflux reaction, MDR modulators or chemosensitizers, multifunctional nanocarriers, and RNA interference (RNAi) therapy.

journal_name

Biotechnol Adv

journal_title

Biotechnology advances

authors

Saraswathy M,Gong S

doi

10.1016/j.biotechadv.2013.06.004

subject

Has Abstract

pub_date

2013-12-01 00:00:00

pages

1397-407

issue

8

eissn

0734-9750

issn

1873-1899

pii

S0734-9750(13)00110-9

journal_volume

31

pub_type

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