Abstract:
:The non-conventional oleaginous yeast Yarrowia lipolytica shows great industrial promise. It naturally produces certain compounds of interest but can also artificially generate non-native metabolites, thanks to an engineering process made possible by the significant expansion of a dedicated genetic toolbox. In this review, we present recently developed synthetic biology tools that facilitate the manipulation of Y. lipolytica, including 1) DNA assembly techniques, 2) DNA parts for constructing expression cassettes, 3) genome-editing techniques, and 4) computational tools.
journal_name
Biotechnol Advjournal_title
Biotechnology advancesauthors
Larroude M,Rossignol T,Nicaud JM,Ledesma-Amaro Rdoi
10.1016/j.biotechadv.2018.10.004subject
Has Abstractpub_date
2018-12-01 00:00:00pages
2150-2164issue
8eissn
0734-9750issn
1873-1899pii
S0734-9750(18)30167-8journal_volume
36pub_type
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