Abstract：
:Human immunodeficiency virus (HIV) remains a worldwide health problem despite huge investments and research breakthroughs, and no single drug is effective in killing the virus yet. Among new strategies to control HIV infection, the phage display (PD) technology has become a promising tool in the discovery of peptides that can be used as new drugs, or also as possible vaccine candidates. This review discusses basic aspects of PD and its use to advance two main objectives related to combating HIV-1 infection: the identification of peptides that inhibit virus replication and the identification of peptides that induce the production of neutralizing antibodies. We will cover the different approaches used for mapping and selection of mimotopes, and discuss the promising results of these biologicals as antiviral agents.
journal_name
Biotechnol Advjournal_title
Biotechnology advancesauthors
Lopes RS,Queiroz MAF,Gomes STM,Vallinoto ACR,Goulart LR,Ishak Rdoi
10.1016/j.biotechadv.2018.07.003subject
Has Abstractpub_date
2018-11-15 00:00:00pages
1847-1854issue
7eissn
0734-9750issn
1873-1899pii
S0734-9750(18)30127-7journal_volume
36pub_type
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