Fungal production of citric acid.

abstract：:Aerobic granulation is drawing increasing global interest in a quest for an efficient and innovative technology in wastewater treatment. Developed less than two decades ago, extensive research work on aerobic granulation has been reported. The instability of the granule, which is one of the main problems that hinder p...

journal_title：Biotechnology advances

authors： Lee DJ,Chen YY,Show KY,Whiteley CG,Tay JH

更新日期：2010-11-01 00:00:00

abstract：:New developments in magnetic labelling techniques for cells and microspheres have extended the useful range of magnetic separation, particularly high gradient magnetic separation, into biotechnical areas. The basic magnetic principles involved are reviewed and representative samples of labelling techniques and results...

journal_title：Biotechnology advances

authors： Dunlop EH,Feiler WA,Mattione MJ

更新日期：1984-01-01 00:00:00

abstract：:We review the recent development of mobile detection instruments used for medical diagnostics, and consider the relative advantages of approaches that utilize the internal sensing capabilities of commercially available mobile communication devices (such as smartphones and tablet computers) compared to those that utili...

journal_title：Biotechnology advances

authors： Kwon L,Long KD,Wan Y,Yu H,Cunningham BT

更新日期：2016-05-01 00:00:00

abstract：:Although rational method and global technique have been successfully applied in strain improvement respectively, the demand for engineering complex phenotypes required combinatorial approach. The technology of genome shuffling has been presented as a novel whole genome engineering approach for the rapid improvement of...

journal_title：Biotechnology advances

authors： Gong J,Zheng H,Wu Z,Chen T,Zhao X

更新日期：2009-11-01 00:00:00

abstract：:Herbal remedies were the first medicines used by humans due to the many pharmacologically active secondary metabolites produced by plants. Some of these metabolites inhibit cell division and can therefore be used for the treatment of cancer, e.g. the mitostatic drug paclitaxel (Taxol). The ability of plants to produce...

journal_title：Biotechnology advances

authors： Buyel JF

更新日期：2018-01-01 00:00:00

abstract：:Many advantages have been claimed over the years for the use of immobilised cells, both as enzyme systems and as whole viable cell systems for complete fermentation reactions. However, few of the claims have been fully substantiated, and may not even be entirely justified. Most research is involved with single applica...

journal_title：Biotechnology advances

authors： Dervakos GA,Webb C

更新日期：1991-01-01 00:00:00

abstract：:Within five years, the CRISPR-Cas system has emerged as the dominating tool for genome engineering, while also changing the speed and efficiency of metabolic engineering in conventional (Saccharomyces cerevisiae and Schizosaccharomyces pombe) and non-conventional (Yarrowia lipolytica, Pichia pastoris syn. Komagataella...

journal_title：Biotechnology advances

authors： Raschmanová H,Weninger A,Glieder A,Kovar K,Vogl T

更新日期：2018-01-01 00:00:00

abstract：:Parasitic nematodes (roundworms) of livestock have major economic impact globally. In spite of the diseases caused by these nematodes and some advances in the design of new therapeutic agents (anthelmintics) and attempts to develop vaccines against some of them, there has been limited progress in the establishment of ...

journal_title：Biotechnology advances

authors： Roeber F,Jex AR,Gasser RB

更新日期：2013-12-01 00:00:00

abstract：:The phenomenon of metal biosorption by microorganisms has been thoroughly documented. Although this phenomenon is exhibited by both living and non-living forms of biomass, the purpose of this chapter will be to review biosorption by the latter. In addition, the application of various technological processes required f...

journal_title：Biotechnology advances

authors： McHale AP,McHale S

更新日期：1994-01-01 00:00:00

abstract：:Loxoscelism (the term used to define accidents by the bite of brown spiders) has been reported worldwide. Clinical manifestations following brown spider bites are frequently associated with skin degeneration, a massive inflammatory response at the injured region, intravascular hemolysis, platelet aggregation causing t...

journal_title：Biotechnology advances

authors： Senff-Ribeiro A,Henrique da Silva P,Chaim OM,Gremski LH,Paludo KS,Bertoni da Silveira R,Gremski W,Mangili OC,Veiga SS

更新日期：2008-05-01 00:00:00

abstract：:A rapidly growing body of experimental evidence has begun to shed light on the wide ranging molecular mechanisms which modulate intra- and inter-cellular communications. A substantial quantity of the available knowledge has only been uncovered in recent years, and we are learning that donor cells release nanovesicles,...

journal_title：Biotechnology advances

authors： Farooqi AA,Desai NN,Qureshi MZ,Librelotto DRN,Gasparri ML,Bishayee A,Nabavi SM,Curti V,Daglia M

更新日期：2018-01-01 00:00:00

abstract：:An increasing number of proteins are currently available on the market as therapeutics and this branch of the pharmaceutical industry will expand substantially during the coming years. As many diseases result from dysfunction of proteins forming multicomponent complexes, protein drugs with their inherent high specific...

journal_title：Biotechnology advances

authors： Szlachcic A,Zakrzewska M,Otlewski J

更新日期：2011-07-01 00:00:00

abstract：:It has recently been discovered that a number of synthetic chemicals and naturally occurring compounds released into the environment can influence endocrine activity. These endocrine-disrupting compounds (EDCs) are highly varied in structure, provenance, and mode of action (MOA). Many EDCs are anthropogenic, products ...

journal_title：Biotechnology advances

authors： Francois E,Wang DY,Fulthorpe R,Liss SN,Edwards EA

更新日期：2003-12-01 00:00:00

abstract：:Human immunodeficiency virus (HIV) remains a worldwide health problem despite huge investments and research breakthroughs, and no single drug is effective in killing the virus yet. Among new strategies to control HIV infection, the phage display (PD) technology has become a promising tool in the discovery of peptides ...

journal_title：Biotechnology advances

authors： Lopes RS,Queiroz MAF,Gomes STM,Vallinoto ACR,Goulart LR,Ishak R

更新日期：2018-11-15 00:00:00

abstract：:A major feature of twenty-first century medical research is the development of therapeutic strategies that use 'biologics' (large molecules, usually engineered proteins) and living cells instead of, or as well as, the small molecules that were the basis of pharmacology in earlier eras. The high power of these techniqu...

journal_title：Biotechnology advances

authors： Davies JA,Ireland S,Harding S,Sharman JL,Southan C,Dominguez-Monedero A

更新日期：2019-12-01 00:00:00

abstract：:Monogenic diseases are often severe, life-threatening disorders for which lifelong palliative treatment is the only option. Over the last two decades, a number of strategies have been devised with the aim to treat these diseases with a genetic approach. Gene therapy has been under development for many years, yet suffe...

journal_title：Biotechnology advances

authors： Wong GK,Chiu AT

更新日期：2010-11-01 00:00:00

abstract：:Lactic acid, the most important hydroxycarboxylic acid, is now commercially produced by the fermentation of sugars present in biomass. In addition to its use in the synthesis of biodegradable polymers, lactic acid can be regarded as a feedstock for the green chemistry of the future. Different potentially useful chemic...

journal_title：Biotechnology advances

authors： Gao C,Ma C,Xu P

更新日期：2011-11-01 00:00:00

abstract：:The Vero cell line is considered the most used continuous cell line for the production of viral vectors and vaccines. Historically, it is the first cell line that was approved by the WHO for the production of human vaccines. Comprehensive experimental data on the production of many viruses using the Vero cell line can...

journal_title：Biotechnology advances

authors： Kiesslich S,Kamen AA

更新日期：2020-11-15 00:00:00

abstract：:The beta-lactam antibiotics have been serving mankind for over 70 years. Despite this old age, they continue to provide health to the world population by virtue of industrial production and discoveries of new secondary metabolite molecules with useful activities. Sales of these remarkable compounds have reached over $...

journal_title：Biotechnology advances

authors： Ozcengiz G,Demain AL

更新日期：2013-03-01 00:00:00

abstract：:The concept of the Truncated Light-harvesting chlorophyll Antenna (TLA) size, as a tool by which to maximize sunlight utilization and photosynthetic productivity in microalgal mass cultures or high-density plant canopies, is discussed. TLA technology is known to improve sunlight-to-product energy conversion efficienci...

journal_title：Biotechnology advances

authors： Kirst H,Melis A

更新日期：2014-01-01 00:00:00

abstract：:Cryptosporidium parvum is an obligate protozoan parasite responsible for the diarrheal illness cryptosporidiosis in humans and animals. Although C. parvum is particularly pathogenic in immunocompromised hosts, the molecular mechanisms by which C. parvum invades the host epithelial cells are not well understood. Charac...

journal_title：Biotechnology advances

authors： Boulter-Bitzer JI,Lee H,Trevors JT

更新日期：2007-01-01 00:00:00

abstract：:Gene technology has facilitated the biologization of manufacturing, i.e. the use and production of complex biological molecules and systems at an industrial scale. Monoclonal antibodies (mAbs) are currently the major class of biopharmaceutical products, but they are typically used to treat specific diseases which indi...

journal_title：Biotechnology advances

authors： Buyel JF,Twyman RM,Fischer R

更新日期：2017-07-01 00:00:00

abstract：:Plant oil based industrial oleochemistry leads to a large side stream of crude glycerol, which offers itself as a low price carbon source for microbial chemical production. Compared to sugar, glycerol is more reduced and less microorganisms are able to use it as carbon source. An interesting feature of glycerol conver...

journal_title：Biotechnology advances

authors： Russmayer H,Egermeier M,Kalemasi D,Sauer M

更新日期：2019-11-01 00:00:00

abstract：:The non-conventional oleaginous yeast Yarrowia lipolytica shows great industrial promise. It naturally produces certain compounds of interest but can also artificially generate non-native metabolites, thanks to an engineering process made possible by the significant expansion of a dedicated genetic toolbox. In this re...

journal_title：Biotechnology advances

authors： Larroude M,Rossignol T,Nicaud JM,Ledesma-Amaro R

更新日期：2018-12-01 00:00:00

abstract：:This work reviews applications of high added value molecules produced from microalgae. Older forms of valorization - health food and quality feed, polyunsaturated fatty acids, pigments, carbohydrates - are currently penetrating their markets. They are driven by desirable properties: texturer and dye for food industry,...

journal_title：Biotechnology advances

authors： Levasseur W,Perré P,Pozzobon V

更新日期：2020-01-01 00:00:00

abstract：:Biotechnological processes based on immobilized viable cells have developed rapidly over the last 30 years. For a long time, basic studies of the physiological behaviour of immobilized cells (IC) have remained in the shadow of the applications. Natural IC structures, i.e. biofilms, are being increasingly investigated ...

journal_title：Biotechnology advances

authors： Junter GA,Jouenne T

更新日期：2004-11-01 00:00:00

abstract：:Fatty acid drug discovery (FADD) is defined as the identification of novel, specialized bioactive mediators that are derived from fatty acids and have precise pharmacological/therapeutic potential. A number of reports indicate that dietary intake of omega-3 fatty acids and limited intake of omega-6 promotes overall he...

journal_title：Biotechnology advances

authors： Halade GV,Black LM,Verma MK

更新日期：2018-01-01 00:00:00

abstract：:Lactoferrin, the main iron-binding protein of milk, has biological activities that are essential for the newborn and are beneficial for adults. Given this beneficial effect, there is broad interest in exogenous sources of lactoferrin in human nutrition. Consequently, several transgenic approaches to produce lactoferri...

journal_title：Biotechnology advances

authors： Conesa C,Calvo M,Sánchez L

更新日期：2010-11-01 00:00:00

abstract：:Medicinal plants have historically proven their value as a source of molecules with therapeutic potential, and nowadays still represent an important pool for the identification of novel drug leads. In the past decades, pharmaceutical industry focused mainly on libraries of synthetic compounds as drug discovery source....

journal_title：Biotechnology advances

authors： Atanasov AG,Waltenberger B,Pferschy-Wenzig EM,Linder T,Wawrosch C,Uhrin P,Temml V,Wang L,Schwaiger S,Heiss EH,Rollinger JM,Schuster D,Breuss JM,Bochkov V,Mihovilovic MD,Kopp B,Bauer R,Dirsch VM,Stuppner H

更新日期：2015-12-01 00:00:00

abstract：:This review elaborates on the recent development of microbial sterol biotransformation systems. Particular emphasis is laid on the new enzymatic approach investigating the cleavage of sterol side chain. New developments in the area of immobilized cell system and use of organic media along with recent reviews on side c...

journal_title：Biotechnology advances

authors： Ahmad S,Garg SK,Johri BN

更新日期：1992-01-01 00:00:00