Abstract:
:The kinetic resolution of racemates and desymmetrization are the most common approaches to the preparation of enantiomerically enriched compounds. These procedures allow the access of high valuable, chiral building blocks for many purposes in academic or industrial R&D endeavors. Nevertheless, the scope of stereochemistry recognition in biotransformations usually occurs at the site of the transformation or when it is close to it (not more than 3 bonds). However, there are a growing number of enzymatic transformations which surpass the limits of stereorecognition of remote chiral (or prochiral) centers. In this account, we would like to present some aspects of biocatalyzed remote resolutions and remote desymmetrizations to call attention for these challenging transformations.
journal_name
Biotechnol Advjournal_title
Biotechnology advancesauthors
Cunha RL,Ferreira EA,Oliveira CS,Omori ÁTdoi
10.1016/j.biotechadv.2014.12.009subject
Has Abstractpub_date
2015-09-01 00:00:00pages
614-23issue
5eissn
0734-9750issn
1873-1899pii
S0734-9750(14)00196-7journal_volume
33pub_type
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