αvβ3 and α5β1 integrin-specific ligands: From tumor angiogenesis inhibitors to vascularization promoters in regenerative medicine?

abstract：:Differentiation of cancer cells entails the reversion of phenotype from malignant to the original. The conversion to cell type characteristic for another tissue is named transdifferentiation. Differentiation/transdifferentiation of malignant cells in high grade tumor mass could serve as a nonaggressive approach that p...

journal_title：Biotechnology advances

authors： Mijatović S,Bramanti A,Nicoletti F,Fagone P,Kaluđerović GN,Maksimović-Ivanić D

更新日期：2018-11-01 00:00:00

abstract：:Although the history of the golden spice turmeric (Curcuma longa) goes back thousands of years, it is only within the past century that we learned about the chemistry of its active component, curcumin. More than 6000 articles published within the past two decades have discussed the molecular basis for the antioxidant,...

journal_title：Biotechnology advances

authors： Prasad S,Gupta SC,Tyagi AK,Aggarwal BB

更新日期：2014-11-01 00:00:00

abstract：:Orchids (Orchidaceae) are one of the most diverse plant groups on the planet with over 25,000 species. For over a century, scientists and horticulturalists have been fascinated by their complex floral morphology, pollinator specificity and multiple ethnobotanical uses, including as food, flavourings, medicines, orname...

journal_title：Biotechnology advances

authors： Popova E,Kim HH,Saxena PK,Engelmann F,Pritchard HW

更新日期：2016-07-01 00:00:00

abstract：:The ubiquitous presence of allergens in the human food supply coupled with increased awareness of food allergies warrants undertaking appropriate preventive measures to protect sensitive consumers from unwanted exposure to offending food allergens. Attempts to reduce or eliminate food allergenicity through food proces...

journal_title：Biotechnology advances

authors： Sathe SK,Teuber SS,Roux KH

更新日期：2005-09-01 00:00:00

abstract：:Liquid formulation of therapeutic proteins is a maturing technology. Demand for products that are easy to use in the clinic or that are amenable to self-administration make a ready to use liquid formulation desirable. Most modern liquid formulations have a simple composition; comprising a buffer, a tonicity modifier, ...

journal_title：Biotechnology advances

authors： Falconer RJ

更新日期：2019-11-15 00:00:00

abstract：:The yeast, Saccharomyces cerevisiae is currently used for the production of recombinant DNA-generated proteins derived from a variety of eukaryotic organisms. The applications of a yeast-based technology in the production of proteins for pharmaceutical and industrial purposes is discussed including current methods for...

journal_title：Biotechnology advances

authors： Martin CE,Scheinbach S

更新日期：1989-01-01 00:00:00

abstract：:Biomass, a renewable, sustainable and carbon dioxide neutral resource, has received widespread attention in the energy market as an alternative to fossil fuels. Thermal-chemical conversion of biomass to produce biofuels is a promising technology with many commercial applications. This paper reviewed the state-of-the-a...

journal_title：Biotechnology advances

authors： Ma L,Wang T,Liu Q,Zhang X,Ma W,Zhang Q

更新日期：2012-07-01 00:00:00

abstract：:Aerobic granular sludge sequencing batch reactors (SBR) are a promising technology for treating wastewater. Increasing evidence suggests that aerobic granulation in SBRs is driven by selection pressures exerted on microorganisms. Three major selection pressures have been identified as follows: settling time, volume ex...

journal_title：Biotechnology advances

authors： Liu Y,Wang ZW,Tay JH

更新日期：2005-07-01 00:00:00

abstract：:Recent progress in metabolic engineering and synthetic biology has enabled the production of valuable chemicals in microbial cell factories from renewable feedstocks. High value-added aromatic compounds, most of which are traditionally chemically synthesized from petroleum-derived feedstocks, represent a large class o...

journal_title：Biotechnology advances

authors： Li M,Liu C,Yang J,Nian R,Xian M,Li F,Zhang H

更新日期：2020-01-01 00:00:00

abstract：:Iron is indispensible for life and essential for such processes as oxygen transport, electron transfer and DNA synthesis. Transferrin (Tf) is a ubiquitous protein with a central role in iron transport and metabolism. There is evidence, however, that Tf has many other biological roles in addition to its primary functio...

journal_title：Biotechnology advances

authors： Brandsma ME,Jevnikar AM,Ma S

更新日期：2011-03-01 00:00:00

abstract：:In addition to the nuclear genome, organisms have organelle genomes. Most of the DNA present in eukaryotic organisms is located in the cell nucleus. Chloroplasts have independent genomes which are inherited from the mother. Duplicated genes are common in the genomes of all organisms. It is believed that gene duplicati...

journal_title：Biotechnology advances

authors： Xiong AS,Peng RH,Zhuang J,Gao F,Zhu B,Fu XY,Xue Y,Jin XF,Tian YS,Zhao W,Yao QH

更新日期：2009-07-01 00:00:00

abstract：:The biotech industry is, nowadays, facing unparalleled challenges due to the enhanced demand for biotechnology-based human therapeutic products, such as monoclonal antibodies (mAbs). This has led companies to improve substantially their upstream processes, with the yield of monoclonals increasing to titers never seen ...

journal_title：Biotechnology advances

authors： Rosa PA,Azevedo AM,Sommerfeld S,Bäcker W,Aires-Barros MR

更新日期：2011-11-01 00:00:00

abstract：:RNA interference (RNAi) is a biological process in which small RNA (sRNA) molecules sequence-specifically silence gene expression at the transcriptional or post-transcriptional level, either by directing inhibitory chromatin modifications or by decreasing the stability or translation potential of the targeted mRNA. Th...

journal_title：Biotechnology advances

authors： Liu S,Jaouannet M,Dempsey DA,Imani J,Coustau C,Kogel KH

更新日期：2020-01-01 00:00:00

abstract：:Culturing of microalgae as an alternative feedstock for biofuel production has received a lot of attention in recent years due to their fast growth rate and ability to accumulate high quantity of lipid and carbohydrate inside their cells for biodiesel and bioethanol production, respectively. In addition, this superior...

journal_title：Biotechnology advances

authors： Lam MK,Lee KT

更新日期：2012-05-01 00:00:00

abstract：:In order to decrease carbon emissions and negative environmental impacts of various pollutants, biofuel/biochemical production should be promoted for replacing fossil-based industrial processes. Utilization of abundant lignocellulosic biomass as a feedstock has recently become an attractive option. In this review, we ...

journal_title：Biotechnology advances

authors： Tanaka T,Kondo A

更新日期：2015-11-15 00:00:00

abstract：:Vitrification is a new approach to oocyte and embryo cryoconservation. It consists in the solidification of a solution caused not by crystallization, but by a drastic increase in viscosity during cooling. The application of this approach to cryoconservation of oocytes and embryos of different species depends upon the ...

journal_title：Biotechnology advances

authors： Smorag Z,Gajda B

更新日期：1994-01-01 00:00:00

abstract：:In recent years, the use of surface-display vectors for displaying polypeptides on the surface of bacteriophage and bacteria, combined with in vitro selection technologies, has transformed the way in which we generate and manipulate ligands, such as enzymes, antibodies and peptides. Phage display is based on expressin...

journal_title：Biotechnology advances

authors： Benhar I

更新日期：2001-02-01 00:00:00

abstract：:The aldopentose D-xylose is one of the most abundant sugars in plant biomass and its efficient microbial utilization is of fundamental importance in the overall bioconversion of lignocellulosic materials into liquid fuels and chemicals. The discovery of pentose-fermenting yeasts in the early 1980's led to world wide i...

journal_title：Biotechnology advances

authors： Webb SR,Lee H

更新日期：1990-01-01 00:00:00

abstract：:The beta-lactam antibiotics have been serving mankind for over 70 years. Despite this old age, they continue to provide health to the world population by virtue of industrial production and discoveries of new secondary metabolite molecules with useful activities. Sales of these remarkable compounds have reached over $...

journal_title：Biotechnology advances

authors： Ozcengiz G,Demain AL

更新日期：2013-03-01 00:00:00

abstract：:The non-conventional oleaginous yeast Yarrowia lipolytica shows great industrial promise. It naturally produces certain compounds of interest but can also artificially generate non-native metabolites, thanks to an engineering process made possible by the significant expansion of a dedicated genetic toolbox. In this re...

journal_title：Biotechnology advances

authors： Larroude M,Rossignol T,Nicaud JM,Ledesma-Amaro R

更新日期：2018-12-01 00:00:00

abstract：:Although rational method and global technique have been successfully applied in strain improvement respectively, the demand for engineering complex phenotypes required combinatorial approach. The technology of genome shuffling has been presented as a novel whole genome engineering approach for the rapid improvement of...

journal_title：Biotechnology advances

authors： Gong J,Zheng H,Wu Z,Chen T,Zhao X

更新日期：2009-11-01 00:00:00

abstract：:The global biopharmaceutical market is worth over $100 billion USD. Nearly 90% of these products will lose their patent in the next ten years, leading to the commercialization of their subsequent versions, known as 'biosimilars'. Biosimilars are much more complex molecules than chemically synthesized generics in terms...

journal_title：Biotechnology advances

authors： Ibarra-Cabrera R,Mena-Pérez SC,Bondani-Guasti A,García-Arrazola R

更新日期：2013-12-01 00:00:00

abstract：:Yeast strains Y1, Y4 and Y7 demonstrated high conversion efficiencies for sugars and high abilities to tolerate or metabolize inhibitors in dilute-acid lignocellulosic hydrolysates. Strains Y1 and Y4 completely consumed the glucose within 24 h in dilute-acid lignocellulosic hydrolysate during in situ detoxification, a...

journal_title：Biotechnology advances

authors： Tian S,Zhou G,Yan F,Yu Y,Yang X

更新日期：2009-09-01 00:00:00

abstract：:For many proteins and peptides, disulfide bridges are prerequisite for their proper biological function. Many commercialized proteins are crosslinked by disulfide bridges that increase their resistance to destructive effects of extreme environment used in industrial processes or protect protein-based therapeutics from...

journal_title：Biotechnology advances

authors： Bulaj G

更新日期：2005-01-01 00:00:00

abstract：:The control of hepatitis B virus (HBV) infection is a challenging task, specifically in developing countries there is limited access to diagnostics and antiviral treatment mainly due to high costs and insufficient healthcare infrastructure. Although the current diagnostic technologies can reliably detect HBV, they are...

journal_title：Biotechnology advances

authors： Yildiz UH,Inci F,Wang S,Toy M,Tekin HC,Javaid A,Lau DT,Demirci U

更新日期：2015-01-01 00:00:00

abstract：:The review assesses current status and attempts to forecast trends in the development of lectin biorecognition technology. The progressive trend is characterized scientometrically and reflects the current transient situation, when standard low-throughput lectin-based techniques are being replaced by a novel microarray...

journal_title：Biotechnology advances

authors： Gemeiner P,Mislovicová D,Tkác J,Svitel J,Pätoprstý V,Hrabárová E,Kogan G,Kozár T

更新日期：2009-01-01 00:00:00

abstract：:In recent years the study of root phenotypic plasticity in response to sub-optimal environmental factors and the genetic control of these responses have received renewed attention. As a path to increased productivity, in particular for low fertility soils, several applied research projects worldwide target the improve...

journal_title：Biotechnology advances

authors： Postma JA,Schurr U,Fiorani F

更新日期：2014-01-01 00:00:00

abstract：:Ribosomally synthesized peptides with antimicrobial properties (antimicrobial peptides-AMPs) are produced by eukaryotes and prokaryotes and represent crucial components of their defense systems against microorganisms. Although they differ in structure, they are nearly all cationic and very often amphiphilic, which ref...

journal_title：Biotechnology advances

authors： Papagianni M

更新日期：2003-09-01 00:00:00

abstract：:Bovine chymosin, an aspartyl protease extracted from abomasum of suckling calves, is synthesized in vivo as preprochymosin and secreted as prochymosin which is autocatalytically activated to chymosin. Chymosin is bilobular, with Asp 32 and Asp 215 acting as the catalytic residues. Chymosin A and chymosin B have pH opt...

journal_title：Biotechnology advances

authors： Mohanty AK,Mukhopadhyay UK,Grover S,Batish VK

更新日期：1999-09-01 00:00:00

abstract：:Agrin and neuregulin are broadly expressed molecules that have significant developmental roles. Here we review the diverse temporal and spatial expression patterns and functions of these molecules and the impact that dysregulation may have on a number of disease states. Many know agrin as a modulator of synaptogenesis...

journal_title：Biotechnology advances

authors： Williams S,Ryan C,Jacobson C

更新日期：2008-05-01 00:00:00