Abstract：
:For many proteins and peptides, disulfide bridges are prerequisite for their proper biological function. Many commercialized proteins are crosslinked by disulfide bridges that increase their resistance to destructive effects of extreme environment used in industrial processes or protect protein-based therapeutics from rapid proteolytic degradation. Manufacturing of these products must take into account oxidative refolding--a formation of native disulfide bonds by specific pairs of cysteines located throughout a sequence of linear protein. This review describes basic and practical aspects of oxidative folding that should be considered while designing and optimizing manufacturing of proteins using chemical synthesis, semi-synthesis and a recombinant expression.
journal_name
Biotechnol Advjournal_title
Biotechnology advancesauthors
Bulaj Gdoi
10.1016/j.biotechadv.2004.09.002subject
Has Abstractpub_date
2005-01-01 00:00:00pages
87-92issue
1eissn
0734-9750issn
1873-1899pii
S0734-9750(04)00088-6journal_volume
23pub_type
杂志文章,评审abstract：:Although rational method and global technique have been successfully applied in strain improvement respectively, the demand for engineering complex phenotypes required combinatorial approach. The technology of genome shuffling has been presented as a novel whole genome engineering approach for the rapid improvement of...
journal_title：Biotechnology advances
pub_type： 杂志文章,评审
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journal_title：Biotechnology advances
pub_type： 杂志文章,评审
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journal_title：Biotechnology advances
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journal_title：Biotechnology advances
pub_type： 杂志文章,评审
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更新日期：2018-01-01 00:00:00
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journal_title：Biotechnology advances
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journal_title：Biotechnology advances
pub_type： 杂志文章,评审
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更新日期：2013-09-01 00:00:00
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journal_title：Biotechnology advances
pub_type： 杂志文章,评审
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journal_title：Biotechnology advances
pub_type： 杂志文章,评审
doi：10.1016/j.biotechadv.2018.02.002
更新日期：2018-01-01 00:00:00
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journal_title：Biotechnology advances
pub_type： 杂志文章,评审
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journal_title：Biotechnology advances
pub_type： 杂志文章,评审
doi：10.1016/j.biotechadv.2004.06.003
更新日期：2004-11-01 00:00:00
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journal_title：Biotechnology advances
pub_type： 杂志文章,评审
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更新日期：2009-07-01 00:00:00
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journal_title：Biotechnology advances
pub_type： 杂志文章,评审
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更新日期：2016-05-01 00:00:00
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journal_title：Biotechnology advances
pub_type： 杂志文章,评审
doi：10.1016/j.biotechadv.2012.08.009
更新日期：2012-11-01 00:00:00
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journal_title：Biotechnology advances
pub_type： 杂志文章,评审
doi：10.1016/j.biotechadv.2018.04.001
更新日期：2018-11-01 00:00:00
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journal_title：Biotechnology advances
pub_type： 杂志文章
doi：10.1016/0734-9750(84)90010-7
更新日期：1984-01-01 00:00:00
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journal_title：Biotechnology advances
pub_type： 杂志文章,评审
doi：10.1016/j.biotechadv.2019.107463
更新日期：2020-01-01 00:00:00
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journal_title：Biotechnology advances
pub_type： 杂志文章,评审
doi：10.1016/j.biotechadv.2018.05.004
更新日期：2018-01-01 00:00:00
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journal_title：Biotechnology advances
pub_type： 杂志文章,评审
doi：10.1016/j.biotechadv.2015.06.002
更新日期：2015-11-15 00:00:00
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journal_title：Biotechnology advances
pub_type： 杂志文章
doi：10.1016/0734-9750(91)90733-c
更新日期：1991-01-01 00:00:00
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journal_title：Biotechnology advances
pub_type： 杂志文章
doi：10.1016/0734-9750(93)90411-f
更新日期：1993-01-01 00:00:00
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journal_title：Biotechnology advances
pub_type： 杂志文章,评审
doi：10.1016/j.biotechadv.2018.11.001
更新日期：2019-01-01 00:00:00
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journal_title：Biotechnology advances
pub_type： 杂志文章
doi：10.1016/0734-9750(94)90291-7
更新日期：1994-01-01 00:00:00
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journal_title：Biotechnology advances
pub_type： 杂志文章,评审
doi：10.1016/j.biotechadv.2012.11.003
更新日期：2013-09-01 00:00:00
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journal_title：Biotechnology advances
pub_type： 杂志文章,评审
doi：10.1016/j.biotechadv.2019.04.010
更新日期：2019-11-01 00:00:00
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journal_title：Biotechnology advances
pub_type： 杂志文章,评审
doi：10.1016/j.biotechadv.2009.07.002
更新日期：2009-11-01 00:00:00
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journal_title：Biotechnology advances
pub_type： 杂志文章
doi：10.1016/s0734-9750(00)00054-9
更新日期：2001-02-01 00:00:00
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journal_title：Biotechnology advances
pub_type： 杂志文章,评审
doi：10.1016/j.biotechadv.2010.01.004
更新日期：2010-05-01 00:00:00
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journal_title：Biotechnology advances
pub_type： 杂志文章
doi：10.1016/0734-9750(94)90019-1
更新日期：1994-01-01 00:00:00
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journal_title：Biotechnology advances
pub_type： 杂志文章,评审
doi：10.1016/j.biotechadv.2013.05.010
更新日期：2013-12-01 00:00:00
abstract：:Dihydroxyacetone is extensively used in cosmetic industry as an artificial suntan besides having clinical and biological applications. Thus, it is important to meet the commercial demand of dihydroxyacetone at an economical and qualitative level. Microbial route of production is found to be more favorable for dihydrox...
journal_title：Biotechnology advances
pub_type： 杂志文章,收录出版,评审
doi：10.1016/j.biotechadv.2008.02.001
更新日期：2008-07-01 00:00:00
