Abstract：
:Biopharmaceuticals present the fastest growing segment in the pharmaceutical industry, with an ever widening scope of applications. Whole plants as well as contained plant cell culture systems are being explored for their potential as cheap, safe, and scalable production hosts. The first plant-derived biopharmaceuticals have now reached the clinic. Many biopharmaceuticals are glycoproteins; as the Golgi N-glycosylation machinery of plants differs from the mammalian machinery, the N-glycoforms introduced on plant-produced proteins need to be taken into consideration. Potent systems have been developed to change the plant N-glycoforms to a desired or even superior form compared to the native mammalian N-glycoforms. This review describes the current status of biopharmaceutical production in plants for industrial applications. The recent advances and tools which have been utilized to generate glycoengineered plants are also summarized and compared with the relevant mammalian systems whenever applicable.
journal_name
Biotechnol Advjournal_title
Biotechnology advancesauthors
Karg SR,Kallio PTdoi
10.1016/j.biotechadv.2009.07.002subject
Has Abstractpub_date
2009-11-01 00:00:00pages
879-894issue
6eissn
0734-9750issn
1873-1899pii
S0734-9750(09)00144-Xjournal_volume
27pub_type
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