Abstract：
:Iron is indispensible for life and essential for such processes as oxygen transport, electron transfer and DNA synthesis. Transferrin (Tf) is a ubiquitous protein with a central role in iron transport and metabolism. There is evidence, however, that Tf has many other biological roles in addition to its primary function of facilitating iron transport and metabolism, such as its profound effect on mammalian cell growth and productivity. The multiple functions of Tf can be exploited to develop many novel applications. Indeed, over the past several years, considerable efforts have been directed towards exploring human serum Tf (hTf), especially the use of recombinant native hTf and recombinant Tf fusion proteins, for various applications within biotechnology and medicine. Here, we review some of the remarkable progress that has been made towards the application of hTf in these diverse areas and discuss some of the exciting future prospects for hTf.
journal_name
Biotechnol Advjournal_title
Biotechnology advancesauthors
Brandsma ME,Jevnikar AM,Ma Sdoi
10.1016/j.biotechadv.2010.11.007subject
Has Abstractpub_date
2011-03-01 00:00:00pages
230-8issue
2eissn
0734-9750issn
1873-1899pii
S0734-9750(10)00164-3journal_volume
29pub_type
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