Abstract：
:Parasitic nematodes (roundworms) of livestock have major economic impact globally. In spite of the diseases caused by these nematodes and some advances in the design of new therapeutic agents (anthelmintics) and attempts to develop vaccines against some of them, there has been limited progress in the establishment of practical diagnostic techniques. The specific and sensitive diagnosis of gastrointestinal nematode infections of livestock underpins effective disease control, which is highly relevant now that anthelmintic resistance (AR) is a major problem. Traditional diagnostic techniques have major constraints, in terms of sensitivity and specificity. The purpose of this article is to provide a brief background on gastrointestinal nematodes (Strongylida) of livestock and their control; to summarize conventional methods used for the diagnosis and discuss their constraints; to review key molecular-diagnostic methods and recent progress in the development of advanced amplification-based and sequencing technologies, and their implications for epidemiological investigations and the control of parasitic diseases.
journal_name
Biotechnol Advjournal_title
Biotechnology advancesauthors
Roeber F,Jex AR,Gasser RBdoi
10.1016/j.biotechadv.2013.01.008subject
Has Abstractpub_date
2013-12-01 00:00:00pages
1135-52issue
8eissn
0734-9750issn
1873-1899pii
S0734-9750(13)00010-4journal_volume
31pub_type
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