Cell surface engineering of industrial microorganisms for biorefining applications.

abstract：:Parasitic nematodes (roundworms) of livestock have major economic impact globally. In spite of the diseases caused by these nematodes and some advances in the design of new therapeutic agents (anthelmintics) and attempts to develop vaccines against some of them, there has been limited progress in the establishment of ...

journal_title：Biotechnology advances

authors： Roeber F,Jex AR,Gasser RB

更新日期：2013-12-01 00:00:00

abstract：:Worldwide, colorectal cancer (CRC) remains a major cancer type and leading cause of death. Unfortunately, current medical treatments are not sufficient due to lack of effective therapy, adverse side effects, chemoresistance and disease recurrence. In recent decades, epidemiologic observations have highlighted the asso...

journal_title：Biotechnology advances

authors： Afrin S,Giampieri F,Gasparrini M,Forbes-Hernández TY,Cianciosi D,Reboredo-Rodriguez P,Zhang J,Manna PP,Daglia M,Atanasov AG,Battino M

更新日期：2020-01-01 00:00:00

abstract：:DNA vaccination has been widely explored to develop new, alternative and efficient vaccines for cancer immunotherapy. DNA vaccines offer several benefits such as specific targeting, use of multiple genes to enhance immunity and reduced risk compared to conventional vaccines. Rapid developments in molecular biology and...

journal_title：Biotechnology advances

authors： Iurescia S,Fioretti D,Fazio VM,Rinaldi M

更新日期：2012-01-01 00:00:00

abstract：:The present review provides up-to-date information on the occurrence and methodologies used for producing and purifying endo-β-mannanases and a comprehensive comparison of their biochemical properties. The amalgamation of biochemical, molecular and structural biology approaches which have been used for understanding e...

journal_title：Biotechnology advances

authors： Srivastava PK,Kapoor M

更新日期：2017-01-01 00:00:00

abstract：:Silk fibroin (SF) is a natural fibrous polymer with strong potential for many biomedical applications. SF has attracted interest in the field of bone tissue engineering due to its extraordinary characteristics in terms of elasticity, flexibility, biocompatibility and biodegradability. However, low osteogenic capacity ...

journal_title：Biotechnology advances

authors： Farokhi M,Mottaghitalab F,Samani S,Shokrgozar MA,Kundu SC,Reis RL,Fatahi Y,Kaplan DL

更新日期：2018-01-01 00:00:00

abstract：:Dinoflagellate microalgae are an important source of marine biotoxins. Bioactives from dinoflagellates are attracting increasing attention because of their impact on the safety of seafood and potential uses in biomedical, toxicological and pharmacological research. Here we review the potential applications of dinoflag...

journal_title：Biotechnology advances

authors： Gallardo-Rodríguez J,Sánchez-Mirón A,García-Camacho F,López-Rosales L,Chisti Y,Molina-Grima E

更新日期：2012-11-01 00:00:00

abstract：:Selenium is an essential trace element needed for all living organisms. Despite its essentiality, selenium is a potential toxic element to natural ecosystems due to its bioaccumulation potential. Though selenium is found naturally in the earth's crust, especially in carbonate rocks and volcanic and sedimentary soils, ...

journal_title：Biotechnology advances

authors： Tan LC,Nancharaiah YV,van Hullebusch ED,Lens PNL

更新日期：2016-09-01 00:00:00

abstract：:The non-conventional oleaginous yeast Yarrowia lipolytica shows great industrial promise. It naturally produces certain compounds of interest but can also artificially generate non-native metabolites, thanks to an engineering process made possible by the significant expansion of a dedicated genetic toolbox. In this re...

journal_title：Biotechnology advances

authors： Larroude M,Rossignol T,Nicaud JM,Ledesma-Amaro R

更新日期：2018-12-01 00:00:00

abstract：:Fatty acid drug discovery (FADD) is defined as the identification of novel, specialized bioactive mediators that are derived from fatty acids and have precise pharmacological/therapeutic potential. A number of reports indicate that dietary intake of omega-3 fatty acids and limited intake of omega-6 promotes overall he...

journal_title：Biotechnology advances

authors： Halade GV,Black LM,Verma MK

更新日期：2018-01-01 00:00:00

abstract：:The population of sub-Saharan Africa is at risk from multiple, poverty-related endemic diseases. HIV and malaria are the most prevalent, but they disproportionately affect different groups of people, i.e. HIV predominantly affects sexually-active adults whereas malaria has a greater impact on children and pregnant wom...

journal_title：Biotechnology advances

authors： Vamvaka E,Twyman RM,Christou P,Capell T

更新日期：2014-05-01 00:00:00

abstract：:Enormous sequence information is available in public databases as a result of sequencing of diverse crop genomes. It is important to use this genomic information for the identification and isolation of novel and superior alleles of agronomically important genes from crop gene pools to suitably deploy for the developme...

journal_title：Biotechnology advances

authors： Kumar GR,Sakthivel K,Sundaram RM,Neeraja CN,Balachandran SM,Rani NS,Viraktamath BC,Madhav MS

更新日期：2010-07-01 00:00:00

abstract：:The ability to use progenitor cells for regenerative medicine remains an evolving but elusive clinical goal. A serious obstacle towards widespread use of stem cells for tissue regeneration is the challenges that face these cells when they are placed in vivo into a wound for therapy. These environments are hypoxic, aci...

journal_title：Biotechnology advances

authors： Hyun JS,Tran MC,Wong VW,Chung MT,Lo DD,Montoro DT,Wan DC,Longaker MT

更新日期：2013-09-01 00:00:00

abstract：:For many proteins and peptides, disulfide bridges are prerequisite for their proper biological function. Many commercialized proteins are crosslinked by disulfide bridges that increase their resistance to destructive effects of extreme environment used in industrial processes or protect protein-based therapeutics from...

journal_title：Biotechnology advances

authors： Bulaj G

更新日期：2005-01-01 00:00:00

abstract：:The byproduct of cheese-producing industries, cheese whey, is considered as an environmental pollutant due to its high BOD and COD concentrations. The high organic load of whey arises from the presence of residual milk nutrients. As demand for milk-derived products is increasing, it leads to increased production of wh...

journal_title：Biotechnology advances

authors： Yadav JS,Yan S,Pilli S,Kumar L,Tyagi RD,Surampalli RY

更新日期：2015-11-01 00:00:00

abstract：:Many advantages have been claimed over the years for the use of immobilised cells, both as enzyme systems and as whole viable cell systems for complete fermentation reactions. However, few of the claims have been fully substantiated, and may not even be entirely justified. Most research is involved with single applica...

journal_title：Biotechnology advances

authors： Dervakos GA,Webb C

更新日期：1991-01-01 00:00:00

abstract：:Medicinal plants are essential for improving human health, and around 75% of the population in developing countries relies mainly on herb-based medicines for health care. As the king of herb plants, ginseng has been used for nearly 5,000 years in the oriental and recently in western medicines. Among the compounds stud...

journal_title：Biotechnology advances

authors： Kim YJ,Zhang D,Yang DC

更新日期：2015-11-01 00:00:00

abstract：:Grassland is of major importance for agricultural production and provides valuable ecosystem services. Its impact is likely to rise in changing socio-economic and climatic environments. High yielding forage grass species are major components of sustainable grassland production. Understanding the genome structure and f...

journal_title：Biotechnology advances

authors： Kopecký D,Studer B

更新日期：2014-01-01 00:00:00

abstract：:The biotech industry is, nowadays, facing unparalleled challenges due to the enhanced demand for biotechnology-based human therapeutic products, such as monoclonal antibodies (mAbs). This has led companies to improve substantially their upstream processes, with the yield of monoclonals increasing to titers never seen ...

journal_title：Biotechnology advances

authors： Rosa PA,Azevedo AM,Sommerfeld S,Bäcker W,Aires-Barros MR

更新日期：2011-11-01 00:00:00

abstract：:Lactic acid, the most important hydroxycarboxylic acid, is now commercially produced by the fermentation of sugars present in biomass. In addition to its use in the synthesis of biodegradable polymers, lactic acid can be regarded as a feedstock for the green chemistry of the future. Different potentially useful chemic...

journal_title：Biotechnology advances

authors： Gao C,Ma C,Xu P

更新日期：2011-11-01 00:00:00

abstract：:Bacteria produce a large number of different halogenated secondary metabolites. Haloperoxidases are believed to be the enzymes responsible for the halogenation reaction. Two classes of haloperoxidases, heme and nonheme, were isolated from different bacteria and their role in the biosynthesis of halogenated secondary m...

journal_title：Biotechnology advances

authors： Van Pée KH

更新日期：1990-01-01 00:00:00

abstract：:Due to concerns about the unsustainability and predictable shortage of fossil feedstocks, research efforts are currently being made to develop new processes for production of commodities using alternative feedstocks. 3-Hydroxypropionic acid (CAS 503-66-2) was recognised by the US Department of Energy as one of the mos...

journal_title：Biotechnology advances

authors： de Fouchécour F,Sánchez-Castañeda AK,Saulou-Bérion C,Spinnler HÉ

更新日期：2018-01-01 00:00:00

abstract：:Loxoscelism (the term used to define accidents by the bite of brown spiders) has been reported worldwide. Clinical manifestations following brown spider bites are frequently associated with skin degeneration, a massive inflammatory response at the injured region, intravascular hemolysis, platelet aggregation causing t...

journal_title：Biotechnology advances

authors： Senff-Ribeiro A,Henrique da Silva P,Chaim OM,Gremski LH,Paludo KS,Bertoni da Silveira R,Gremski W,Mangili OC,Veiga SS

更新日期：2008-05-01 00:00:00

abstract：:A microbial fuel cell (MFC) is a bioreactor that converts chemical energy in the chemical bonds in organic compounds to electrical energy through catalytic reactions of microorganisms under anaerobic conditions. It has been known for many years that it is possible to generate electricity directly by using bacteria to ...

journal_title：Biotechnology advances

authors： Du Z,Li H,Gu T

更新日期：2007-09-01 00:00:00

abstract：:Plant cell suspension culture (PCSC) has emerged as a viable technology to produce plant specialized metabolites (PSM). While Taxol® and ginsenoside are two examples of successfully commercialized PCSC-derived PSM, widespread utilization of the PCSC platform has yet to be realized primarily due to a lack of understand...

journal_title：Biotechnology advances

authors： Arya SS,Rookes JE,Cahill DM,Lenka SK

更新日期：2020-12-01 00:00:00

abstract：:Pigments (mainly carotenoids) are important nutraceuticals known for their potent anti-oxidant activities and have been used extensively as high end health supplements. Microalgae are the most promising sources of natural carotenoids and are devoid of the toxic effects associated with synthetic derivatives. Compared t...

journal_title：Biotechnology advances

authors： Hu J,Nagarajan D,Zhang Q,Chang JS,Lee DJ

更新日期：2018-01-01 00:00:00

abstract：:Developments in plant genetic engineering technology will shortly permit the commercial introduction of transgenic crop varieties resistant to a number of non-selective herbicides. High levels of tolerance have been achieved both by overexpression of a target protein and by modification of that target to an insensitiv...

journal_title：Biotechnology advances

authors： Quinn JP

更新日期：1990-01-01 00:00:00

abstract：:Osteochondral defect management and repair remain a significant challenge in orthopedic surgery. Osteochondral defects contain damage to both the articular cartilage as well as the underlying subchondral bone. In order to repair an osteochondral defect the needs of the bone, cartilage and the bone-cartilage interface ...

journal_title：Biotechnology advances

authors： Nukavarapu SP,Dorcemus DL

更新日期：2013-09-01 00:00:00

abstract：:The control of hepatitis B virus (HBV) infection is a challenging task, specifically in developing countries there is limited access to diagnostics and antiviral treatment mainly due to high costs and insufficient healthcare infrastructure. Although the current diagnostic technologies can reliably detect HBV, they are...

journal_title：Biotechnology advances

authors： Yildiz UH,Inci F,Wang S,Toy M,Tekin HC,Javaid A,Lau DT,Demirci U

更新日期：2015-01-01 00:00:00

abstract：:In recent years, the use of surface-display vectors for displaying polypeptides on the surface of bacteriophage and bacteria, combined with in vitro selection technologies, has transformed the way in which we generate and manipulate ligands, such as enzymes, antibodies and peptides. Phage display is based on expressin...

journal_title：Biotechnology advances

authors： Benhar I

更新日期：2001-02-01 00:00:00

abstract：:One of the major bottlenecks in automation and process control of industrial bioprocesses is the lack of suitable sensing devices to accurately measure the concentrations of biomolecules. The measurement of ions (e.g., H(+), NH(4)(+)) and gases (e.g., O(2), CO(2), NH(3)) using standard ion-selective and gas sensing el...

journal_title：Biotechnology advances

authors： Graham A,Moo-Young M

更新日期：1985-01-01 00:00:00