Abstract：
:One of the major bottlenecks in automation and process control of industrial bioprocesses is the lack of suitable sensing devices to accurately measure the concentrations of biomolecules. The measurement of ions (e.g., H(+), NH(4)(+)) and gases (e.g., O(2), CO(2), NH(3)) using standard ion-selective and gas sensing electrodes respectively, is well established. Chemical analysis of biomolecules off-line is generally unreliable, labour intensive and may lead to contamination of the biological systems. Problems of maintaining sterile conditions are especially important when dealing with slow growing mammalian or plant cells in culture. Active research in the development of biosensors for monitoring fermentation processes, food production and pollution control, and for medical and veterinary applications is currently underway. This paper reviews recent approaches toward the development of biosensors which involve a biochemical interaction to measure the concentrations of biomolecules, primarily for the on-line monitoring and control of fermentation processes.
journal_name
Biotechnol Advjournal_title
Biotechnology advancesauthors
Graham A,Moo-Young Mdoi
10.1016/0734-9750(85)90292-7subject
Has Abstractpub_date
1985-01-01 00:00:00pages
209-18issue
2eissn
0734-9750issn
1873-1899pii
0734975085902927journal_volume
3pub_type
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journal_title：Biotechnology advances
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journal_title：Biotechnology advances
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journal_title：Biotechnology advances
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pub_type： 杂志文章
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更新日期：2011-05-01 00:00:00
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更新日期：2020-12-01 00:00:00
