Abstract：
:Competitive sustainable production in industry demands new and better biocatalysts, optimized bioprocesses and cost-effective product recovery. Our review sheds light on the progress made for the individual steps towards these goals, starting with the discovery of new enzymes and their corresponding genes. The enzymes are subsequently engineered to improve their performance, combined in reaction cascades to expand the reaction scope and integrated in whole cells to provide an optimal environment for the bioconversion. Strain engineering using synthetic biology methods tunes the host for production, reaction design optimizes the reaction conditions and downstream processing ensures the efficient recovery of commercially viable products. Selected examples illustrate how modified enzymes can revolutionize future-oriented applications ranging from the bioproduction of bulk-, specialty- and fine chemicals, active pharmaceutical ingredients and carbohydrates, over the conversion of the greenhouse-gas CO2 into valuable products and biocontrol in agriculture, to recycling of synthetic polymers and recovery of precious metals.
journal_name
Biotechnol Advjournal_title
Biotechnology advancesauthors
Wiltschi B,Cernava T,Dennig A,Galindo Casas M,Geier M,Gruber S,Haberbauer M,Heidinger P,Herrero Acero E,Kratzer R,Luley-Goedl C,Müller CA,Pitzer J,Ribitsch D,Sauer M,Schmölzer K,Schnitzhofer W,Sensen CW,Soh J,Steinedoi
10.1016/j.biotechadv.2020.107520subject
Has Abstractpub_date
2020-01-01 00:00:00pages
107520eissn
0734-9750issn
1873-1899pii
S0734-9750(20)30017-3journal_volume
40pub_type
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