Abstract:
:Lactic acid, the most important hydroxycarboxylic acid, is now commercially produced by the fermentation of sugars present in biomass. In addition to its use in the synthesis of biodegradable polymers, lactic acid can be regarded as a feedstock for the green chemistry of the future. Different potentially useful chemicals such as pyruvic acid, acrylic acid, 1,2-propanediol, and lactate ester can be produced from lactic acid via chemical and biotechnological routes. Here, we reviewed the current status of the production of potentially valuable chemicals from lactic acid via biotechnological routes. Although some of the reactions described in this review article are still not applicable at current stage, due to their "greener" properties, biotechnological processes for the production of lactic acid derivatives might replace the chemical routes in the future.
journal_name
Biotechnol Advjournal_title
Biotechnology advancesauthors
Gao C,Ma C,Xu Pdoi
10.1016/j.biotechadv.2011.07.022subject
Has Abstractpub_date
2011-11-01 00:00:00pages
930-9issue
6eissn
0734-9750issn
1873-1899pii
S0734-9750(11)00132-7journal_volume
29pub_type
杂志文章,评审abstract::Biopharmaceuticals present the fastest growing segment in the pharmaceutical industry, with an ever widening scope of applications. Whole plants as well as contained plant cell culture systems are being explored for their potential as cheap, safe, and scalable production hosts. The first plant-derived biopharmaceutica...
journal_title:Biotechnology advances
pub_type: 杂志文章,评审
doi:10.1016/j.biotechadv.2009.07.002
更新日期:2009-11-01 00:00:00
abstract::Next generation sequencing is in the process of evolving from a technology used for research purposes to one which is applied in clinical diagnostics. Recently introduced high throughput and benchtop instruments offer fully automated sequencing runs at a lower cost per base and faster assay times. In turn, the complex...
journal_title:Biotechnology advances
pub_type: 杂志文章,评审
doi:10.1016/j.biotechadv.2020.107537
更新日期:2020-01-01 00:00:00
abstract::Complete profiling would substantially facilitate the fundamental understanding of tumor angiogenesis and of possible anti-angiogenesis cancer treatments. We developed an integrated synchrotron-based methodology with excellent performances: detection of very small vessels by high spatial resolution (~1 μm) and nanopar...
journal_title:Biotechnology advances
pub_type: 杂志文章
doi:10.1016/j.biotechadv.2011.12.001
更新日期:2013-05-01 00:00:00
abstract::Food additives and colorants are extensively used in the food industry to improve food quality and safety during processing, storage and packing. Sourcing of these molecules is predominately through three means: extraction from natural sources, chemical synthesis, and bio-production, with the first two being the most ...
journal_title:Biotechnology advances
pub_type: 杂志文章,评审
doi:10.1016/j.biotechadv.2020.107694
更新日期:2021-01-01 00:00:00
abstract::Fungi are notoriously prolific producers of secondary metabolites including nonribosomal peptides (NRPs). The structural complexity of NRPs grants them interesting activities such as antibiotic, anti-cancer, and anti-inflammatory properties. The discovery of these compounds with attractive activities can be achieved b...
journal_title:Biotechnology advances
pub_type: 杂志文章,评审
doi:10.1016/j.biotechadv.2019.107449
更新日期:2019-12-01 00:00:00
abstract::Basic and applied research on microbial cellulases, hemicellulases and pectinases has not only generated significant scientific knowledge but has also revealed their enormous potential in biotechnology. At present, cellulases and related enzymes are used in food, brewery and wine, animal feed, textile and laundry, pul...
journal_title:Biotechnology advances
pub_type: 杂志文章
doi:10.1016/s0734-9750(00)00041-0
更新日期:2000-08-01 00:00:00
abstract::The impact of additive manufacturing in our lives has been increasing constantly. One of the frontiers in this change is the medical devices. 3D printing technologies not only enable the personalization of implantable devices with respect to patient-specific anatomy, pathology and biomechanical properties but they als...
journal_title:Biotechnology advances
pub_type: 杂志文章,评审
doi:10.1016/j.biotechadv.2018.02.004
更新日期:2018-01-01 00:00:00
abstract::The present review provides up-to-date information on the occurrence and methodologies used for producing and purifying endo-β-mannanases and a comprehensive comparison of their biochemical properties. The amalgamation of biochemical, molecular and structural biology approaches which have been used for understanding e...
journal_title:Biotechnology advances
pub_type: 杂志文章,评审
doi:10.1016/j.biotechadv.2016.11.001
更新日期:2017-01-01 00:00:00
abstract::New developments in magnetic labelling techniques for cells and microspheres have extended the useful range of magnetic separation, particularly high gradient magnetic separation, into biotechnical areas. The basic magnetic principles involved are reviewed and representative samples of labelling techniques and results...
journal_title:Biotechnology advances
pub_type: 杂志文章
doi:10.1016/0734-9750(84)90241-6
更新日期:1984-01-01 00:00:00
abstract::DNA vaccination has been widely explored to develop new, alternative and efficient vaccines for cancer immunotherapy. DNA vaccines offer several benefits such as specific targeting, use of multiple genes to enhance immunity and reduced risk compared to conventional vaccines. Rapid developments in molecular biology and...
journal_title:Biotechnology advances
pub_type: 杂志文章,评审
doi:10.1016/j.biotechadv.2011.06.020
更新日期:2012-01-01 00:00:00
abstract::Genetically engineered stem cells aid in dissecting basic cell function and are valuable tools for drug discovery, in vivo cell tracking, and gene therapy. Gene transfer into pluripotent stem cells has been a challenge due to their intrinsic feature of growing in clusters and hence not amenable to common gene delivery...
journal_title:Biotechnology advances
pub_type: 杂志文章,评审
doi:10.1016/j.biotechadv.2013.07.003
更新日期:2013-11-15 00:00:00
abstract::Packed bed cultivation systems have potential for widespread application in solid-state cultivation (SSC), but they are poorly characterized. The effects of particle size and substrate loading on the growth of Rhizopus oligosporus on sago-beads in packed bed bioreactors were investigated. Pressure drop and protein wer...
journal_title:Biotechnology advances
pub_type: 杂志文章
doi:10.1016/0734-9750(93)90029-m
更新日期:1993-01-01 00:00:00
abstract::The marine ecosystem is still an untapped reservoir of biologically active compounds, which have considerable potential to supply food ingredients towards development of new functional foods. With the goal of increasing the availability and chemical diversity of functional marine ingredients, much research has been de...
journal_title:Biotechnology advances
pub_type: 杂志文章,评审
doi:10.1016/j.biotechadv.2012.03.006
更新日期:2012-11-01 00:00:00
abstract::A major feature of twenty-first century medical research is the development of therapeutic strategies that use 'biologics' (large molecules, usually engineered proteins) and living cells instead of, or as well as, the small molecules that were the basis of pharmacology in earlier eras. The high power of these techniqu...
journal_title:Biotechnology advances
pub_type: 杂志文章,评审
doi:10.1016/j.biotechadv.2019.107439
更新日期:2019-12-01 00:00:00
abstract::This review elaborates on the recent development of microbial sterol biotransformation systems. Particular emphasis is laid on the new enzymatic approach investigating the cleavage of sterol side chain. New developments in the area of immobilized cell system and use of organic media along with recent reviews on side c...
journal_title:Biotechnology advances
pub_type: 杂志文章
doi:10.1016/0734-9750(92)91351-e
更新日期:1992-01-01 00:00:00
abstract::Although almost every U.S. pulp mill has a biological wastewater treatment system, these systems based on bacteria, are largely ineffective in the removal of color. For this reason, we have attempted to utilize Phanerochaete chrysosporium, a fungus known to degrade lignin, as the primary organism in a novel waste trea...
journal_title:Biotechnology advances
pub_type: 杂志文章
doi:10.1016/0734-9750(84)90010-7
更新日期:1984-01-01 00:00:00
abstract::Actinomycetes are one of the most valuable sources of natural products with industrial and medicinal importance. After more than half a century of exploitation, it has become increasingly challenging to find novel natural products with useful properties as the same known compounds are often repeatedly re-discovered wh...
journal_title:Biotechnology advances
pub_type: 杂志文章,评审
doi:10.1016/j.biotechadv.2019.03.005
更新日期:2019-11-01 00:00:00
abstract::During a tempe fermentation the concentrations of linoleic, and alpha-linolenic acids (ALA) decreased while the concentration of oleic acid increased. During fatty acid synthesis Rhizopus sp. produced only gamma-linolenic acid (GLA) instead of ALA. The amount of GLA in tempe were influenced by varying external paramet...
journal_title:Biotechnology advances
pub_type: 杂志文章
doi:10.1016/0734-9750(93)90016-g
更新日期:1993-01-01 00:00:00
abstract::Traditional technologies are required to meet specific, quantitative standards of safety and performance. In tissue engineering, similar standards will have to be developed to enable routine clinical use and customized tissue fabrication. In this essay, we discuss a framework of concepts leading towards general design...
journal_title:Biotechnology advances
pub_type: 杂志文章,评审
doi:10.1016/j.biotechadv.2012.12.005
更新日期:2013-09-01 00:00:00
abstract::Integrins are cell adhesion receptors predominantly important during normal and tumor angiogenesis. A sequence present on several extracellular matrix proteins composed of Arg-Gly-Asp (RGD) has attracted attention due to its role in cell adhesion mediated by integrins. The development of ligands that can bind to integ...
journal_title:Biotechnology advances
pub_type: 杂志文章,评审
doi:10.1016/j.biotechadv.2017.11.004
更新日期:2018-01-01 00:00:00
abstract::Biological processes are considered to be the most cost-effective technology for the off-gas treatment of volatile organic compounds (VOC) at low concentrations. Two-phase partitioning bioreactors (TPPBs) emerged in the early 1990s as innovative multiphase systems capable of overcoming some of the key limitations of t...
journal_title:Biotechnology advances
pub_type: 杂志文章,评审
doi:10.1016/j.biotechadv.2012.08.009
更新日期:2012-11-01 00:00:00
abstract::Silver was widely used in medicine to treat bacterial infections in the 19th and early 20th century, up until the discovery and development of the first modern antibiotics in the 1940s, which were markedly more effective. Since then, every new antibiotic introduced to the clinic has led to an associated development of...
journal_title:Biotechnology advances
pub_type: 杂志文章,评审
doi:10.1016/j.biotechadv.2018.05.004
更新日期:2018-01-01 00:00:00
abstract::2-Phenylethanol (2-PE) is an important aromatic alcohol with a rose-like fragrance. It has been widely applied in the cosmetic, perfume, and food industries and is mainly produced by chemical synthesis. An alternative method for the production of natural flavors and fragrances is the microbial transformation process, ...
journal_title:Biotechnology advances
pub_type: 杂志文章,评审
doi:10.1016/j.biotechadv.2011.05.001
更新日期:2011-11-01 00:00:00
abstract::Biotechnological processes based on immobilized viable cells have developed rapidly over the last 30 years. For a long time, basic studies of the physiological behaviour of immobilized cells (IC) have remained in the shadow of the applications. Natural IC structures, i.e. biofilms, are being increasingly investigated ...
journal_title:Biotechnology advances
pub_type: 杂志文章,评审
doi:10.1016/j.biotechadv.2004.06.003
更新日期:2004-11-01 00:00:00
abstract::Fatty acid drug discovery (FADD) is defined as the identification of novel, specialized bioactive mediators that are derived from fatty acids and have precise pharmacological/therapeutic potential. A number of reports indicate that dietary intake of omega-3 fatty acids and limited intake of omega-6 promotes overall he...
journal_title:Biotechnology advances
pub_type: 杂志文章,评审
doi:10.1016/j.biotechadv.2018.02.014
更新日期:2018-01-01 00:00:00
abstract::In order to decrease carbon emissions and negative environmental impacts of various pollutants, biofuel/biochemical production should be promoted for replacing fossil-based industrial processes. Utilization of abundant lignocellulosic biomass as a feedstock has recently become an attractive option. In this review, we ...
journal_title:Biotechnology advances
pub_type: 杂志文章,评审
doi:10.1016/j.biotechadv.2015.06.002
更新日期:2015-11-15 00:00:00
abstract::In recent years, the use of surface-display vectors for displaying polypeptides on the surface of bacteriophage and bacteria, combined with in vitro selection technologies, has transformed the way in which we generate and manipulate ligands, such as enzymes, antibodies and peptides. Phage display is based on expressin...
journal_title:Biotechnology advances
pub_type: 杂志文章
doi:10.1016/s0734-9750(00)00054-9
更新日期:2001-02-01 00:00:00
abstract::β-Galactosidases, an important class of glycosidases, naturally catalyze the hydrolysis of β-galactosidic bonds in oligosaccharides and polysaccharides. Traditionally, these enzymes have been used to degrade lactose in dairy products, which are beneficial for lactose-intolerant people. Attractively, β-galactosidases e...
journal_title:Biotechnology advances
pub_type: 杂志文章,评审
doi:10.1016/j.biotechadv.2019.107465
更新日期:2020-01-01 00:00:00
abstract::Developments in plant genetic engineering technology will shortly permit the commercial introduction of transgenic crop varieties resistant to a number of non-selective herbicides. High levels of tolerance have been achieved both by overexpression of a target protein and by modification of that target to an insensitiv...
journal_title:Biotechnology advances
pub_type: 杂志文章
doi:10.1016/0734-9750(90)91068-r
更新日期:1990-01-01 00:00:00
abstract::The population of sub-Saharan Africa is at risk from multiple, poverty-related endemic diseases. HIV and malaria are the most prevalent, but they disproportionately affect different groups of people, i.e. HIV predominantly affects sexually-active adults whereas malaria has a greater impact on children and pregnant wom...
journal_title:Biotechnology advances
pub_type: 杂志文章,评审
doi:10.1016/j.biotechadv.2014.02.004
更新日期:2014-05-01 00:00:00