Abstract：
:Over the past decade, L-homophenylalanine is extensively used in the pharmaceutical industry as a precursor for production of angiotensin-converting enzyme (ACE) inhibitor, which possesses significant clinical application in the management of hypertension and congestive heart failure (CHF). A number of chemical methods have been reported thus far for the synthesis of L-homophenylalanine. However, chemical methods generally suffer from process complexity, high cost, and environmental pollution. On the other hand, enantiomerically pure L-homophenylalanine can be obtained elegantly and efficiently by employing biocatalytic methods, where it appears to be the most attractive process in terms of potential industrial applications, green chemistry and sustainability. Herein we review the biocatalytic synthesis of vital L-homophenylalanine as potentially useful intermediate in the production of pharmaceutical drugs in environmentally friendly conditions, using membrane bioreactor for sustainable biotransformation process. One envisages the future prospects of developing an integrated membrane bioreactor system with improved performance for L-homophenylalanine production.
journal_name
Biotechnol Advjournal_title
Biotechnology advancesauthors
Ahmad AL,Oh PC,Abd Shukor SRdoi
10.1016/j.biotechadv.2009.01.003subject
Has Abstractpub_date
2009-05-01 00:00:00pages
286-96issue
3eissn
0734-9750issn
1873-1899pii
S0734-9750(09)00017-2journal_volume
27pub_type
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