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A review on disease transmission studies in relationship to production of embryos by in vitro fertilization and to related new reproductive technologies.

Abstract：

:This paper addresses the circumstances of germplasm contamination and updates on transmission of pathogenic agents by embryos produced in vitro and by associated techniques. It has been shown that some pathogenic agents might have been associated with the follicular oocytes and oviductal cells, collected for in vitro fertilization (IVF), resulting in infected embryos. Experimental introduction of pathogenic agent with oocytes or infected semen into the IVF system allows, in most cases, for the fertilization of eggs and for the production of some transferable quality embryos. Rendering of oocytes and embryos free of infectious pathogens, using the standard sequential washing or enzymatic treatment, is inconsistent and more difficult in the presently used in vitro fertilization system as compared to in vivo produced embryos.

journal_name

Biotechnol Adv

journal_title

Biotechnology advances

authors

Bielanski A

doi

10.1016/s0734-9750(97)00041-4

subject

Has Abstract

pub_date

1997-01-01 00:00:00

pages

633-56

issue

3-4

eissn

0734-9750

issn

1873-1899

pii

S0734975097000414

journal_volume

15

pub_type

杂志文章

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