Common problems associated with the microbial productions of aromatic compounds and corresponding metabolic engineering strategies.

abstract：:Liquid formulation of therapeutic proteins is a maturing technology. Demand for products that are easy to use in the clinic or that are amenable to self-administration make a ready to use liquid formulation desirable. Most modern liquid formulations have a simple composition; comprising a buffer, a tonicity modifier, ...

journal_title：Biotechnology advances

authors： Falconer RJ

更新日期：2019-11-15 00:00:00

abstract：:Biological processes are considered to be the most cost-effective technology for the off-gas treatment of volatile organic compounds (VOC) at low concentrations. Two-phase partitioning bioreactors (TPPBs) emerged in the early 1990s as innovative multiphase systems capable of overcoming some of the key limitations of t...

journal_title：Biotechnology advances

authors： Muñoz R,Daugulis AJ,Hernández M,Quijano G

更新日期：2012-11-01 00:00:00

abstract：:Despite their widespread use in patients with acute myocardial infarction, all currently available thrombolytic agents suffer from a number of significant limitations, including resistance to reperfusion, the occurrence of acute coronary reocclusion and bleeding complications. Furthermore, the therapeutic use of plasm...

journal_title：Biotechnology advances

authors： Lijnen HR,Collen D

更新日期：1993-01-01 00:00:00

abstract：:Collagens are a family of at least 30 protein types organized as networks. They constitute the main support material of cells under the form of extracellular matrix as well as for membranes in vessels, organs, and tissue compartments. Collagen network abnormalities are at the origin of many diseases, including myopath...

journal_title：Biotechnology advances

authors： Noreen R,Moenner M,Hwu Y,Petibois C

更新日期：2012-11-01 00:00:00

abstract：:It has recently been discovered that a number of synthetic chemicals and naturally occurring compounds released into the environment can influence endocrine activity. These endocrine-disrupting compounds (EDCs) are highly varied in structure, provenance, and mode of action (MOA). Many EDCs are anthropogenic, products ...

journal_title：Biotechnology advances

authors： Francois E,Wang DY,Fulthorpe R,Liss SN,Edwards EA

更新日期：2003-12-01 00:00:00

abstract：:Lactoferrin, the main iron-binding protein of milk, has biological activities that are essential for the newborn and are beneficial for adults. Given this beneficial effect, there is broad interest in exogenous sources of lactoferrin in human nutrition. Consequently, several transgenic approaches to produce lactoferri...

journal_title：Biotechnology advances

authors： Conesa C,Calvo M,Sánchez L

更新日期：2010-11-01 00:00:00

abstract：:The non-conventional oleaginous yeast Yarrowia lipolytica shows great industrial promise. It naturally produces certain compounds of interest but can also artificially generate non-native metabolites, thanks to an engineering process made possible by the significant expansion of a dedicated genetic toolbox. In this re...

journal_title：Biotechnology advances

authors： Larroude M,Rossignol T,Nicaud JM,Ledesma-Amaro R

更新日期：2018-12-01 00:00:00

abstract：:Industrial biotechnology is reliant on native pathway engineering or foreign pathway introduction for efficient biosynthesis of target products. Chromosomal integration, with intrinsic genetic stability, is an indispensable step for reliable expression of homologous or heterologous genes and pathways in large-scale an...

journal_title：Biotechnology advances

authors： Li L,Liu X,Wei K,Lu Y,Jiang W

更新日期：2019-01-01 00:00:00

abstract：:Quantitative real-time PCR (qPCR) has been widely used in recent environmental microbial ecology studies as a tool for detecting and quantifying microorganisms of interest, which aids in better understandings of the complexity of wastewater microbial communities. Although qPCR can be used to provide more specific and ...

journal_title：Biotechnology advances

authors： Kim J,Lim J,Lee C

更新日期：2013-12-01 00:00:00

abstract：:Bradyrhizobium elkanii produces rhizobitoxine, an enol-ether amino acid, which has been regarded as a phytotoxin because it causes chlorosis in soybeans. However, recent studies have revealed that rhizobitoxine plays a positive role in establishing symbiosis between B. elkanii and host legumes: rhizobitoxine enhances ...

journal_title：Biotechnology advances

authors： Sugawara M,Okazaki S,Nukui N,Ezura H,Mitsui H,Minamisawa K

更新日期：2006-07-01 00:00:00

abstract：:Mitochondrial DNA (mtDNA) mutations have been involved in disease, aging and cancer and furthermore exploited for evolutionary and forensic investigation. When investigating mtDNA mutations the peculiar aspects of mitochondrial genetics, such as heteroplasmy and threshold effect, require suitable approaches which must...

journal_title：Biotechnology advances

authors： Kurelac I,Lang M,Zuntini R,Calabrese C,Simone D,Vicario S,Santamaria M,Attimonelli M,Romeo G,Gasparre G

更新日期：2012-01-01 00:00:00

abstract：:Due to the over-harvesting and deterioration of wild populations, the ever-growing crustacean market is increasingly reliant on aquaculture, driving the need for better management techniques. Since most cultured crustacean species exhibit sexually dimorphic growth patterns, the culture of monosex populations (either a...

journal_title：Biotechnology advances

authors： Ventura T,Sagi A

更新日期：2012-11-01 00:00:00

abstract：:2-Phenylethanol (2-PE) is an important aromatic alcohol with a rose-like fragrance. It has been widely applied in the cosmetic, perfume, and food industries and is mainly produced by chemical synthesis. An alternative method for the production of natural flavors and fragrances is the microbial transformation process, ...

journal_title：Biotechnology advances

authors： Hua D,Xu P

更新日期：2011-11-01 00:00:00

abstract：:Culturing of microalgae as an alternative feedstock for biofuel production has received a lot of attention in recent years due to their fast growth rate and ability to accumulate high quantity of lipid and carbohydrate inside their cells for biodiesel and bioethanol production, respectively. In addition, this superior...

journal_title：Biotechnology advances

authors： Lam MK,Lee KT

更新日期：2012-05-01 00:00:00

abstract：:Medicinal plants have historically proven their value as a source of molecules with therapeutic potential, and nowadays still represent an important pool for the identification of novel drug leads. In the past decades, pharmaceutical industry focused mainly on libraries of synthetic compounds as drug discovery source....

journal_title：Biotechnology advances

authors： Atanasov AG,Waltenberger B,Pferschy-Wenzig EM,Linder T,Wawrosch C,Uhrin P,Temml V,Wang L,Schwaiger S,Heiss EH,Rollinger JM,Schuster D,Breuss JM,Bochkov V,Mihovilovic MD,Kopp B,Bauer R,Dirsch VM,Stuppner H

更新日期：2015-12-01 00:00:00

abstract：:β-Galactosidases, an important class of glycosidases, naturally catalyze the hydrolysis of β-galactosidic bonds in oligosaccharides and polysaccharides. Traditionally, these enzymes have been used to degrade lactose in dairy products, which are beneficial for lactose-intolerant people. Attractively, β-galactosidases e...

journal_title：Biotechnology advances

authors： Lu L,Guo L,Wang K,Liu Y,Xiao M

更新日期：2020-01-01 00:00:00

abstract：:The ubiquitous presence of allergens in the human food supply coupled with increased awareness of food allergies warrants undertaking appropriate preventive measures to protect sensitive consumers from unwanted exposure to offending food allergens. Attempts to reduce or eliminate food allergenicity through food proces...

journal_title：Biotechnology advances

authors： Sathe SK,Teuber SS,Roux KH

更新日期：2005-09-01 00:00:00

abstract：:DNA vaccination has been widely explored to develop new, alternative and efficient vaccines for cancer immunotherapy. DNA vaccines offer several benefits such as specific targeting, use of multiple genes to enhance immunity and reduced risk compared to conventional vaccines. Rapid developments in molecular biology and...

journal_title：Biotechnology advances

authors： Iurescia S,Fioretti D,Fazio VM,Rinaldi M

更新日期：2012-01-01 00:00:00

abstract：:Interest in biobutanol, a sustainable vehicle fuel, is increasing due to rising oil prices and concerns of surrounding climate change and the energy crisis. However, the costs of biobutanol with conventional ABE fermentation by Clostridium are higher than the cost of butanol from today's petrochemical processes. Two m...

journal_title：Biotechnology advances

authors： Huang H,Liu H,Gan YR

更新日期：2010-09-01 00:00:00

abstract：:Biotechnology techniques involving plant tissue culture and recombinant DNA technologies are powerful tools that can complement conventional breeding and expedite Capsicum improvement. The rate of progress in Capsicum is relatively slower than other members of Solanaceae because of its high genotypic dependence and re...

journal_title：Biotechnology advances

authors： Kothari SL,Joshi A,Kachhwaha S,Ochoa-Alejo N

更新日期：2010-01-01 00:00:00

abstract：:NADPH oxidase (NOX) is a key player in the network of reactive oxygen species (ROS) producing enzymes. It catalyzes the production of superoxide (O2(-)), that in turn regulates a wide range of biological functions in a broad range of organisms. Plant Noxes are known as respiratory burst oxidase homologs (Rbohs) and ar...

journal_title：Biotechnology advances

authors： Kaur G,Sharma A,Guruprasad K,Pati PK

更新日期：2014-05-01 00:00:00

abstract：:The world population now is 6.7 billion and is predicted to reach 9 billion by 2050. Such a rapid growing population has tremendously increased the challenge for food security. Obviously, it is impossible for traditional agriculture to ensure the food security, while plant biotechnology offers considerable potential t...

journal_title：Biotechnology advances

authors： Wang B,Zhang Z,Yin Z,Feng C,Wang Q

更新日期：2012-05-01 00:00:00

abstract：:Microalgae are regarded as a potential biomass source for biofuel purposes. With regard to bioethanol production, microalgae seem to overcome traditional substrate drawbacks. Enzymatic activities are responsible for carbon allocation and hence for carbohydrate profiles. Enzyme activities may be manipulated by metaboli...

journal_title：Biotechnology advances

authors： González-Fernández C,Ballesteros M

更新日期：2012-11-01 00:00:00

abstract：:The aldopentose D-xylose is one of the most abundant sugars in plant biomass and its efficient microbial utilization is of fundamental importance in the overall bioconversion of lignocellulosic materials into liquid fuels and chemicals. The discovery of pentose-fermenting yeasts in the early 1980's led to world wide i...

journal_title：Biotechnology advances

authors： Webb SR,Lee H

更新日期：1990-01-01 00:00:00

abstract：:Grassland is of major importance for agricultural production and provides valuable ecosystem services. Its impact is likely to rise in changing socio-economic and climatic environments. High yielding forage grass species are major components of sustainable grassland production. Understanding the genome structure and f...

journal_title：Biotechnology advances

authors： Kopecký D,Studer B

更新日期：2014-01-01 00:00:00

abstract：:The use of somatic embryos as artificial seeds for large scale clonal propagation of plants is close to becoming a reality. The quality of the artificial seed depends on the temporal, quantitative and qualitative supply of growth regulator and nutrients along with an optimal physical environment. Desiccation of somati...

journal_title：Biotechnology advances

authors： Senaratna T

更新日期：1992-01-01 00:00:00

abstract：:There is considerable interest in recent years in the bioconversion of forestry and agricultural residues into ethanol and value-added chemicals. High ethanol yields from lignocellulosic residues are dependent on efficient use of all the available sugars including glucose and xylose. The well-known fermentative yeast ...

journal_title：Biotechnology advances

authors： Chu BC,Lee H

更新日期：2007-09-01 00:00:00

abstract：:The biotech industry is, nowadays, facing unparalleled challenges due to the enhanced demand for biotechnology-based human therapeutic products, such as monoclonal antibodies (mAbs). This has led companies to improve substantially their upstream processes, with the yield of monoclonals increasing to titers never seen ...

journal_title：Biotechnology advances

authors： Rosa PA,Azevedo AM,Sommerfeld S,Bäcker W,Aires-Barros MR

更新日期：2011-11-01 00:00:00

abstract：:Tissue maceration was generally elucidated by the action of endo-polygalacturonase and endo-pectate or -pectin lyase (endo-PAL or -PNL). In a process of screening of Erwinia and Pseudomonas strains for enzymatic pulping of pectocellulosic bast fibers, it was found that their PAL productivity was not completely related...

journal_title：Biotechnology advances

authors： Kobayashi Y,Komae K,Tanabe H,Matsuo R

更新日期：1988-01-01 00:00:00

abstract：:Although almost every U.S. pulp mill has a biological wastewater treatment system, these systems based on bacteria, are largely ineffective in the removal of color. For this reason, we have attempted to utilize Phanerochaete chrysosporium, a fungus known to degrade lignin, as the primary organism in a novel waste trea...

journal_title：Biotechnology advances

authors： Joyce TW,Chang H,Campbell AG Jr,Gerrard ED,Kirk TK

更新日期：1984-01-01 00:00:00