当前位置： SCI文献检索 > BIOTECHNOLOGY ADVANCES期刊下所有文献 > DNA microarrays for detecting endocrine-disrupting compounds.

DNA microarrays for detecting endocrine-disrupting compounds.

Abstract：

:It has recently been discovered that a number of synthetic chemicals and naturally occurring compounds released into the environment can influence endocrine activity. These endocrine-disrupting compounds (EDCs) are highly varied in structure, provenance, and mode of action (MOA). Many EDCs are anthropogenic, products of the chemical industry. Others are natural compounds. Although natural hormones exist at low levels in the environment, industrial sites such as pulp and paper mills and municipal sewage treatment plants can gather large amounts of natural EDCs and release them into the environment as part of their daily operations, thus increasing background environmental concentrations. The potential consequences of endocrine disruption are serious; however, comparatively little is known about the phenomenon. There is considerable debate over the true concentrations, sources, identity, and effects of potential EDCs. Investigation of the problem is hampered by the diversity of potential EDCs, which may have synergistic as well as individual effects, and the complexity of the endocrine system itself. Effective and standardized tests to accurately detect the presence of such chemicals in the environment are not available. While many tests have been proposed, they are unsatisfactory because they have only one limited endpoint (e.g., they can detect only one of many potential hormonal responses) and do not provide any mechanistic information. In addition, results from rapid screening tests are difficult to correlate with whole organism response, while larger whole organism bioassays are very costly and time consuming to perform. There is tremendous potential in the application of DNA microarray technology to screen for EDCs. DNA microarrays provide a "snapshot" of transcriptional activity in tissue samples showing which genes were actively expressed within the cells at one point in time. By combining this technology with human cell lines grown in vitro, it should be possible to conduct relatively rapid and straightforward assays to identify EDCs by observing the changes in gene expression patterns in response to exposure.

journal_name

Biotechnol Adv

journal_title

Biotechnology advances

authors

Francois E,Wang DY,Fulthorpe R,Liss SN,Edwards EA

doi

10.1016/j.biotechadv.2003.08.005

subject

Has Abstract

pub_date

2003-12-01 00:00:00

pages

17-26

issue

1-2

eissn

0734-9750

issn

1873-1899

pii

S0734975003001241

journal_volume

22

pub_type

杂志文章,评审

相关文献

BIOTECHNOLOGY ADVANCES文献大全
  • Biochemical pathways and mechanisms nitrogen, amino acid, and carbon metabolism.

    abstract：:For both nitrogen and carbon metabolism there exist specific regulatory mechanisms to enable cells to assimilate a wide variety of nitrogen and carbon sources. Superimposed are regulatory circuits, the so called nitrogen and carbon catabolite regulation, to allow for selective use of "rich" sources first and "poor" so...

    journal_title：Biotechnology advances

    pub_type： 杂志文章

    doi：10.1016/0734-9750(83)90587-6

    authors： Hütter R,Niederberger P

    更新日期：1983-01-01 00:00:00

  • Nonribosomal peptides in fungal cell factories: from genome mining to optimized heterologous production.

    abstract：:Fungi are notoriously prolific producers of secondary metabolites including nonribosomal peptides (NRPs). The structural complexity of NRPs grants them interesting activities such as antibiotic, anti-cancer, and anti-inflammatory properties. The discovery of these compounds with attractive activities can be achieved b...

    journal_title：Biotechnology advances

    pub_type： 杂志文章,评审

    doi：10.1016/j.biotechadv.2019.107449

    authors： Vassaux A,Meunier L,Vandenbol M,Baurain D,Fickers P,Jacques P,Leclère V

    更新日期：2019-12-01 00:00:00

  • An economic assessment of astaxanthin production by large scale cultivation of Haematococcus pluvialis.

    abstract：:Although natural sources have long been exploited for astaxanthin production, it is still uncertain if natural astaxanthin can be produced at lower cost than that of synthetic astaxanthin or not. In order to give a comprehensive cost analysis of astaxanthin production from Haematococcus, a pilot plant with two large s...

    journal_title：Biotechnology advances

    pub_type： 杂志文章,评审

    doi：10.1016/j.biotechadv.2011.04.001

    authors： Li J,Zhu D,Niu J,Shen S,Wang G

    更新日期：2011-11-01 00:00:00

  • Cellular engineering strategies toward sustainable omega-3 long chain polyunsaturated fatty acids production: State of the art and perspectives.

    abstract：:Long-chain polyunsaturated fatty acids (LC-PUFAs) especially ω-3 fatty acids provide significant health benefits for human beings. However, ω-3 LC-PUFAs cannot be synthesized de novo in mammals. Traditionally, ω-3 LC-PUFAs are extracted from marine fish, and their production depends on sea fishing, which has not met e...

    journal_title：Biotechnology advances

    pub_type： 杂志文章,评审

    doi：10.1016/j.biotechadv.2019.107497

    authors： Diao J,Song X,Guo T,Wang F,Chen L,Zhang W

    更新日期：2020-01-01 00:00:00

  • Development of thrombolytic agents.

    abstract：:Despite their widespread use in patients with acute myocardial infarction, all currently available thrombolytic agents suffer from a number of significant limitations, including resistance to reperfusion, the occurrence of acute coronary reocclusion and bleeding complications. Furthermore, the therapeutic use of plasm...

    journal_title：Biotechnology advances

    pub_type： 杂志文章

    doi：10.1016/0734-9750(93)90411-f

    authors： Lijnen HR,Collen D

    更新日期：1993-01-01 00:00:00

  • Design standards for engineered tissues.

    abstract：:Traditional technologies are required to meet specific, quantitative standards of safety and performance. In tissue engineering, similar standards will have to be developed to enable routine clinical use and customized tissue fabrication. In this essay, we discuss a framework of concepts leading towards general design...

    journal_title：Biotechnology advances

    pub_type： 杂志文章,评审

    doi：10.1016/j.biotechadv.2012.12.005

    authors： Nawroth JC,Parker KK

    更新日期：2013-09-01 00:00:00

  • Challenges and solutions for biofiltration of hydrophobic volatile organic compounds.

    abstract：:Volatile organic compounds (VOCs) emitted to the environment highly probably result in ecological and health risks. Many biotechnologies for waste gases containing hydrophobic VOCs have been developed in recent years. However, these biological processes usually exhibit poor removal performances for hydrophobic VOCs du...

    journal_title：Biotechnology advances

    pub_type： 杂志文章,评审

    doi：10.1016/j.biotechadv.2016.06.007

    authors： Cheng Y,He H,Yang C,Zeng G,Li X,Chen H,Yu G

    更新日期：2016-11-01 00:00:00

  • Quantitative real-time PCR approaches for microbial community studies in wastewater treatment systems: applications and considerations.

    abstract：:Quantitative real-time PCR (qPCR) has been widely used in recent environmental microbial ecology studies as a tool for detecting and quantifying microorganisms of interest, which aids in better understandings of the complexity of wastewater microbial communities. Although qPCR can be used to provide more specific and ...

    journal_title：Biotechnology advances

    pub_type： 杂志文章,评审

    doi：10.1016/j.biotechadv.2013.05.010

    authors： Kim J,Lim J,Lee C

    更新日期：2013-12-01 00:00:00

  • Biotechnological applications of cyclodextrins.

    abstract：:Cyclodextrins (CDs) are a family of cyclic oligosaccharides that are composed of alpha-1,4-linked glucopyranose subunits. Cyclodextrins are produced from starch by enzymatic degradation. These macrocyclic carbohydrates with apolar internal cavities can form complexes with and solubilize many normally water-insoluble c...

    journal_title：Biotechnology advances

    pub_type： 杂志文章

    doi：10.1016/s0734-9750(02)00020-4

    authors： Singh M,Sharma R,Banerjee UC

    更新日期：2002-12-01 00:00:00

  • Vero cell upstream bioprocess development for the production of viral vectors and vaccines.

    abstract：:The Vero cell line is considered the most used continuous cell line for the production of viral vectors and vaccines. Historically, it is the first cell line that was approved by the WHO for the production of human vaccines. Comprehensive experimental data on the production of many viruses using the Vero cell line can...

    journal_title：Biotechnology advances

    pub_type： 杂志文章,评审

    doi：10.1016/j.biotechadv.2020.107608

    authors： Kiesslich S,Kamen AA

    更新日期：2020-11-15 00:00:00

  • Common problems associated with the microbial productions of aromatic compounds and corresponding metabolic engineering strategies.

    abstract：:Recent progress in metabolic engineering and synthetic biology has enabled the production of valuable chemicals in microbial cell factories from renewable feedstocks. High value-added aromatic compounds, most of which are traditionally chemically synthesized from petroleum-derived feedstocks, represent a large class o...

    journal_title：Biotechnology advances

    pub_type： 杂志文章,评审

    doi：10.1016/j.biotechadv.2020.107548

    authors： Li M,Liu C,Yang J,Nian R,Xian M,Li F,Zhang H

    更新日期：2020-01-01 00:00:00

  • A continuous biological process to decolorize bleach plant effluents.

    abstract：:Although almost every U.S. pulp mill has a biological wastewater treatment system, these systems based on bacteria, are largely ineffective in the removal of color. For this reason, we have attempted to utilize Phanerochaete chrysosporium, a fungus known to degrade lignin, as the primary organism in a novel waste trea...

    journal_title：Biotechnology advances

    pub_type： 杂志文章

    doi：10.1016/0734-9750(84)90010-7

    authors： Joyce TW,Chang H,Campbell AG Jr,Gerrard ED,Kirk TK

    更新日期：1984-01-01 00:00:00

  • Enzymes to unravel bioproducts architecture.

    abstract：:Enzymes are essential and ubiquitous biocatalysts involved in various metabolic pathways and used in many industrial processes. Here, we reframe enzymes not just as biocatalysts transforming bioproducts but also as sensitive probes for exploring the structure and composition of complex bioproducts, like meat tissue, d...

    journal_title：Biotechnology advances

    pub_type： 杂志文章,评审

    doi：10.1016/j.biotechadv.2020.107546

    authors： Bourlieu C,Astruc T,Barbe S,Berrin JG,Bonnin E,Boutrou R,Hugouvieux V,Le Feunteun S,Paës G

    更新日期：2020-01-01 00:00:00

  • Ecological risk assessment of genetically modified crops based on cellular automata modeling.

    abstract：:The assessment of ecological risk in genetically modified (GM) biological systems is critically important for decision-making and public acceptance. Cellular automata (CA) provide a potential modeling and simulation framework for representing relationships and interspecies interactions both temporally and spatially. I...

    journal_title：Biotechnology advances

    pub_type： 杂志文章

    doi：10.1016/j.biotechadv.2009.05.024

    authors： Yang J,Wang ZR,Yang DL,Yang Q,Yan J,He MF

    更新日期：2009-11-01 00:00:00

  • Library preparation for next generation sequencing: A review of automation strategies.

    abstract：:Next generation sequencing is in the process of evolving from a technology used for research purposes to one which is applied in clinical diagnostics. Recently introduced high throughput and benchtop instruments offer fully automated sequencing runs at a lower cost per base and faster assay times. In turn, the complex...

    journal_title：Biotechnology advances

    pub_type： 杂志文章,评审

    doi：10.1016/j.biotechadv.2020.107537

    authors： Hess JF,Kohl TA,Kotrová M,Rönsch K,Paprotka T,Mohr V,Hutzenlaub T,Brüggemann M,Zengerle R,Niemann S,Paust N

    更新日期：2020-01-01 00:00:00

  • β-Galactosidases: A great tool for synthesizing galactose-containing carbohydrates.

    abstract：:β-Galactosidases, an important class of glycosidases, naturally catalyze the hydrolysis of β-galactosidic bonds in oligosaccharides and polysaccharides. Traditionally, these enzymes have been used to degrade lactose in dairy products, which are beneficial for lactose-intolerant people. Attractively, β-galactosidases e...

    journal_title：Biotechnology advances

    pub_type： 杂志文章,评审

    doi：10.1016/j.biotechadv.2019.107465

    authors： Lu L,Guo L,Wang K,Liu Y,Xiao M

    更新日期：2020-01-01 00:00:00

  • Advances in genetic modification of pluripotent stem cells.

    abstract：:Genetically engineered stem cells aid in dissecting basic cell function and are valuable tools for drug discovery, in vivo cell tracking, and gene therapy. Gene transfer into pluripotent stem cells has been a challenge due to their intrinsic feature of growing in clusters and hence not amenable to common gene delivery...

    journal_title：Biotechnology advances

    pub_type： 杂志文章,评审

    doi：10.1016/j.biotechadv.2013.07.003

    authors： Fontes A,Lakshmipathy U

    更新日期：2013-11-15 00:00:00

  • The production of biopharmaceuticals in plant systems.

    abstract：:Biopharmaceuticals present the fastest growing segment in the pharmaceutical industry, with an ever widening scope of applications. Whole plants as well as contained plant cell culture systems are being explored for their potential as cheap, safe, and scalable production hosts. The first plant-derived biopharmaceutica...

    journal_title：Biotechnology advances

    pub_type： 杂志文章,评审

    doi：10.1016/j.biotechadv.2009.07.002

    authors： Karg SR,Kallio PT

    更新日期：2009-11-01 00:00:00

  • Paradigm shift - Metabolic transformation of docosahexaenoic and eicosapentaenoic acids to bioactives exemplify the promise of fatty acid drug discovery.

    abstract：:Fatty acid drug discovery (FADD) is defined as the identification of novel, specialized bioactive mediators that are derived from fatty acids and have precise pharmacological/therapeutic potential. A number of reports indicate that dietary intake of omega-3 fatty acids and limited intake of omega-6 promotes overall he...

    journal_title：Biotechnology advances

    pub_type： 杂志文章,评审

    doi：10.1016/j.biotechadv.2018.02.014

    authors： Halade GV,Black LM,Verma MK

    更新日期：2018-01-01 00:00:00

  • Frozen beauty: The cryobiotechnology of orchid diversity.

    abstract：:Orchids (Orchidaceae) are one of the most diverse plant groups on the planet with over 25,000 species. For over a century, scientists and horticulturalists have been fascinated by their complex floral morphology, pollinator specificity and multiple ethnobotanical uses, including as food, flavourings, medicines, orname...

    journal_title：Biotechnology advances

    pub_type： 杂志文章,评审

    doi：10.1016/j.biotechadv.2016.01.001

    authors： Popova E,Kim HH,Saxena PK,Engelmann F,Pritchard HW

    更新日期：2016-07-01 00:00:00

  • Exosome biogenesis, bioactivities and functions as new delivery systems of natural compounds.

    abstract：:A rapidly growing body of experimental evidence has begun to shed light on the wide ranging molecular mechanisms which modulate intra- and inter-cellular communications. A substantial quantity of the available knowledge has only been uncovered in recent years, and we are learning that donor cells release nanovesicles,...

    journal_title：Biotechnology advances

    pub_type： 杂志文章,评审

    doi：10.1016/j.biotechadv.2017.12.010

    authors： Farooqi AA,Desai NN,Qureshi MZ,Librelotto DRN,Gasparri ML,Bishayee A,Nabavi SM,Curti V,Daglia M

    更新日期：2018-01-01 00:00:00

  • Biological valorization of low molecular weight lignin.

    abstract：:Lignin is a major component of lignocellulosic biomass and as such, it is processed in enormous amounts in the pulp and paper industry worldwide. In such industry it mainly serves the purpose of a fuel to provide process steam and electricity, and to a minor extent to provide low grade heat for external purposes. Also...

    journal_title：Biotechnology advances

    pub_type： 杂志文章,评审

    doi：10.1016/j.biotechadv.2016.10.001

    authors： Abdelaziz OY,Brink DP,Prothmann J,Ravi K,Sun M,García-Hidalgo J,Sandahl M,Hulteberg CP,Turner C,Lidén G,Gorwa-Grauslund MF

    更新日期：2016-12-01 00:00:00

  • Marine biotechnology advances towards applications in new functional foods.

    abstract：:The marine ecosystem is still an untapped reservoir of biologically active compounds, which have considerable potential to supply food ingredients towards development of new functional foods. With the goal of increasing the availability and chemical diversity of functional marine ingredients, much research has been de...

    journal_title：Biotechnology advances

    pub_type： 杂志文章,评审

    doi：10.1016/j.biotechadv.2012.03.006

    authors： Freitas AC,Rodrigues D,Rocha-Santos TA,Gomes AM,Duarte AC

    更新日期：2012-11-01 00:00:00

  • Implementing CRISPR-Cas technologies in conventional and non-conventional yeasts: Current state and future prospects.

    abstract：:Within five years, the CRISPR-Cas system has emerged as the dominating tool for genome engineering, while also changing the speed and efficiency of metabolic engineering in conventional (Saccharomyces cerevisiae and Schizosaccharomyces pombe) and non-conventional (Yarrowia lipolytica, Pichia pastoris syn. Komagataella...

    journal_title：Biotechnology advances

    pub_type： 杂志文章,评审

    doi：10.1016/j.biotechadv.2018.01.006

    authors： Raschmanová H,Weninger A,Glieder A,Kovar K,Vogl T

    更新日期：2018-01-01 00:00:00

  • Inverse pharmacology: Approaches and tools for introducing druggability into engineered proteins.

    abstract：:A major feature of twenty-first century medical research is the development of therapeutic strategies that use 'biologics' (large molecules, usually engineered proteins) and living cells instead of, or as well as, the small molecules that were the basis of pharmacology in earlier eras. The high power of these techniqu...

    journal_title：Biotechnology advances

    pub_type： 杂志文章,评审

    doi：10.1016/j.biotechadv.2019.107439

    authors： Davies JA,Ireland S,Harding S,Sharman JL,Southan C,Dominguez-Monedero A

    更新日期：2019-12-01 00:00:00

  • Osteochondral tissue engineering: current strategies and challenges.

    abstract：:Osteochondral defect management and repair remain a significant challenge in orthopedic surgery. Osteochondral defects contain damage to both the articular cartilage as well as the underlying subchondral bone. In order to repair an osteochondral defect the needs of the bone, cartilage and the bone-cartilage interface ...

    journal_title：Biotechnology advances

    pub_type： 杂志文章,评审

    doi：10.1016/j.biotechadv.2012.11.004

    authors： Nukavarapu SP,Dorcemus DL

    更新日期：2013-09-01 00:00:00

  • Protein and lysate array technologies in cancer research.

    abstract：:Capturing quantitative proteomic information provides new insights for enhancing the understanding of cancer biology. There have been several protein microarray formats, and each has an advantage depending on what is being detected. However, in contrast to nucleotide printing, the production of protein arrays generall...

    journal_title：Biotechnology advances

    pub_type： 杂志文章,评审

    doi：10.1016/j.biotechadv.2008.04.002

    authors： Spurrier B,Honkanen P,Holway A,Kumamoto K,Terashima M,Takenoshita S,Wakabayashi G,Austin J,Nishizuka S

    更新日期：2008-07-01 00:00:00

  • Tempe fermentation: some aspects of formation of gamma-linolenic acid, proteases and vitamins.

    abstract：:During a tempe fermentation the concentrations of linoleic, and alpha-linolenic acids (ALA) decreased while the concentration of oleic acid increased. During fatty acid synthesis Rhizopus sp. produced only gamma-linolenic acid (GLA) instead of ALA. The amount of GLA in tempe were influenced by varying external paramet...

    journal_title：Biotechnology advances

    pub_type： 杂志文章

    doi：10.1016/0734-9750(93)90016-g

    authors： Bisping B,Hering L,Baumann U,Denter J,Keuth S,Rehm HJ

    更新日期：1993-01-01 00:00:00

  • Microbial biotransformation of bioactive flavonoids.

    abstract：:The bioactive flavonoids are considered as the most important phytochemicals in food, which exert a wide range of biological benefits for human being. Microbial biotransformation strategies for production of flavonoids have attracted considerable interest because they allow yielding novel flavonoids, which do not exis...

    journal_title：Biotechnology advances

    pub_type： 杂志文章,评审

    doi：10.1016/j.biotechadv.2014.10.012

    authors： Cao H,Chen X,Jassbi AR,Xiao J

    更新日期：2015-01-01 00:00:00

  • Enabling personalized implant and controllable biosystem development through 3D printing.

    abstract：:The impact of additive manufacturing in our lives has been increasing constantly. One of the frontiers in this change is the medical devices. 3D printing technologies not only enable the personalization of implantable devices with respect to patient-specific anatomy, pathology and biomechanical properties but they als...

    journal_title：Biotechnology advances

    pub_type： 杂志文章,评审

    doi：10.1016/j.biotechadv.2018.02.004

    authors： Nagarajan N,Dupret-Bories A,Karabulut E,Zorlutuna P,Vrana NE

    更新日期：2018-01-01 00:00:00