Genetic improvement of Saccharomyces cerevisiae for xylose fermentation.

abstract：:Yersinia pestis, the causative agent of bubonic and pneumonic plague, is an extremely virulent bacterium but there are currently no approved vaccines for protection against this organism. Plants represent an economical and safer alternative to fermentation-based expression systems for the production of therapeutic pro...

journal_title：Biotechnology advances

authors： Alvarez ML,Cardineau GA

更新日期：2010-01-01 00:00:00

abstract：:The transition from the vegetative to reproductive stage followed by inflorescence is a critical step in plant life; therefore, studies of the genes that influence flowering time have always been of great interest to scientists. Flowering is a process controlled by many genes interacting mutually in a genetic network,...

journal_title：Biotechnology advances

authors： Milec Z,Valárik M,Bartoš J,Safář J

更新日期：2014-01-01 00:00:00

abstract：:For both nitrogen and carbon metabolism there exist specific regulatory mechanisms to enable cells to assimilate a wide variety of nitrogen and carbon sources. Superimposed are regulatory circuits, the so called nitrogen and carbon catabolite regulation, to allow for selective use of "rich" sources first and "poor" so...

journal_title：Biotechnology advances

authors： Hütter R,Niederberger P

更新日期：1983-01-01 00:00:00

abstract：:There is nowadays no single fully satisfactory method for VOC removal from indoor air due to the difficulties linked to the very low concentration (microg m(-3) range), diversity, and variability at which VOCs are typically found in the indoor environment. Although biological methods have shown a certain potential for...

journal_title：Biotechnology advances

authors： Guieysse B,Hort C,Platel V,Munoz R,Ondarts M,Revah S

更新日期：2008-09-01 00:00:00

abstract：:The filamentous fungus Ashbya gossypii has been safely and successfully used for more than two decades in the commercial production of riboflavin (vitamin B2). Its industrial relevance combined with its high genetic similarity with Saccharomyces cerevisiae together promoted the accumulation of fundamental knowledge th...

journal_title：Biotechnology advances

authors： Aguiar TQ,Silva R,Domingues L

更新日期：2015-12-01 00:00:00

abstract：:Direct interspecies electron transfer (DIET) via electrically conductive pili (e-pili) and c-type cytochrome between acetogens and methanogens has been proposed as an essential pathway for methane production. Supplements of conductive materials have been extensively found to promote methane production in microbial ana...

journal_title：Biotechnology advances

authors： Yin Q,Wu G

更新日期：2019-12-01 00:00:00

abstract：:Traditional technologies are required to meet specific, quantitative standards of safety and performance. In tissue engineering, similar standards will have to be developed to enable routine clinical use and customized tissue fabrication. In this essay, we discuss a framework of concepts leading towards general design...

journal_title：Biotechnology advances

authors： Nawroth JC,Parker KK

更新日期：2013-09-01 00:00:00

abstract：:The aldopentose D-xylose is one of the most abundant sugars in plant biomass and its efficient microbial utilization is of fundamental importance in the overall bioconversion of lignocellulosic materials into liquid fuels and chemicals. The discovery of pentose-fermenting yeasts in the early 1980's led to world wide i...

journal_title：Biotechnology advances

authors： Webb SR,Lee H

更新日期：1990-01-01 00:00:00

abstract：:This paper addresses the circumstances of germplasm contamination and updates on transmission of pathogenic agents by embryos produced in vitro and by associated techniques. It has been shown that some pathogenic agents might have been associated with the follicular oocytes and oviductal cells, collected for in vitro ...

journal_title：Biotechnology advances

authors： Bielanski A

更新日期：1997-01-01 00:00:00

abstract：:Compared with the better-studied canonical amino acids, the distribution, metabolism and functions of natural non-canonical amino acids remain relatively obscure. Natural non-canonical amino acids have been mainly discovered in plants as secondary metabolites that perform diversified physiological functions. Due to th...

journal_title：Biotechnology advances

authors： Zou H,Li L,Zhang T,Shi M,Zhang N,Huang J,Xian M

更新日期：2018-11-15 00:00:00

abstract：:Hydrolysis of the whey protein alpha-lactalbumin with a specific serine protease has been shown to result in regular nanotubes of approximately 20 nm in outer diameter and reaching several mum in length. Tubular assembly depends on the concentration of protein as this determines how far the hydrolysis proceeds. A conc...

journal_title：Biotechnology advances

authors： Ipsen R,Otte J

更新日期：2007-11-01 00:00:00

abstract：:Competitive sustainable production in industry demands new and better biocatalysts, optimized bioprocesses and cost-effective product recovery. Our review sheds light on the progress made for the individual steps towards these goals, starting with the discovery of new enzymes and their corresponding genes. The enzymes...

journal_title：Biotechnology advances

authors： Wiltschi B,Cernava T,Dennig A,Galindo Casas M,Geier M,Gruber S,Haberbauer M,Heidinger P,Herrero Acero E,Kratzer R,Luley-Goedl C,Müller CA,Pitzer J,Ribitsch D,Sauer M,Schmölzer K,Schnitzhofer W,Sensen CW,Soh J,Steine

更新日期：2020-01-01 00:00:00

abstract：:Cryptosporidium parvum is an obligate protozoan parasite responsible for the diarrheal illness cryptosporidiosis in humans and animals. Although C. parvum is particularly pathogenic in immunocompromised hosts, the molecular mechanisms by which C. parvum invades the host epithelial cells are not well understood. Charac...

journal_title：Biotechnology advances

authors： Boulter-Bitzer JI,Lee H,Trevors JT

更新日期：2007-01-01 00:00:00

abstract：:The concept of the Truncated Light-harvesting chlorophyll Antenna (TLA) size, as a tool by which to maximize sunlight utilization and photosynthetic productivity in microalgal mass cultures or high-density plant canopies, is discussed. TLA technology is known to improve sunlight-to-product energy conversion efficienci...

journal_title：Biotechnology advances

authors： Kirst H,Melis A

更新日期：2014-01-01 00:00:00

abstract：:Iron is indispensible for life and essential for such processes as oxygen transport, electron transfer and DNA synthesis. Transferrin (Tf) is a ubiquitous protein with a central role in iron transport and metabolism. There is evidence, however, that Tf has many other biological roles in addition to its primary functio...

journal_title：Biotechnology advances

authors： Brandsma ME,Jevnikar AM,Ma S

更新日期：2011-03-01 00:00:00

abstract：:Citric acid is the principal organic acid found in citrus fruits. To meet increasing demands it is produced from carbohydrate feedstock by fermentation with the fungus Aspergillus niger and the yeasts of Candida spp. Effect of various fermentation conditions and the biochemistry of citric acid formation by A. niger ha...

journal_title：Biotechnology advances

authors： Grewal HS,Kalra KL

更新日期：1995-01-01 00:00:00

abstract：:Vaccines represent a special class of drugs, capable of stimulating immune system responses against pathogens and tumors. Vaccine development is a lengthy process that includes expensive laboratory experiments in order to assess safety and effectiveness. As the efficacy of a vaccine was demonstrated by biological/chem...

journal_title：Biotechnology advances

authors： Pappalardo F,Pennisi M,Castiglione F,Motta S

更新日期：2010-01-01 00:00:00

abstract：:Ribosomally synthesized peptides with antimicrobial properties (antimicrobial peptides-AMPs) are produced by eukaryotes and prokaryotes and represent crucial components of their defense systems against microorganisms. Although they differ in structure, they are nearly all cationic and very often amphiphilic, which ref...

journal_title：Biotechnology advances

authors： Papagianni M

更新日期：2003-09-01 00:00:00

abstract：:Pichia pastoris, a methylotrophic yeast, is an established system for the production of heterologous proteins, particularly biopharmaceuticals and industrial enzymes. To maximise and optimise the production of recombinant products, recent molecular research has focused on numerous issues including the design of expres...

journal_title：Biotechnology advances

authors： Looser V,Bruhlmann B,Bumbak F,Stenger C,Costa M,Camattari A,Fotiadis D,Kovar K

更新日期：2015-11-01 00:00:00

abstract：:This review discusses peptide-based vaccines in breast cancer, immune responses and clinical outcomes, which include studies on animal models and phase I, phase I/II, phase II and phase III clinical trials. Peptide-based vaccines are powerful neoadjuvant immunotherapies that can directly target proteins expressed in t...

journal_title：Biotechnology advances

authors： Peres Lde P,da Luz FA,Pultz Bdos A,Brígido PC,de Araújo RA,Goulart LR,Silva MJ

更新日期：2015-12-01 00:00:00

abstract：:Monoclonal antibodies (MCAs) have found widespread applications in livestock production. Although the generation of murine MCAs is at present a routine, the production of homologous MCAs, especially important for in vivo applications, is still hampered by the lack of efficient homologous fusion partners for immortaliz...

journal_title：Biotechnology advances

authors： Van Der Lende T

更新日期：1994-01-01 00:00:00

abstract：:This work reviews applications of high added value molecules produced from microalgae. Older forms of valorization - health food and quality feed, polyunsaturated fatty acids, pigments, carbohydrates - are currently penetrating their markets. They are driven by desirable properties: texturer and dye for food industry,...

journal_title：Biotechnology advances

authors： Levasseur W,Perré P,Pozzobon V

更新日期：2020-01-01 00:00:00

abstract：:In the biological milieu of a cell, soluble crowding molecules and rigid confined environments strongly influence whether the protein is properly folded, intrinsically disordered proteins assemble into distinct phases, or a denatured or aggregated protein species is favored. Such crowding and confinement factors act t...

journal_title：Biotechnology advances

authors： Simpson LW,Good TA,Leach JB

更新日期：2020-01-01 00:00:00

abstract：:Biomass, a renewable, sustainable and carbon dioxide neutral resource, has received widespread attention in the energy market as an alternative to fossil fuels. Thermal-chemical conversion of biomass to produce biofuels is a promising technology with many commercial applications. This paper reviewed the state-of-the-a...

journal_title：Biotechnology advances

authors： Ma L,Wang T,Liu Q,Zhang X,Ma W,Zhang Q

更新日期：2012-07-01 00:00:00

abstract：:The potential for gene therapy to cure a wide range of diseases has lead to high expectations and a great increase in research efforts in this area. At present, viral vectors are the most efficient means of delivering a corrective gene into human cells. While a number of different viral vectors are under development, ...

journal_title：Biotechnology advances

authors： McTaggart S,Al-Rubeai M

更新日期：2002-04-01 00:00:00

abstract：:Volatile organic compounds (VOCs) emitted to the environment highly probably result in ecological and health risks. Many biotechnologies for waste gases containing hydrophobic VOCs have been developed in recent years. However, these biological processes usually exhibit poor removal performances for hydrophobic VOCs du...

journal_title：Biotechnology advances

authors： Cheng Y,He H,Yang C,Zeng G,Li X,Chen H,Yu G

更新日期：2016-11-01 00:00:00

abstract：:Pigments (mainly carotenoids) are important nutraceuticals known for their potent anti-oxidant activities and have been used extensively as high end health supplements. Microalgae are the most promising sources of natural carotenoids and are devoid of the toxic effects associated with synthetic derivatives. Compared t...

journal_title：Biotechnology advances

authors： Hu J,Nagarajan D,Zhang Q,Chang JS,Lee DJ

更新日期：2018-01-01 00:00:00

abstract：:The diversity of natural compounds is essential for their mechanism of action. The source, structures and structure activity relationship of natural compounds contributed to the development of new classes of chemotherapy agents for over 40 years. The availability of combinatorial chemistry and high-throughput screenin...

journal_title：Biotechnology advances

authors： Mazumder A,Cerella C,Diederich M

更新日期：2018-11-01 00:00:00

abstract：:The beta-lactam antibiotics have been serving mankind for over 70 years. Despite this old age, they continue to provide health to the world population by virtue of industrial production and discoveries of new secondary metabolite molecules with useful activities. Sales of these remarkable compounds have reached over $...

journal_title：Biotechnology advances

authors： Ozcengiz G,Demain AL

更新日期：2013-03-01 00:00:00

abstract：:Fungi are notoriously prolific producers of secondary metabolites including nonribosomal peptides (NRPs). The structural complexity of NRPs grants them interesting activities such as antibiotic, anti-cancer, and anti-inflammatory properties. The discovery of these compounds with attractive activities can be achieved b...

journal_title：Biotechnology advances

authors： Vassaux A,Meunier L,Vandenbol M,Baurain D,Fickers P,Jacques P,Leclère V

更新日期：2019-12-01 00:00:00