Abstract：
:Hydrolysis of the whey protein alpha-lactalbumin with a specific serine protease has been shown to result in regular nanotubes of approximately 20 nm in outer diameter and reaching several mum in length. Tubular assembly depends on the concentration of protein as this determines how far the hydrolysis proceeds. A concentration of 30 g L(-1) is a prerequisite for tubular formation, as is a minimum concentration of calcium. At lower protein concentrations calcium-independent formation of linear fibrils (approximately 5 nm in diameter) is favoured. Possible applications of alpha-lactalbumin nanotubes include use as a viscosifier and gelling agent and also pharmaceutical utilization (such as targeted drug release) and use in nanotechnology can be envisioned.
journal_name
Biotechnol Advjournal_title
Biotechnology advancesauthors
Ipsen R,Otte Jdoi
10.1016/j.biotechadv.2007.07.006subject
Has Abstractpub_date
2007-11-01 00:00:00pages
602-5issue
6eissn
0734-9750issn
1873-1899pii
S0734-9750(07)00091-2journal_volume
25pub_type
杂志文章,评审abstract：:Actinomycetes are one of the most valuable sources of natural products with industrial and medicinal importance. After more than half a century of exploitation, it has become increasingly challenging to find novel natural products with useful properties as the same known compounds are often repeatedly re-discovered wh...
journal_title：Biotechnology advances
pub_type： 杂志文章,评审
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journal_title：Biotechnology advances
pub_type： 杂志文章,评审
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journal_title：Biotechnology advances
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journal_title：Biotechnology advances
pub_type： 杂志文章,评审
doi：10.1016/j.biotechadv.2008.03.005
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pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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journal_title：Biotechnology advances
pub_type： 杂志文章,评审
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更新日期：2018-01-01 00:00:00
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journal_title：Biotechnology advances
pub_type： 杂志文章,评审
doi：10.1016/j.biotechadv.2009.11.006
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journal_title：Biotechnology advances
pub_type： 杂志文章,评审
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pub_type： 杂志文章
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journal_title：Biotechnology advances
pub_type： 杂志文章,评审
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journal_title：Biotechnology advances
pub_type： 杂志文章,评审
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更新日期：2004-11-01 00:00:00
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journal_title：Biotechnology advances
pub_type： 杂志文章,评审
doi：10.1016/j.biotechadv.2019.04.002
更新日期：2019-01-01 00:00:00
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journal_title：Biotechnology advances
pub_type： 杂志文章
doi：10.1016/s0734-9750(02)00020-4
更新日期：2002-12-01 00:00:00
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journal_title：Biotechnology advances
pub_type： 杂志文章,评审
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更新日期：2015-12-01 00:00:00
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journal_title：Biotechnology advances
pub_type： 杂志文章,评审
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journal_title：Biotechnology advances
pub_type： 杂志文章,评审
doi：10.1016/j.biotechadv.2013.05.010
更新日期：2013-12-01 00:00:00
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journal_title：Biotechnology advances
pub_type： 杂志文章
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journal_title：Biotechnology advances
pub_type： 杂志文章,评审
doi：10.1016/j.biotechadv.2012.12.005
更新日期：2013-09-01 00:00:00
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journal_title：Biotechnology advances
pub_type： 杂志文章,评审
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更新日期：2020-01-01 00:00:00
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journal_title：Biotechnology advances
pub_type： 杂志文章
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更新日期：1990-01-01 00:00:00
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journal_title：Biotechnology advances
pub_type： 杂志文章,评审
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journal_title：Biotechnology advances
pub_type： 杂志文章
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journal_title：Biotechnology advances
pub_type： 杂志文章
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journal_title：Biotechnology advances
pub_type： 杂志文章,评审
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更新日期：2018-01-01 00:00:00
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journal_title：Biotechnology advances
pub_type： 杂志文章
doi：10.1016/0734-9750(93)90411-f
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journal_title：Biotechnology advances
pub_type： 杂志文章,评审
doi：10.1016/j.biotechadv.2005.04.001
更新日期：2005-07-01 00:00:00
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journal_title：Biotechnology advances
pub_type： 杂志文章,评审
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更新日期：2015-09-01 00:00:00
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journal_title：Biotechnology advances
pub_type： 杂志文章,评审
doi：10.1016/j.biotechadv.2012.07.005
更新日期：2012-11-01 00:00:00
