Abstract:
:Packed bed cultivation systems have potential for widespread application in solid-state cultivation (SSC), but they are poorly characterized. The effects of particle size and substrate loading on the growth of Rhizopus oligosporus on sago-beads in packed bed bioreactors were investigated. Pressure drop and protein were monitored as indicators of fungal growth in cultivations performed in a large column (4.9 cm internal diameter and 60 cm height) and a system of small columns (4.2 cm internal diameter and 5.2 cm height). The differential pressure drop increased to a maximum between 34 and 44 h and then decreased again. The maximum differential pressure drop attained was greatest for the smallest particle size and for the lower substrate loadings. However, since the protein content continued to increase throughout the cultivation, pressure drop could not be used to monitor growth directly.
journal_name
Biotechnol Advjournal_title
Biotechnology advancesauthors
Gumbira-Sa'id E,Greenfield PF,Mitchell DA,Doelle HWdoi
10.1016/0734-9750(93)90029-msubject
Has Abstractpub_date
1993-01-01 00:00:00pages
599-610issue
3eissn
0734-9750issn
1873-1899pii
0734-9750(93)90029-Mjournal_volume
11pub_type
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