A unified theory for upscaling aerobic granular sludge sequencing batch reactors.

abstract：:Phenotypic profiling of natural, engineered or synthetic cells has increasingly become a bottleneck in the mining and engineering of cell factories. Single-cell phenotyping technologies are highly promising for tackling this hurdle, yet ideally they should allow non-invasive live-cell probing, be label-free, provide l...

journal_title：Biotechnology advances

authors： He Y,Wang X,Ma B,Xu J

更新日期：2019-11-01 00:00:00

abstract：:Actinomycetes are one of the most valuable sources of natural products with industrial and medicinal importance. After more than half a century of exploitation, it has become increasingly challenging to find novel natural products with useful properties as the same known compounds are often repeatedly re-discovered wh...

journal_title：Biotechnology advances

authors： Palazzotto E,Tong Y,Lee SY,Weber T

更新日期：2019-11-01 00:00:00

abstract：:Basic and applied research on microbial cellulases, hemicellulases and pectinases has not only generated significant scientific knowledge but has also revealed their enormous potential in biotechnology. At present, cellulases and related enzymes are used in food, brewery and wine, animal feed, textile and laundry, pul...

journal_title：Biotechnology advances

authors： Bhat MK

更新日期：2000-08-01 00:00:00

abstract：:Enzymes are essential and ubiquitous biocatalysts involved in various metabolic pathways and used in many industrial processes. Here, we reframe enzymes not just as biocatalysts transforming bioproducts but also as sensitive probes for exploring the structure and composition of complex bioproducts, like meat tissue, d...

journal_title：Biotechnology advances

authors： Bourlieu C,Astruc T,Barbe S,Berrin JG,Bonnin E,Boutrou R,Hugouvieux V,Le Feunteun S,Paës G

更新日期：2020-01-01 00:00:00

abstract：:Competitive sustainable production in industry demands new and better biocatalysts, optimized bioprocesses and cost-effective product recovery. Our review sheds light on the progress made for the individual steps towards these goals, starting with the discovery of new enzymes and their corresponding genes. The enzymes...

journal_title：Biotechnology advances

authors： Wiltschi B,Cernava T,Dennig A,Galindo Casas M,Geier M,Gruber S,Haberbauer M,Heidinger P,Herrero Acero E,Kratzer R,Luley-Goedl C,Müller CA,Pitzer J,Ribitsch D,Sauer M,Schmölzer K,Schnitzhofer W,Sensen CW,Soh J,Steine

更新日期：2020-01-01 00:00:00

abstract：:Ribosomally synthesized peptides with antimicrobial properties (antimicrobial peptides-AMPs) are produced by eukaryotes and prokaryotes and represent crucial components of their defense systems against microorganisms. Although they differ in structure, they are nearly all cationic and very often amphiphilic, which ref...

journal_title：Biotechnology advances

authors： Papagianni M

更新日期：2003-09-01 00:00:00

abstract：:In the biological milieu of a cell, soluble crowding molecules and rigid confined environments strongly influence whether the protein is properly folded, intrinsically disordered proteins assemble into distinct phases, or a denatured or aggregated protein species is favored. Such crowding and confinement factors act t...

journal_title：Biotechnology advances

authors： Simpson LW,Good TA,Leach JB

更新日期：2020-01-01 00:00:00

abstract：:Integrins are cell adhesion receptors predominantly important during normal and tumor angiogenesis. A sequence present on several extracellular matrix proteins composed of Arg-Gly-Asp (RGD) has attracted attention due to its role in cell adhesion mediated by integrins. The development of ligands that can bind to integ...

journal_title：Biotechnology advances

authors： Rocha LA,Learmonth DA,Sousa RA,Salgado AJ

更新日期：2018-01-01 00:00:00

abstract：:The beta-lactam antibiotics have been serving mankind for over 70 years. Despite this old age, they continue to provide health to the world population by virtue of industrial production and discoveries of new secondary metabolite molecules with useful activities. Sales of these remarkable compounds have reached over $...

journal_title：Biotechnology advances

authors： Ozcengiz G,Demain AL

更新日期：2013-03-01 00:00:00

abstract：:Phytoremediation has emerged as a green, passive, solar energy driven and cost effective approach for environmental cleanup when compared to physico-chemical and even other biological methods. Textile dyes and effluents are condemned as one of the worst polluters of our precious water bodies and soils. They are well k...

journal_title：Biotechnology advances

authors： Khandare RV,Govindwar SP

更新日期：2015-12-01 00:00:00

abstract：:Although almost every U.S. pulp mill has a biological wastewater treatment system, these systems based on bacteria, are largely ineffective in the removal of color. For this reason, we have attempted to utilize Phanerochaete chrysosporium, a fungus known to degrade lignin, as the primary organism in a novel waste trea...

journal_title：Biotechnology advances

authors： Joyce TW,Chang H,Campbell AG Jr,Gerrard ED,Kirk TK

更新日期：1984-01-01 00:00:00

abstract：:Next generation sequencing is in the process of evolving from a technology used for research purposes to one which is applied in clinical diagnostics. Recently introduced high throughput and benchtop instruments offer fully automated sequencing runs at a lower cost per base and faster assay times. In turn, the complex...

journal_title：Biotechnology advances

authors： Hess JF,Kohl TA,Kotrová M,Rönsch K,Paprotka T,Mohr V,Hutzenlaub T,Brüggemann M,Zengerle R,Niemann S,Paust N

更新日期：2020-01-01 00:00:00

abstract：:Due to the over-harvesting and deterioration of wild populations, the ever-growing crustacean market is increasingly reliant on aquaculture, driving the need for better management techniques. Since most cultured crustacean species exhibit sexually dimorphic growth patterns, the culture of monosex populations (either a...

journal_title：Biotechnology advances

authors： Ventura T,Sagi A

更新日期：2012-11-01 00:00:00

abstract：:Yersinia pestis, the causative agent of bubonic and pneumonic plague, is an extremely virulent bacterium but there are currently no approved vaccines for protection against this organism. Plants represent an economical and safer alternative to fermentation-based expression systems for the production of therapeutic pro...

journal_title：Biotechnology advances

authors： Alvarez ML,Cardineau GA

更新日期：2010-01-01 00:00:00

abstract：:Biopharmaceuticals present the fastest growing segment in the pharmaceutical industry, with an ever widening scope of applications. Whole plants as well as contained plant cell culture systems are being explored for their potential as cheap, safe, and scalable production hosts. The first plant-derived biopharmaceutica...

journal_title：Biotechnology advances

authors： Karg SR,Kallio PT

更新日期：2009-11-01 00:00:00

abstract：:The concept of the Truncated Light-harvesting chlorophyll Antenna (TLA) size, as a tool by which to maximize sunlight utilization and photosynthetic productivity in microalgal mass cultures or high-density plant canopies, is discussed. TLA technology is known to improve sunlight-to-product energy conversion efficienci...

journal_title：Biotechnology advances

authors： Kirst H,Melis A

更新日期：2014-01-01 00:00:00

abstract：:For many proteins and peptides, disulfide bridges are prerequisite for their proper biological function. Many commercialized proteins are crosslinked by disulfide bridges that increase their resistance to destructive effects of extreme environment used in industrial processes or protect protein-based therapeutics from...

journal_title：Biotechnology advances

authors： Bulaj G

更新日期：2005-01-01 00:00:00

abstract：:Lactic acid, the most important hydroxycarboxylic acid, is now commercially produced by the fermentation of sugars present in biomass. In addition to its use in the synthesis of biodegradable polymers, lactic acid can be regarded as a feedstock for the green chemistry of the future. Different potentially useful chemic...

journal_title：Biotechnology advances

authors： Gao C,Ma C,Xu P

更新日期：2011-11-01 00:00:00

abstract：:Heart valve tissue engineering could be a possible solution for the limitations of mechanical and biological prostheses, which are commonly used for heart valve replacement. In tissue engineering, cells are seeded into a 3-dimensional platform, termed the scaffold, to make the engineered tissue construct. However, mim...

journal_title：Biotechnology advances

authors： Jana S,Lerman A

更新日期：2015-12-01 00:00:00

abstract：:We review the recent development of mobile detection instruments used for medical diagnostics, and consider the relative advantages of approaches that utilize the internal sensing capabilities of commercially available mobile communication devices (such as smartphones and tablet computers) compared to those that utili...

journal_title：Biotechnology advances

authors： Kwon L,Long KD,Wan Y,Yu H,Cunningham BT

更新日期：2016-05-01 00:00:00

abstract：:Vitrification is a new approach to oocyte and embryo cryoconservation. It consists in the solidification of a solution caused not by crystallization, but by a drastic increase in viscosity during cooling. The application of this approach to cryoconservation of oocytes and embryos of different species depends upon the ...

journal_title：Biotechnology advances

authors： Smorag Z,Gajda B

更新日期：1994-01-01 00:00:00

abstract：:A rapidly growing body of experimental evidence has begun to shed light on the wide ranging molecular mechanisms which modulate intra- and inter-cellular communications. A substantial quantity of the available knowledge has only been uncovered in recent years, and we are learning that donor cells release nanovesicles,...

journal_title：Biotechnology advances

authors： Farooqi AA,Desai NN,Qureshi MZ,Librelotto DRN,Gasparri ML,Bishayee A,Nabavi SM,Curti V,Daglia M

更新日期：2018-01-01 00:00:00

abstract：:Grassland is of major importance for agricultural production and provides valuable ecosystem services. Its impact is likely to rise in changing socio-economic and climatic environments. High yielding forage grass species are major components of sustainable grassland production. Understanding the genome structure and f...

journal_title：Biotechnology advances

authors： Kopecký D,Studer B

更新日期：2014-01-01 00:00:00

abstract：:One of the major bottlenecks in automation and process control of industrial bioprocesses is the lack of suitable sensing devices to accurately measure the concentrations of biomolecules. The measurement of ions (e.g., H(+), NH(4)(+)) and gases (e.g., O(2), CO(2), NH(3)) using standard ion-selective and gas sensing el...

journal_title：Biotechnology advances

authors： Graham A,Moo-Young M

更新日期：1985-01-01 00:00:00

abstract：:Vaccines represent a special class of drugs, capable of stimulating immune system responses against pathogens and tumors. Vaccine development is a lengthy process that includes expensive laboratory experiments in order to assess safety and effectiveness. As the efficacy of a vaccine was demonstrated by biological/chem...

journal_title：Biotechnology advances

authors： Pappalardo F,Pennisi M,Castiglione F,Motta S

更新日期：2010-01-01 00:00:00

abstract：:The degradation of plant biomass is a major challenge towards the production of bio-based compounds and materials. As key lignocellulolytic enzyme producers, filamentous fungi represent a promising reservoir to tackle this challenge. Among them, the coprophilous ascomycete Podospora anserina has been used as a model o...

journal_title：Biotechnology advances

authors： Couturier M,Tangthirasunun N,Ning X,Brun S,Gautier V,Bennati-Granier C,Silar P,Berrin JG

更新日期：2016-09-01 00:00:00

abstract：:Pigments (mainly carotenoids) are important nutraceuticals known for their potent anti-oxidant activities and have been used extensively as high end health supplements. Microalgae are the most promising sources of natural carotenoids and are devoid of the toxic effects associated with synthetic derivatives. Compared t...

journal_title：Biotechnology advances

authors： Hu J,Nagarajan D,Zhang Q,Chang JS,Lee DJ

更新日期：2018-01-01 00:00:00

abstract：:Bovine chymosin, an aspartyl protease extracted from abomasum of suckling calves, is synthesized in vivo as preprochymosin and secreted as prochymosin which is autocatalytically activated to chymosin. Chymosin is bilobular, with Asp 32 and Asp 215 acting as the catalytic residues. Chymosin A and chymosin B have pH opt...

journal_title：Biotechnology advances

authors： Mohanty AK,Mukhopadhyay UK,Grover S,Batish VK

更新日期：1999-09-01 00:00:00

abstract：:The byproduct of cheese-producing industries, cheese whey, is considered as an environmental pollutant due to its high BOD and COD concentrations. The high organic load of whey arises from the presence of residual milk nutrients. As demand for milk-derived products is increasing, it leads to increased production of wh...

journal_title：Biotechnology advances

authors： Yadav JS,Yan S,Pilli S,Kumar L,Tyagi RD,Surampalli RY

更新日期：2015-11-01 00:00:00

abstract：:Monoclonal antibodies (MCAs) have found widespread applications in livestock production. Although the generation of murine MCAs is at present a routine, the production of homologous MCAs, especially important for in vivo applications, is still hampered by the lack of efficient homologous fusion partners for immortaliz...

journal_title：Biotechnology advances

authors： Van Der Lende T

更新日期：1994-01-01 00:00:00