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Surface display of antibodies.

Abstract：

:To screen antibody libraries that contain many millions of different clones, a selection system is required with an efficiency comparable to that of the immune system. This can be achieved by displaying antibodies on the surface of microorganisms containing the antibody's gene, analogous to the expression of the IgM antigen receptor on the surface of unactivated B-lymphocytes. Specific clones can then be selected using immobilized antigens. The minor coat protein of filamentous phages, pIII, which initiates the infection of E.coli by binding to their F-pili, and the major coat protein, pVIII, have been used as carriers for displaying antibodies on the phage surface. Recombinant antibodies have also been targeted to the cell surface of bacteria by fusing them with outer membrane components derived from lipoproteins, OmpA and an IgA protease. However, only the pIII system has been routinely used for screening antibody libraries. Here we describe the various antibody surface display systems and the screening of antibody libraries generated from the gene repertoire of lymphocytes and by gene synthesis. Finally, we have made a short comparison of the bacterial production of Fabs versus single chain antibodies (scFv).

journal_name

Biotechnol Adv

journal_title

Biotechnology advances

authors

Little M,Breitling F,Micheel B,Dübel S

doi

10.1016/0734-9750(94)90023-x

subject

Has Abstract

pub_date

1994-01-01 00:00:00

pages

539-55

issue

3

eissn

0734-9750

issn

1873-1899

pii

073497509490023X

journal_volume

12

pub_type

杂志文章

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