Abstract：
:"Molecular farming" in plants with significant advantages in cost and safety is touted as a promising platform for the production of complex pharmaceutical proteins. While whole-plant produced biopharmaceuticals account for a significant portion of the preclinical and clinical pipeline, plant cell suspension culture, which integrates the merits of whole-plant systems with those of microbial fermentation, is emerging as a more compliant alternative "factory". However, low protein productivity remains a major obstacle that limits extensive commercialization of plant cell bioproduction platform. This review highlights the advantages and recent progress in plant cell culture technology and outlines viable strategies at both the biological and process engineering levels for advancing the economic feasibility of plant cell-based protein production. Approaches to overcome and solve the associated challenges of this culture system that include non-mammalian glycosylation and genetic instability will also be discussed.
journal_name
Biotechnol Advjournal_title
Biotechnology advancesauthors
Xu J,Ge X,Dolan MCdoi
10.1016/j.biotechadv.2011.01.002subject
Has Abstractpub_date
2011-05-01 00:00:00pages
278-99issue
3eissn
0734-9750issn
1873-1899pii
S0734-9750(11)00003-6journal_volume
29pub_type
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