Biotransformation of sterols: selective cleavage of the side chain.

abstract：:Quantitative real-time PCR (qPCR) has been widely used in recent environmental microbial ecology studies as a tool for detecting and quantifying microorganisms of interest, which aids in better understandings of the complexity of wastewater microbial communities. Although qPCR can be used to provide more specific and ...

journal_title：Biotechnology advances

authors： Kim J,Lim J,Lee C

更新日期：2013-12-01 00:00:00

abstract：:Worldwide, colorectal cancer (CRC) remains a major cancer type and leading cause of death. Unfortunately, current medical treatments are not sufficient due to lack of effective therapy, adverse side effects, chemoresistance and disease recurrence. In recent decades, epidemiologic observations have highlighted the asso...

journal_title：Biotechnology advances

authors： Afrin S,Giampieri F,Gasparrini M,Forbes-Hernández TY,Cianciosi D,Reboredo-Rodriguez P,Zhang J,Manna PP,Daglia M,Atanasov AG,Battino M

更新日期：2020-01-01 00:00:00

abstract：:To screen antibody libraries that contain many millions of different clones, a selection system is required with an efficiency comparable to that of the immune system. This can be achieved by displaying antibodies on the surface of microorganisms containing the antibody's gene, analogous to the expression of the IgM a...

journal_title：Biotechnology advances

authors： Little M,Breitling F,Micheel B,Dübel S

更新日期：1994-01-01 00:00:00

abstract：:A rapidly growing body of experimental evidence has begun to shed light on the wide ranging molecular mechanisms which modulate intra- and inter-cellular communications. A substantial quantity of the available knowledge has only been uncovered in recent years, and we are learning that donor cells release nanovesicles,...

journal_title：Biotechnology advances

authors： Farooqi AA,Desai NN,Qureshi MZ,Librelotto DRN,Gasparri ML,Bishayee A,Nabavi SM,Curti V,Daglia M

更新日期：2018-01-01 00:00:00

abstract：:Biomass, a renewable, sustainable and carbon dioxide neutral resource, has received widespread attention in the energy market as an alternative to fossil fuels. Thermal-chemical conversion of biomass to produce biofuels is a promising technology with many commercial applications. This paper reviewed the state-of-the-a...

journal_title：Biotechnology advances

authors： Ma L,Wang T,Liu Q,Zhang X,Ma W,Zhang Q

更新日期：2012-07-01 00:00:00

abstract：:The assessment of ecological risk in genetically modified (GM) biological systems is critically important for decision-making and public acceptance. Cellular automata (CA) provide a potential modeling and simulation framework for representing relationships and interspecies interactions both temporally and spatially. I...

journal_title：Biotechnology advances

authors： Yang J,Wang ZR,Yang DL,Yang Q,Yan J,He MF

更新日期：2009-11-01 00:00:00

abstract：:The world population now is 6.7 billion and is predicted to reach 9 billion by 2050. Such a rapid growing population has tremendously increased the challenge for food security. Obviously, it is impossible for traditional agriculture to ensure the food security, while plant biotechnology offers considerable potential t...

journal_title：Biotechnology advances

authors： Wang B,Zhang Z,Yin Z,Feng C,Wang Q

更新日期：2012-05-01 00:00:00

abstract：:Although natural sources have long been exploited for astaxanthin production, it is still uncertain if natural astaxanthin can be produced at lower cost than that of synthetic astaxanthin or not. In order to give a comprehensive cost analysis of astaxanthin production from Haematococcus, a pilot plant with two large s...

journal_title：Biotechnology advances

authors： Li J,Zhu D,Niu J,Shen S,Wang G

更新日期：2011-11-01 00:00:00

abstract：:Mitochondrial DNA (mtDNA) mutations have been involved in disease, aging and cancer and furthermore exploited for evolutionary and forensic investigation. When investigating mtDNA mutations the peculiar aspects of mitochondrial genetics, such as heteroplasmy and threshold effect, require suitable approaches which must...

journal_title：Biotechnology advances

authors： Kurelac I,Lang M,Zuntini R,Calabrese C,Simone D,Vicario S,Santamaria M,Attimonelli M,Romeo G,Gasparre G

更新日期：2012-01-01 00:00:00

abstract：:Nucleoside derivatives are a class of compounds that have attracted intense interest in biotechnology and medicine. Use of biocatalysts opens exciting opportunities for selective synthesis of many nucleoside derivatives, and such an approach offers simplicity, exquisite selectivity and environmentally benign processes...

journal_title：Biotechnology advances

authors： Li N,Smith TJ,Zong MH

更新日期：2010-05-01 00:00:00

abstract：:For many proteins and peptides, disulfide bridges are prerequisite for their proper biological function. Many commercialized proteins are crosslinked by disulfide bridges that increase their resistance to destructive effects of extreme environment used in industrial processes or protect protein-based therapeutics from...

journal_title：Biotechnology advances

authors： Bulaj G

更新日期：2005-01-01 00:00:00

abstract：:Although the history of the golden spice turmeric (Curcuma longa) goes back thousands of years, it is only within the past century that we learned about the chemistry of its active component, curcumin. More than 6000 articles published within the past two decades have discussed the molecular basis for the antioxidant,...

journal_title：Biotechnology advances

authors： Prasad S,Gupta SC,Tyagi AK,Aggarwal BB

更新日期：2014-11-01 00:00:00

abstract：:Tissue maceration was generally elucidated by the action of endo-polygalacturonase and endo-pectate or -pectin lyase (endo-PAL or -PNL). In a process of screening of Erwinia and Pseudomonas strains for enzymatic pulping of pectocellulosic bast fibers, it was found that their PAL productivity was not completely related...

journal_title：Biotechnology advances

authors： Kobayashi Y,Komae K,Tanabe H,Matsuo R

更新日期：1988-01-01 00:00:00

abstract：:Plant oil based industrial oleochemistry leads to a large side stream of crude glycerol, which offers itself as a low price carbon source for microbial chemical production. Compared to sugar, glycerol is more reduced and less microorganisms are able to use it as carbon source. An interesting feature of glycerol conver...

journal_title：Biotechnology advances

authors： Russmayer H,Egermeier M,Kalemasi D,Sauer M

更新日期：2019-11-01 00:00:00

abstract：:Monogenic diseases are often severe, life-threatening disorders for which lifelong palliative treatment is the only option. Over the last two decades, a number of strategies have been devised with the aim to treat these diseases with a genetic approach. Gene therapy has been under development for many years, yet suffe...

journal_title：Biotechnology advances

authors： Wong GK,Chiu AT

更新日期：2010-11-01 00:00:00

abstract：:Herbal remedies were the first medicines used by humans due to the many pharmacologically active secondary metabolites produced by plants. Some of these metabolites inhibit cell division and can therefore be used for the treatment of cancer, e.g. the mitostatic drug paclitaxel (Taxol). The ability of plants to produce...

journal_title：Biotechnology advances

authors： Buyel JF

更新日期：2018-01-01 00:00:00

abstract：:The concept of the Truncated Light-harvesting chlorophyll Antenna (TLA) size, as a tool by which to maximize sunlight utilization and photosynthetic productivity in microalgal mass cultures or high-density plant canopies, is discussed. TLA technology is known to improve sunlight-to-product energy conversion efficienci...

journal_title：Biotechnology advances

authors： Kirst H,Melis A

更新日期：2014-01-01 00:00:00

abstract：:We investigated the solid particle flow characteristics and biomass gasification in a clapboard-type internal circulating fluidized bed reactor. The effect of fluidization velocity on particle circulation rate and pressure distribution in the bed showed that fluidization velocities in the high and low velocity zones w...

journal_title：Biotechnology advances

authors： Zhou ZQ,Ma LL,Yin XL,Wu CZ,Huang LC,Wang C

更新日期：2009-09-01 00:00:00

abstract：:Interest in biobutanol, a sustainable vehicle fuel, is increasing due to rising oil prices and concerns of surrounding climate change and the energy crisis. However, the costs of biobutanol with conventional ABE fermentation by Clostridium are higher than the cost of butanol from today's petrochemical processes. Two m...

journal_title：Biotechnology advances

authors： Huang H,Liu H,Gan YR

更新日期：2010-09-01 00:00:00

abstract：:In recent years the study of root phenotypic plasticity in response to sub-optimal environmental factors and the genetic control of these responses have received renewed attention. As a path to increased productivity, in particular for low fertility soils, several applied research projects worldwide target the improve...

journal_title：Biotechnology advances

authors： Postma JA,Schurr U,Fiorani F

更新日期：2014-01-01 00:00:00

abstract：:Enormous sequence information is available in public databases as a result of sequencing of diverse crop genomes. It is important to use this genomic information for the identification and isolation of novel and superior alleles of agronomically important genes from crop gene pools to suitably deploy for the developme...

journal_title：Biotechnology advances

authors： Kumar GR,Sakthivel K,Sundaram RM,Neeraja CN,Balachandran SM,Rani NS,Viraktamath BC,Madhav MS

更新日期：2010-07-01 00:00:00

abstract：:Bovine chymosin, an aspartyl protease extracted from abomasum of suckling calves, is synthesized in vivo as preprochymosin and secreted as prochymosin which is autocatalytically activated to chymosin. Chymosin is bilobular, with Asp 32 and Asp 215 acting as the catalytic residues. Chymosin A and chymosin B have pH opt...

journal_title：Biotechnology advances

authors： Mohanty AK,Mukhopadhyay UK,Grover S,Batish VK

更新日期：1999-09-01 00:00:00

abstract：:Long-chain polyunsaturated fatty acids (LC-PUFAs) especially ω-3 fatty acids provide significant health benefits for human beings. However, ω-3 LC-PUFAs cannot be synthesized de novo in mammals. Traditionally, ω-3 LC-PUFAs are extracted from marine fish, and their production depends on sea fishing, which has not met e...

journal_title：Biotechnology advances

authors： Diao J,Song X,Guo T,Wang F,Chen L,Zhang W

更新日期：2020-01-01 00:00:00

abstract：:The population of sub-Saharan Africa is at risk from multiple, poverty-related endemic diseases. HIV and malaria are the most prevalent, but they disproportionately affect different groups of people, i.e. HIV predominantly affects sexually-active adults whereas malaria has a greater impact on children and pregnant wom...

journal_title：Biotechnology advances

authors： Vamvaka E,Twyman RM,Christou P,Capell T

更新日期：2014-05-01 00:00:00

abstract：:The ability to use progenitor cells for regenerative medicine remains an evolving but elusive clinical goal. A serious obstacle towards widespread use of stem cells for tissue regeneration is the challenges that face these cells when they are placed in vivo into a wound for therapy. These environments are hypoxic, aci...

journal_title：Biotechnology advances

authors： Hyun JS,Tran MC,Wong VW,Chung MT,Lo DD,Montoro DT,Wan DC,Longaker MT

更新日期：2013-09-01 00:00:00

abstract：:Integrins are cell adhesion receptors predominantly important during normal and tumor angiogenesis. A sequence present on several extracellular matrix proteins composed of Arg-Gly-Asp (RGD) has attracted attention due to its role in cell adhesion mediated by integrins. The development of ligands that can bind to integ...

journal_title：Biotechnology advances

authors： Rocha LA,Learmonth DA,Sousa RA,Salgado AJ

更新日期：2018-01-01 00:00:00

abstract：:Dihydroxyacetone is extensively used in cosmetic industry as an artificial suntan besides having clinical and biological applications. Thus, it is important to meet the commercial demand of dihydroxyacetone at an economical and qualitative level. Microbial route of production is found to be more favorable for dihydrox...

journal_title：Biotechnology advances

authors： Mishra R,Jain SR,Kumar A

更新日期：2008-07-01 00:00:00

abstract：:The increasing awareness of the energy-environment nexus is compelling the development of technologies that reduce environmental impacts during energy production as well as energy consumption during environmental remediation. Countries spend billions in pollution cleanup projects, and new technologies with low energy ...

journal_title：Biotechnology advances

authors： Wang H,Luo H,Fallgren PH,Jin S,Ren ZJ

更新日期：2015-05-01 00:00:00

abstract：:The aldopentose D-xylose is one of the most abundant sugars in plant biomass and its efficient microbial utilization is of fundamental importance in the overall bioconversion of lignocellulosic materials into liquid fuels and chemicals. The discovery of pentose-fermenting yeasts in the early 1980's led to world wide i...

journal_title：Biotechnology advances

authors： Webb SR,Lee H

更新日期：1990-01-01 00:00:00

abstract：:Polyamines (PAs) are ubiquitous biogenic amines that have been implicated in diverse cellular functions in widely distributed organisms. In plants, mutant and transgenic plants with altered activity pointed to their involvement with different abiotic and biotic stresses. Furthermore, microarray, transcriptomic and pro...

journal_title：Biotechnology advances

authors： Hussain SS,Ali M,Ahmad M,Siddique KH

更新日期：2011-05-01 00:00:00