Abstract：
:Agrin and neuregulin are broadly expressed molecules that have significant developmental roles. Here we review the diverse temporal and spatial expression patterns and functions of these molecules and the impact that dysregulation may have on a number of disease states. Many know agrin as a modulator of synaptogenesis and the neuregulins for their prominent role in breast cancer; this review elaborates on many of the other proposed functions for these molecules both in the nervous system and elsewhere. In several instances we discuss the possible use of agrin, neuregulin and related molecules as therapeutic agents.
journal_name
Biotechnol Advjournal_title
Biotechnology advancesauthors
Williams S,Ryan C,Jacobson Cdoi
10.1016/j.biotechadv.2007.11.003subject
Has Abstractpub_date
2008-05-01 00:00:00pages
187-201issue
3eissn
0734-9750issn
1873-1899pii
S0734-9750(07)00133-4journal_volume
26pub_type
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