Naturally occurring compounds in differentiation based therapy of cancer.

Abstract:

:Differentiation of cancer cells entails the reversion of phenotype from malignant to the original. The conversion to cell type characteristic for another tissue is named transdifferentiation. Differentiation/transdifferentiation of malignant cells in high grade tumor mass could serve as a nonaggressive approach that potentially limits tumor progression and augments chemosensitivity. While this therapeutic strategy is already being used for treatment of hematological cancers, its feasibility for solid malignancies is still debated. We will presently discuss the natural compounds that show these properties, with focus on anthraquinones from Aloe vera, Senna, Rheum sp. and hop derived prenylflavonoids.

journal_name

Biotechnol Adv

journal_title

Biotechnology advances

authors

Mijatović S,Bramanti A,Nicoletti F,Fagone P,Kaluđerović GN,Maksimović-Ivanić D

doi

10.1016/j.biotechadv.2018.04.001

subject

Has Abstract

pub_date

2018-11-01 00:00:00

pages

1622-1632

issue

6

eissn

0734-9750

issn

1873-1899

pii

S0734-9750(18)30073-9

journal_volume

36

pub_type

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