Abstract：
:The control of hepatitis B virus (HBV) infection is a challenging task, specifically in developing countries there is limited access to diagnostics and antiviral treatment mainly due to high costs and insufficient healthcare infrastructure. Although the current diagnostic technologies can reliably detect HBV, they are relatively laborious, impractical and require expensive resources that are not suitable for resource-limited settings. Advances in micro/nanotechnology are pioneering the development of new generation methodologies in diagnosis and screening of HBV. Owing to combination of nanomaterials (metal/inorganic nanoparticles, carbon nanotubes, etc.) with microfabrication technologies, utilization of miniaturized sensors detecting HBV and other viruses from ultra-low volume of blood, serum and plasma is realized. The state-of-the-art microfluidic devices with integrated nanotechnologies potentially allow for inexpensive HBV screening at low cost. This review aims to highlight recent advances in nanotechnology and microfabrication processes that are employed for developing point-of-care (POC) HBV assays.
journal_name
Biotechnol Advjournal_title
Biotechnology advancesauthors
Yildiz UH,Inci F,Wang S,Toy M,Tekin HC,Javaid A,Lau DT,Demirci Udoi
10.1016/j.biotechadv.2014.11.003subject
Has Abstractpub_date
2015-01-01 00:00:00pages
178-190issue
1eissn
0734-9750issn
1873-1899pii
S0734-9750(14)00178-5journal_volume
33pub_type
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