Assembly of non-natural electron transfer conduits in the cytochrome P450 system: a critical assessment and update of artificial redox constructs amenable to exploitation in biotechnological areas.

abstract：:Yeast strains Y1, Y4 and Y7 demonstrated high conversion efficiencies for sugars and high abilities to tolerate or metabolize inhibitors in dilute-acid lignocellulosic hydrolysates. Strains Y1 and Y4 completely consumed the glucose within 24 h in dilute-acid lignocellulosic hydrolysate during in situ detoxification, a...

journal_title：Biotechnology advances

authors： Tian S,Zhou G,Yan F,Yu Y,Yang X

更新日期：2009-09-01 00:00:00

abstract：:The kinetic resolution of racemates and desymmetrization are the most common approaches to the preparation of enantiomerically enriched compounds. These procedures allow the access of high valuable, chiral building blocks for many purposes in academic or industrial R&D endeavors. Nevertheless, the scope of stereochemi...

journal_title：Biotechnology advances

authors： Cunha RL,Ferreira EA,Oliveira CS,Omori ÁT

更新日期：2015-09-01 00:00:00

abstract：:Compared with the better-studied canonical amino acids, the distribution, metabolism and functions of natural non-canonical amino acids remain relatively obscure. Natural non-canonical amino acids have been mainly discovered in plants as secondary metabolites that perform diversified physiological functions. Due to th...

journal_title：Biotechnology advances

authors： Zou H,Li L,Zhang T,Shi M,Zhang N,Huang J,Xian M

更新日期：2018-11-15 00:00:00

abstract：:Citric acid is the principal organic acid found in citrus fruits. To meet increasing demands it is produced from carbohydrate feedstock by fermentation with the fungus Aspergillus niger and the yeasts of Candida spp. Effect of various fermentation conditions and the biochemistry of citric acid formation by A. niger ha...

journal_title：Biotechnology advances

authors： Grewal HS,Kalra KL

更新日期：1995-01-01 00:00:00

abstract：:Small molecule metabolites secreted by pathological processes can act as molecular biomarkers for clinical diagnosis. In vitro detection of the metabolites such as glucose and reactive oxygen species is of great significance for precise screening, monitoring and prognosis of metabolic disorders and relevant diseases s...

journal_title：Biotechnology advances

authors： Xiao F,Wang L,Duan H

更新日期：2016-05-01 00:00:00

abstract：:Industrial biotechnology is reliant on native pathway engineering or foreign pathway introduction for efficient biosynthesis of target products. Chromosomal integration, with intrinsic genetic stability, is an indispensable step for reliable expression of homologous or heterologous genes and pathways in large-scale an...

journal_title：Biotechnology advances

authors： Li L,Liu X,Wei K,Lu Y,Jiang W

更新日期：2019-01-01 00:00:00

abstract：:Enzymes are essential and ubiquitous biocatalysts involved in various metabolic pathways and used in many industrial processes. Here, we reframe enzymes not just as biocatalysts transforming bioproducts but also as sensitive probes for exploring the structure and composition of complex bioproducts, like meat tissue, d...

journal_title：Biotechnology advances

authors： Bourlieu C,Astruc T,Barbe S,Berrin JG,Bonnin E,Boutrou R,Hugouvieux V,Le Feunteun S,Paës G

更新日期：2020-01-01 00:00:00

abstract：:Bacteria produce a large number of different halogenated secondary metabolites. Haloperoxidases are believed to be the enzymes responsible for the halogenation reaction. Two classes of haloperoxidases, heme and nonheme, were isolated from different bacteria and their role in the biosynthesis of halogenated secondary m...

journal_title：Biotechnology advances

authors： Van Pée KH

更新日期：1990-01-01 00:00:00

abstract：:We review the recent development of mobile detection instruments used for medical diagnostics, and consider the relative advantages of approaches that utilize the internal sensing capabilities of commercially available mobile communication devices (such as smartphones and tablet computers) compared to those that utili...

journal_title：Biotechnology advances

authors： Kwon L,Long KD,Wan Y,Yu H,Cunningham BT

更新日期：2016-05-01 00:00:00

abstract：:Grassland is of major importance for agricultural production and provides valuable ecosystem services. Its impact is likely to rise in changing socio-economic and climatic environments. High yielding forage grass species are major components of sustainable grassland production. Understanding the genome structure and f...

journal_title：Biotechnology advances

authors： Kopecký D,Studer B

更新日期：2014-01-01 00:00:00

abstract：:Biomass, a renewable, sustainable and carbon dioxide neutral resource, has received widespread attention in the energy market as an alternative to fossil fuels. Thermal-chemical conversion of biomass to produce biofuels is a promising technology with many commercial applications. This paper reviewed the state-of-the-a...

journal_title：Biotechnology advances

authors： Ma L,Wang T,Liu Q,Zhang X,Ma W,Zhang Q

更新日期：2012-07-01 00:00:00

abstract：:DNA vaccination has been widely explored to develop new, alternative and efficient vaccines for cancer immunotherapy. DNA vaccines offer several benefits such as specific targeting, use of multiple genes to enhance immunity and reduced risk compared to conventional vaccines. Rapid developments in molecular biology and...

journal_title：Biotechnology advances

authors： Iurescia S,Fioretti D,Fazio VM,Rinaldi M

更新日期：2012-01-01 00:00:00

abstract：:Volatile organic compounds (VOCs) emitted to the environment highly probably result in ecological and health risks. Many biotechnologies for waste gases containing hydrophobic VOCs have been developed in recent years. However, these biological processes usually exhibit poor removal performances for hydrophobic VOCs du...

journal_title：Biotechnology advances

authors： Cheng Y,He H,Yang C,Zeng G,Li X,Chen H,Yu G

更新日期：2016-11-01 00:00:00

abstract：:Due to the over-harvesting and deterioration of wild populations, the ever-growing crustacean market is increasingly reliant on aquaculture, driving the need for better management techniques. Since most cultured crustacean species exhibit sexually dimorphic growth patterns, the culture of monosex populations (either a...

journal_title：Biotechnology advances

authors： Ventura T,Sagi A

更新日期：2012-11-01 00:00:00

abstract：:There is considerable interest in recent years in the bioconversion of forestry and agricultural residues into ethanol and value-added chemicals. High ethanol yields from lignocellulosic residues are dependent on efficient use of all the available sugars including glucose and xylose. The well-known fermentative yeast ...

journal_title：Biotechnology advances

authors： Chu BC,Lee H

更新日期：2007-09-01 00:00:00

abstract：:Bradyrhizobium elkanii produces rhizobitoxine, an enol-ether amino acid, which has been regarded as a phytotoxin because it causes chlorosis in soybeans. However, recent studies have revealed that rhizobitoxine plays a positive role in establishing symbiosis between B. elkanii and host legumes: rhizobitoxine enhances ...

journal_title：Biotechnology advances

authors： Sugawara M,Okazaki S,Nukui N,Ezura H,Mitsui H,Minamisawa K

更新日期：2006-07-01 00:00:00

abstract：:Phenotypic profiling of natural, engineered or synthetic cells has increasingly become a bottleneck in the mining and engineering of cell factories. Single-cell phenotyping technologies are highly promising for tackling this hurdle, yet ideally they should allow non-invasive live-cell probing, be label-free, provide l...

journal_title：Biotechnology advances

authors： He Y,Wang X,Ma B,Xu J

更新日期：2019-11-01 00:00:00

abstract：:Parasitic nematodes (roundworms) of livestock have major economic impact globally. In spite of the diseases caused by these nematodes and some advances in the design of new therapeutic agents (anthelmintics) and attempts to develop vaccines against some of them, there has been limited progress in the establishment of ...

journal_title：Biotechnology advances

authors： Roeber F,Jex AR,Gasser RB

更新日期：2013-12-01 00:00:00

abstract：:Enormous sequence information is available in public databases as a result of sequencing of diverse crop genomes. It is important to use this genomic information for the identification and isolation of novel and superior alleles of agronomically important genes from crop gene pools to suitably deploy for the developme...

journal_title：Biotechnology advances

authors： Kumar GR,Sakthivel K,Sundaram RM,Neeraja CN,Balachandran SM,Rani NS,Viraktamath BC,Madhav MS

更新日期：2010-07-01 00:00:00

abstract：:The diversity of natural compounds is essential for their mechanism of action. The source, structures and structure activity relationship of natural compounds contributed to the development of new classes of chemotherapy agents for over 40 years. The availability of combinatorial chemistry and high-throughput screenin...

journal_title：Biotechnology advances

authors： Mazumder A,Cerella C,Diederich M

更新日期：2018-11-01 00:00:00

abstract：:Circulating tumor cells (CTCs) are a major contributor of cancer metastases and hold a promising prognostic significance in cancer detection. Performing functional and molecular characterization of CTCs provides an in-depth knowledge about this lethal disease. Researchers are making efforts to design devices and devel...

journal_title：Biotechnology advances

authors： Sharma S,Zhuang R,Long M,Pavlovic M,Kang Y,Ilyas A,Asghar W

更新日期：2018-01-01 00:00:00

abstract：:A major feature of twenty-first century medical research is the development of therapeutic strategies that use 'biologics' (large molecules, usually engineered proteins) and living cells instead of, or as well as, the small molecules that were the basis of pharmacology in earlier eras. The high power of these techniqu...

journal_title：Biotechnology advances

authors： Davies JA,Ireland S,Harding S,Sharman JL,Southan C,Dominguez-Monedero A

更新日期：2019-12-01 00:00:00

abstract：:Cell-free protein synthesis systems enable the direct in vitro expression of proteins from template DNA or RNA. Use of biochemical and bioengineering techniques has greatly improved the yields and productivities of cell-free systems. In some cases, the yields approach the in vivo levels. Moreover, in vitro systems are...

journal_title：Biotechnology advances

authors： Nakano H,Yamane T

更新日期：1998-03-01 00:00:00

abstract：:Although rational method and global technique have been successfully applied in strain improvement respectively, the demand for engineering complex phenotypes required combinatorial approach. The technology of genome shuffling has been presented as a novel whole genome engineering approach for the rapid improvement of...

journal_title：Biotechnology advances

authors： Gong J,Zheng H,Wu Z,Chen T,Zhao X

更新日期：2009-11-01 00:00:00

abstract：:Pichia pastoris, a methylotrophic yeast, is an established system for the production of heterologous proteins, particularly biopharmaceuticals and industrial enzymes. To maximise and optimise the production of recombinant products, recent molecular research has focused on numerous issues including the design of expres...

journal_title：Biotechnology advances

authors： Looser V,Bruhlmann B,Bumbak F,Stenger C,Costa M,Camattari A,Fotiadis D,Kovar K

更新日期：2015-11-01 00:00:00

abstract：:This paper addresses the circumstances of germplasm contamination and updates on transmission of pathogenic agents by embryos produced in vitro and by associated techniques. It has been shown that some pathogenic agents might have been associated with the follicular oocytes and oviductal cells, collected for in vitro ...

journal_title：Biotechnology advances

authors： Bielanski A

更新日期：1997-01-01 00:00:00

abstract：:Fungi are notoriously prolific producers of secondary metabolites including nonribosomal peptides (NRPs). The structural complexity of NRPs grants them interesting activities such as antibiotic, anti-cancer, and anti-inflammatory properties. The discovery of these compounds with attractive activities can be achieved b...

journal_title：Biotechnology advances

authors： Vassaux A,Meunier L,Vandenbol M,Baurain D,Fickers P,Jacques P,Leclère V

更新日期：2019-12-01 00:00:00

abstract：:Biotechnology techniques involving plant tissue culture and recombinant DNA technologies are powerful tools that can complement conventional breeding and expedite Capsicum improvement. The rate of progress in Capsicum is relatively slower than other members of Solanaceae because of its high genotypic dependence and re...

journal_title：Biotechnology advances

authors： Kothari SL,Joshi A,Kachhwaha S,Ochoa-Alejo N

更新日期：2010-01-01 00:00:00

abstract：:Developments in plant genetic engineering technology will shortly permit the commercial introduction of transgenic crop varieties resistant to a number of non-selective herbicides. High levels of tolerance have been achieved both by overexpression of a target protein and by modification of that target to an insensitiv...

journal_title：Biotechnology advances

authors： Quinn JP

更新日期：1990-01-01 00:00:00

abstract：:Cyclodextrins (CDs) are a family of cyclic oligosaccharides that are composed of alpha-1,4-linked glucopyranose subunits. Cyclodextrins are produced from starch by enzymatic degradation. These macrocyclic carbohydrates with apolar internal cavities can form complexes with and solubilize many normally water-insoluble c...

journal_title：Biotechnology advances

authors： Singh M,Sharma R,Banerjee UC

更新日期：2002-12-01 00:00:00