Abstract：
:Microencapsulation of ketoprofen using Eudragit RS and RL (acrylic resins) was investigated based on the dispersion system of ketoprofen-containing acetone in liquid paraffin. Aluminium tristearate was used as an additive for the preparation of microcapsules. Good reproducibility was observed in the microencapsulation and the resulting microcapsules were uniform, free-flowing particles. The phase diagram of ketoprofen-Eudragit RS or RL-aluminium tristearate indicated that it is only in a very limited region that spherical microcapsules ranging from 250 to 1000 microns in diameter could be prepared. Instrumental analysis using an energy dispersive-type X-ray microanalyser and a scanning electron microscope showed that aluminium tristearate was localized near the surface of the microcapsules. From these results, it was presumed that aluminium tristearate reduces the phase tension between Eudragit microcapsules and liquid paraffin. The dissolution patterns of ketoprofen from Eudragit RS and RL microcapsules were independent of the pH of the dissolution medium, and the dissolution rates were considerably lower than those from ketoprofen powders.
journal_name
J Microencapsuljournal_title
Journal of microencapsulationauthors
Goto S,Kawata M,Nakamura M,Maekawa K,Aoyama Tdoi
10.3109/02652048609021799subject
Has Abstractpub_date
1986-10-01 00:00:00pages
293-304issue
4eissn
0265-2048issn
1464-5246journal_volume
3pub_type
杂志文章abstract：PURPOSE:This investigation was undertaken to develop glyceryl monostearate (Geleol)-based solid lipid nanoparticles (SLNs) of a hydrophilic drug ciprofloxacin HCl. METHODS:Hansen's solubility parameter study was carried out in screening of a suitable carrier and solvent system. Subsequently, SLNs were prepared by solv...
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journal_title：Journal of microencapsulation
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journal_title：Journal of microencapsulation
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journal_title：Journal of microencapsulation
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journal_title：Journal of microencapsulation
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journal_title：Journal of microencapsulation
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journal_title：Journal of microencapsulation
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更新日期：2004-06-01 00:00:00
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journal_title：Journal of microencapsulation
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journal_title：Journal of microencapsulation
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更新日期：1997-07-01 00:00:00
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abstract：:A kind of electronic ink, which is supported on indium-tin-oxide (ITO) glass before polymerization, is prepared using urea and formaldehyde resin as wall materials, in which TiO(2) modified with PMMA are dispersed in tetrachloroethylene (TCE) using a mixture of oil blue dyes and charge control additive (span80). Rotar...
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abstract：:An extrusion-based encapsulation process has been developed for making salt grain-sized iron premix for salt fortification. The first step of extrusion agglomeration process has been studied and reported previously. The focus of this study is on the optimisation of the colour-masking and polymer coating steps. Several...
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