Nifedipine encapsulated core-shell type nanoparticles based on poly(gamma-benzyl L-glutamate)/poly(ethylene glycol) diblock copolymers.

Abstract:

:The diblock copolymers based on PBLG and PEO (GE) were synthesized and characterized. Nanoparticles showed spherical shape from the observations of TEM and approved core-shell structure. Drug contents were increased with use of higher initial drug concentration and higher Mw of GE. Nifedipine (NFD) release rate was slower in longer PBLG chain length and higher NFD contents than short PBLG chain length and lower drug contents of NFD due to the hydrophobic interaction between PBLG domain and NFD.

journal_name

J Microencapsul

authors

Jeong YI,Sun HS,Shim YH,Kim C,Park SH,Choi KC,Cho CS

doi

10.1080/02652040410001729241

subject

Has Abstract

pub_date

2004-06-01 00:00:00

pages

445-53

issue

4

eissn

0265-2048

issn

1464-5246

pii

R7MCBBC93EHR2CTL

journal_volume

21

pub_type

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