Abstract:
:Latex particles coated with either amino or carboxyl groups were labelled with 99mTc. Two labelling methods were used: (1) direct labelling with tin reduction and (2) ligand exchange with tin pyrophosphate. Labelling efficiency and the radiochemical impurities were determined by thin-layer chromatography. Effect of [Sn2+] and pH on labelling yield was investigated to find the optimum labelling conditions. 99mTc-labelled latexes were administered orally to six normal subjects, and scintigrams from the abdomen were obtained at 1, 3, 6, and 24 h. Whole-body scintigrams were also taken by a gamma-camera. The first method was found to be efficient for carboxyl coated latexes and the second method for both types, giving > 98 per cent labelling efficiency. Labelled latexes were stable up to 24 h of testing at RT (> 99 per cent labelled). Scintigraphic studies showed that the labelled particles remained in GIT (98.11 +/- 0.92 per cent at 6 h) without dissociation of the label. No radioactivity was observed in the thyroid, stomach (at late images) and urinary bladder. This study demonstrated that latex particles coated with either amino or carboxyl groups can be efficiently labelled with 99mTc and used in the studies of GI function.
journal_name
J Microencapsuljournal_title
Journal of microencapsulationauthors
Ercan MT,Tuncel SA,Caner BE,Pişkin Edoi
10.3109/02652049309015313subject
Has Abstractpub_date
1993-01-01 00:00:00pages
67-76issue
1eissn
0265-2048issn
1464-5246journal_volume
10pub_type
杂志文章abstract::To improve poor water solubility of cyclosporine A (CsA), hydroxypropyl-beta-cyclodextrin (HPβCD) was incorporated into the nanoparticle formulation. Solid complexes of CsA with HPβCD in different ratios were prepared by the kneading method. CsA containing alone or in combination with HPβCD in poly-lactide-co-glycolid...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652048.2012.668961
更新日期:2012-01-01 00:00:00
abstract::Microcapsules were prepared through an interfacial cross-linking process using terephthaloylchloride and applied to mixtures of a protein (human serum albumin or gelatin) and a polysaccharide. Their properties were compared with those of microcapsules prepared from the protein alone. Morphological characteristics of m...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652049109069560
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abstract::Silica gel microspheres are ideal materials for bioencapsulation due to their mechanical properties, biocompatibility, and stability. Encapsulated cells are isolated from the environment and protected from predators, changes in pH, and osmotic stress. However methods for the production of silica gel microspheres suita...
journal_title:Journal of microencapsulation
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journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/026520499289149
更新日期:1999-03-01 00:00:00
abstract::A novel method for preparing the PLGA nanospheres with hydrophilic surface has been designed and characterized. Because of good solubility of tetraglycol in water, PLGA (poly(lactide-co-glycolide)) nanospheres were formed by spraying the PLGA/tetraglycol solution into water. The size of PLGA nanospheres was manipulate...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652040400000520
更新日期:2004-11-01 00:00:00
abstract::The purpose of this study was the preparation, optimisation and in vitro characterisation of PHBV and PLGA blend nanoparticles (NPs) for prolonged delivery of Teriparatide. Double emulsion solvent evaporation technique was employed for the fabrication of NPs. The nanoformulation was optimised using the Box-Behnken met...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652048.2016.1208296
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abstract::In this study, recombinant human interleukin-2 (rhIL-2) containing poly(lactic-co-glycolic acid) (PLGA) microparticles were prepared for pulmonary administration by modified w/o/w double emulsion solvent extraction method and the effects of various formulation parameters on the physicochemical properties of the microp...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652048.2011.599438
更新日期:2011-01-01 00:00:00
abstract:AIM:This study aimed to evaluate the protective effect of flaxseed mucilage on the co-extrusion microencapsulation of Lactobacillus rhamnosus GG. METHODS:Core flow rate, chitosan coating, and flaxseed mucilage concentration were optimised for the microencapsulation of L. rhamnosus. The microbeads were characterised an...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652048.2020.1863490
更新日期:2020-12-28 00:00:00
abstract::A biocompatible emulsification method has been developed for microencapsulation of live cells and enzymes within a calcium alginate matrix. Fabrication of alginate beads was achieved by premixing a sequestering agent (sodium polyphosphate) and the calcium source (calcium sulphate) with the hydrogel monomer prior to th...
journal_title:Journal of microencapsulation
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doi:10.3109/02652049509010294
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journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652049109071488
更新日期:1991-04-01 00:00:00
abstract::Chronic osteomyelitis is still the cause of many problems in orthopaedics in terms of therapy and infection persistence. Four-to-six week systemic antibiotic therapy is required along with bone and soft tissue debridement in the therapy of chronic osteomyelitis. Prolonged-release local antibiotic therapy has been take...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/0265204031000154179
更新日期:2003-11-01 00:00:00
abstract:AIM:To study the effect of poly(d,l-lactic-co-glycolic acid) (PLGA) microparticles (MPs) preparation techniques on particle physical characterization with special emphasis on burst drug release. METHODS:A basic drug clozapine was used in combination with acid-terminated PLGA. Two approaches for MP preparation were com...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652048.2014.913724
更新日期:2014-01-01 00:00:00
abstract::Proliposomes of ibuprofen were successfully prepared using effervescent granules as solid carriers of dried phospholipids along with other lipids (soyabean lecithin, stearylamine and cholesterol). Liposomes of regular size with uniform size distribution resulted when proliposomal formulations were hydrated under the e...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652049009040467
更新日期:1990-10-01 00:00:00
abstract::Chitosan microspheres were prepared by an emulsion-phase separation technique without the use of chemical cross-linking agents; alternatively, ionotropic gelation was employed in a w/o emulsion. The possibility of three kinds of anions (tripolyphosphate, citrate and sulphate) to interact with chitosan was investigated...
journal_title:Journal of microencapsulation
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doi:10.1080/02652040010000415
更新日期:2001-03-01 00:00:00
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journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652048.2012.714411
更新日期:2013-01-01 00:00:00
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journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652040110105337
更新日期:2002-05-01 00:00:00
abstract::Sub-100-nm nanoparticles were prepared from beta-lactoglobulin (BLG) with a narrow size distribution by a desolvation method using glutaraldehyde for cross-linking. With pre-heating of the BLG solution to 60 degrees C and subsequent pH readjustment to 9.0, nanoparticles of 59 +/- 5 nm were obtained with improved unifo...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652040601035143
更新日期:2006-12-01 00:00:00
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journal_title:Journal of microencapsulation
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doi:10.1080/02652040110055270
更新日期:2002-01-01 00:00:00
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journal_title:Journal of microencapsulation
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更新日期:1998-09-01 00:00:00
abstract::PLGA microspheres with high drug loading and high encapsulation efficiency were fabricated by a novel solvent evaporation process-in-situ S/O/W process. Insulin was dissolved in DMSO and dispersed into DCM to form fine particles due to an anti-solvent effect. The in-situ formed suspension was then added into an aqueou...
journal_title:Journal of microencapsulation
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journal_title:Journal of microencapsulation
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journal_title:Journal of microencapsulation
pub_type: 杂志文章
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更新日期:2007-12-01 00:00:00
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journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652048.2017.1409819
更新日期:2018-01-01 00:00:00
abstract::Different classes of excipients with potential for use in the design of novel pelletized formulations manufactured by extrusion-spheronization were examined using factorial experiments. Among the various silicates examined in a model mix with microcrystalline cellulose and lactose wetted with water, kaolin, talc and V...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652049709006817
更新日期:1997-09-01 00:00:00
abstract::The microencapsulation of drugs is gaining importance in many research activities. A common technique for preparing microcapsules is the solvent evaporation method which is simple but has a large number of reaction control parameters. This study reports the microcapsulation of allopurinol by the solvent evaporation me...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652049609026038
更新日期:1996-09-01 00:00:00
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journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652048.2010.523796
更新日期:2011-01-01 00:00:00
abstract::D,L-polylactic acid (PLA) microspheres containing quinidine base and quinidine sulphate were prepared by the solvent evaporation method. The present study was carried out to examine how various process parameters in the aqueous phase influenced the preparation and properties of PLA-microspheres. The amount of drug tha...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652048709021821
更新日期:1987-10-01 00:00:00
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journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652049409040444
更新日期:1994-03-01 00:00:00
abstract::The purpose of this study was to assess the antioxidant and anti-inflammatory potential of liposomal formulations enriched with Hypericum hookerianum (Hyp) aqueous extracts. Cotyledon segments derived from protocorms of H. hookerianum were cultured on Murashige and Skoog (MS) media supplemented with Kinetin (KN, 1 mgl...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652048.2019.1631400
更新日期:2019-09-01 00:00:00
abstract:PURPOSE:To develop a stable and reproducible modified release pellet formulation containing ibuprofen. METHODS:Using extrusion-spheronization technology to produce pellets. RESULTS:The percentage yield, size distribution and overall pellet shape within the desired size range of 1000-1400 microm was found to be depend...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652040500162535
更新日期:2005-09-01 00:00:00