Abstract：
:The entrapment of clofazimine (CLO) in a liposomal delivery system for topical application can protect it from absorption into the blood circulation and increase its residence time within the skin. This may reduce the very long mean period of leprosy treatment, as well as the side effects due to the long term administration of large doses of the drug. This investigation deals with critical parameters controlling the formulation and stabilization of liposomes with encapsulated CLO. The entrapment efficiency of CLO in liposomes was increased by altering the proportion of phosphatidyl choline (PC) and cholesterol (CHOL) in liposomes. The stability of liposomal suspensions and the liposomal gels (HPMC K4M) in terms of retention of CLO was measured at refrigeration temperature (2-8 degrees C), room temperature (25 +/- 2 degrees C) and body temperature (37 degrees C) for a period of 3 months. The results show that entrapment of CLO in liposomes can be increased by increasing the proportion of PC. However, the optimum encapsulation and retention of CLO was achieved only with a specific PC:CHOL molar ratio (5.13:1.00). An almost identical value of the entrapment efficiency was obtained when gel filtration and ultracentrifugation methods were used to separate the CLO-carrying liposomes from free drug. The effect of vortexing and sonication on the entrapment efficiency gave similar results, although the mean particle size was different. CLO liposomal gels were found to be stable at room temperature for up to 3 months.
journal_name
J Microencapsuljournal_title
Journal of microencapsulationauthors
Patel VB,Misra ANdoi
10.1080/026520499289077subject
Has Abstractpub_date
1999-05-01 00:00:00pages
357-67issue
3eissn
0265-2048issn
1464-5246journal_volume
16pub_type
杂志文章abstract：:The aim of the present study is to construct a type of polyion complex micelles made of PF127-PEI copolymer and cholic acid (CA) and to evaluate the potential of this type of micelles as a targeted drug delivery system for paclitaxel (PTX). To further improve the targeting capability of micelles, folate was also incor...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652048.2014.940010
更新日期：2014-01-01 00:00:00
abstract：:Cross-linked albumin microcapsules were prepared, using a polycondensation interfacial process. Doxorubicin was incorporated in these microcapsules by simple adsorption from aqueous solution. Increasing the extent of cross-linkage of the microcapsule walls by either increasing the cross-linking agent concentration or ...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652048809064170
更新日期：1988-07-01 00:00:00
abstract：:Emulsions of menhaden oil and sodium caseinate (NaCas) incorporating carbohydrates of varying dextrose equivalence (DE) were spray-dried to yield encapsulated fish oil powders. The effects of carbohydrate DE (5.5-38), core/wall ratio and NaCas/carbohydrate ratio on microencapsulation efficiency (ME) and oxidative stab...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/0265204031000151974
更新日期：2003-09-01 00:00:00
abstract：:Provision and maintenance of adequate concentrations of antibiotics at infection sites is very important in treating highly resistant infections. For diseases like implant related osteomyelitis (IRO) it is best to provide this locally via implanted drug formulations, as systemic administration of the antibiotic may no...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040110065413
更新日期：2002-03-01 00:00:00
abstract：:Moisture curing type self-healing microcapsules become more attractive, while instability of active core material crippled the efficiency of self-healing behaviour. Polyurea (PU)/melamine formaldehyde (MF) double-layered self-healing microcapsules containing isophorone diisocyanate (IPDI) core with high and stable cor...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652048.2016.1178352
更新日期：2016-06-01 00:00:00
abstract：:Latex particles coated with either amino or carboxyl groups were labelled with 99mTc. Two labelling methods were used: (1) direct labelling with tin reduction and (2) ligand exchange with tin pyrophosphate. Labelling efficiency and the radiochemical impurities were determined by thin-layer chromatography. Effect of [S...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652049309015313
更新日期：1993-01-01 00:00:00
abstract：CONTEXT:Coated whey protein micro-beads may improve probiotic protection and provide delayed cell-release mechanisms. OBJECTIVE:Lactobacillus rhamnosus GG was encapsulated in whey protein micro-beads by droplet extrusion with coating via electrostatic deposition: primary-polysaccharide and secondary-whey protein. MAT...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652048.2011.638994
更新日期：2012-01-01 00:00:00
abstract：:This work aimed to investigate the potential effect of cyclodextrin encapsulation on intrinsic ability of daidzein (DAD) and genistein (GEN) to inhibit the glycosaminoglycan (GAG) synthesis in fibroblasts originating from patients with mucopolysaccharidosis (MPS), type II and III. DAD or GEN encapsulation with either ...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652048.2017.1409819
更新日期：2018-01-01 00:00:00
abstract：:Polylactic acid microcapsules containing randomly distributed hydrocortisone particles were prepared. The rate of release of hydrocortisone from the microcapsules in pH 7.4 phosphate buffer was found to be largely increased by the presence of polysorbate 80, cetylpyridinium chloride, or aerosol OT in the dissolution m...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652048809036721
更新日期：1988-01-01 00:00:00
abstract：:The aim of this study was to design and develop microspheres of indomethacin with pH and transit time dependent release properties for achieving targeted delivery to the colon. Microspheres containing varying proportions of ethyl cellulose and Eudragit (L100 or S100) either alone or in combination were prepared using ...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040802424021
更新日期：2009-08-01 00:00:00
abstract：:This study optimized and evaluated the conditions for surface coating of microspheres using a spray-dryer. Four formulations of Bromophenol blue (BPB)-loaded albumin microspheres were prepared using a spray-dryer, cross-linked at different concentrations and time periods. One of the optimized formulations with the des...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040802476187
更新日期：2008-12-01 00:00:00
abstract：:Liposomes are known to be a potent adjuvant for a wide range of antigens, as well as appropriate antigen carriers for antibody generation response in vivo. In addition, liposomes are effective vehicles for peptides and proteins, thus enhancing their immunogenicity. Considering these properties of liposomes and the ant...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652048.2014.958203
更新日期：2015-01-01 00:00:00
abstract：:Objective: To improve the water solubility and enhance the oral bioavailability of gambogenic acid (GNA). Methods: GNA-phospholipid complex (GNA-PLC) micelles were successfully prepared by anti-solvent method. Results: The encapsulation efficiency of GNA-PLC micelles can reach 99.33 % (w/w). The average particle size ...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652048.2019.1656294
更新日期：2019-09-01 00:00:00
abstract：:The effects of different loading procedures of magnetic nanoparticles (MNs) on the structure and physicochemical properties of cisplatin magnetic liposomes were investigated by X-ray diffraction, infrared spectroscopy, transmission electron microscopy, and fluorescence spectroscopy. 1, 2-Dipalmitoyl-sn-glycero-3-Phosp...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652048.2012.692397
更新日期：2012-01-01 00:00:00
abstract：:Microspheres, including microcapsules and cells or beads, are widely used to produce many functional products. Information about their mechanical properties is essential to understanding their performance during manufacturing, processing and end-use applications. The mechanical characterization of microspheres require...
journal_title：Journal of microencapsulation
pub_type： 杂志文章,评审
doi：10.3109/02652048.2011.646331
更新日期：2012-01-01 00:00:00
abstract：:A novel method for preparing the PLGA nanospheres with hydrophilic surface has been designed and characterized. Because of good solubility of tetraglycol in water, PLGA (poly(lactide-co-glycolide)) nanospheres were formed by spraying the PLGA/tetraglycol solution into water. The size of PLGA nanospheres was manipulate...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040400000520
更新日期：2004-11-01 00:00:00
abstract：:The physical entrapment of a hydrophilic drug within degradable microspheres is generally difficult because of poor entrapment yield and/or fast release, depending on the microsphere fabrication method. In order to counter the effects of drug hydrophilicity, it is proposed to covalently attach the drug to lactic acid ...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/026520400417667
更新日期：2000-09-01 00:00:00
abstract：:Nanoencapsulation by spray drying was performed to protect and preserve antioxidant rich dietary polyphenols from green coffee beans. Nano-encapsulation of green coffee was done using maltodextrin as wall material. The nanoparticles were further characterised by zetasizer, differential scanning colorimetry, X-ray diff...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652048.2019.1692946
更新日期：2020-01-01 00:00:00
abstract：:Radioembolization is used in diagnostic imaging of the lungs and for radioembolization therapy of hepatic tumours. Presently, 99mTc labelled macroaggregates or microspheres of human serum albumin (HAM) are used for this purpose. Poly lactic acid (PLA) is biodegradable, like HAM, and, unlike HAM, is not a blood product...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/026520400405750
更新日期：2000-07-01 00:00:00
abstract：:Low molecular weight heparin (LMWH)-loaded flexible liposomes (flexosomes) were formulated for transdermal delivery, and their physicochemical and pharmacokinetic parameters were compared with LMWH-loaded ethosomes. Flexosomes had similar particle size compared with ethosomes, but their deformability was higher than t...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652048.2010.507880
更新日期：2011-01-01 00:00:00
abstract：:This study focuses on development and in vitro characterisation of a nasal delivery system based on uncoated or chitosan-coated solid lipid microparticles (SLMs) containing resveratrol, a natural anti-inflammatory molecule, as an effective alternative to the conventional steroidal drugs. The physico-chemical character...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652048.2016.1260659
更新日期：2016-12-01 00:00:00
abstract：:Chronic osteomyelitis is still the cause of many problems in orthopaedics in terms of therapy and infection persistence. Four-to-six week systemic antibiotic therapy is required along with bone and soft tissue debridement in the therapy of chronic osteomyelitis. Prolonged-release local antibiotic therapy has been take...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/0265204031000154179
更新日期：2003-11-01 00:00:00
abstract：PURPOSE:To develop a stable and reproducible modified release pellet formulation containing ibuprofen. METHODS:Using extrusion-spheronization technology to produce pellets. RESULTS:The percentage yield, size distribution and overall pellet shape within the desired size range of 1000-1400 microm was found to be depend...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040500162535
更新日期：2005-09-01 00:00:00
abstract：:The influence of drug particle size on the production of enteric beads by a polymer precipitation technique was investigated. Drug particle dimensions are known to play an important role in most microencapsulation techniques. Bead morphology was greatly influenced by drug particle size, and spherical shaped beads coul...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040050161729
更新日期：2000-11-01 00:00:00
abstract：:The objective of this study was to prepare a microparticulate drug delivery system being based on a new thiomer, namely a chitosan 2-iminothiolane conjugate (chitosan-TBA conjugate). Due to thiol groups being immobilized on chitosan, chitosan-TBA conjugate exhibits improved mucoadhesive and permeation enhancing proper...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040500162220
更新日期：2005-08-01 00:00:00
abstract：:The mechanism by which microcapsule aggregation is diminished in the presence of low concentrations of adjunct non-walling polymers such as polyisobutylene (PIB) in organic solvents is uncertain. It is here investigated by phase separation studies employing the non-solvent addition method (cyclohexane) in parallel wit...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652049009028419
更新日期：1990-01-01 00:00:00
abstract：:The objective of this study is to explore the influence of polyvinylpyrrolidone (PVP) quantity on the solubility, crystallinity and oral bioavailability of poorly water-soluble fenofibrate in solvent-evaporated microspheres. Numerous microspheres were prepared with fenofibrate, sodium lauryl sulphate (SLS) and PVP usi...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652048.2016.1194906
更新日期：2016-06-01 00:00:00
abstract：:Anal fissure is common and painful disease of anorectum. In this study, microparticles containing nifedipine and lidocaine HCl were prepared by spray drying and applied to bio-degradable and bio-stable tampons. Characterization of microparticles was determined by visual analyses, mass yield, particle size measurement,...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652048.2017.1393113
更新日期：2017-12-01 00:00:00
abstract：:The release behaviour of aspirin from spray-congealed hydrogenated soybean oil micro-pellets of different sizes was studied. The purpose of this study was to investigate the effect of particle size of micro-pellets on the drug release profile and mechanism. Micro-pellets produced were sieved into several fractions and...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040500100345
更新日期：2005-05-01 00:00:00
abstract：:Encapsulated vitro-derived apical buds of M.26 apple rootstock (Malus pumila Mill) can be employed for the formation of the synthetic seed. Satisfactory levels of conversion (plantlets from synthetic seed) can be achieved if there are adequate (i) rooting induction treatment, (ii) protocol of encapsulation, and (iii) ...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040110105337
更新日期：2002-05-01 00:00:00
