Oxprenolol release from bioadhesive gelatin/poly(acrylic acid) microspheres.

Abstract:

:Drug release from gelatin/poly(acrylic acid) oxprenolol-loaded microspheres has been evaluated using an in situ sink immersion method and a wetting method. The kinetics of drug release were analysed by applying the empirical exponential equation and by the calculation of the approximate contribution of the diffusional and relaxational mechanism to the anomalous release process by fitting the data to the coupled Fickian/Case II equation. The influence of glutaraldehyde cross-linking agent concentration, the poly(acrylic acid) content, the pH of the release medium and the particle size of the beads on the drug release kinetics were evaluated and discussed.

journal_name

J Microencapsul

authors

Leucuta SE,Ponchel G,Duchêne D

doi

10.3109/02652049709033835

subject

Has Abstract

pub_date

1997-07-01 00:00:00

pages

511-22

issue

4

eissn

0265-2048

issn

1464-5246

journal_volume

14

pub_type

杂志文章
  • Development of alpha-lipoic acid encapsulated chitosan monodispersed particles using an electrospray system: synthesis, characterisations and anti-inflammatory evaluations.

    abstract::This study demonstrates the feasibility of using a single-capillary electrospray (ES) system to generate novel alpha-lipoic acid encapsulated poly(ethylene oxide)-chitosan (ALA/PEO/CS) particles with a monodispersed diameter. Scanning electron microscopic images (SEM) and dynamic light scattering (DLS) results indicat...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章

    doi:10.3109/02652048.2013.863395

    authors: Bai MY,Hu YM

    更新日期:2014-01-01 00:00:00

  • Studies on the transport pathway of PBCA nanoparticles in ocular tissues.

    abstract::The transport pathway of PBCA nanoparticles through the rabbit cornea and conjunctiva was studied using fluorescence microscopy. Nanoparticles were produced by an emulsion-polymerization process, purified by a GPC procedure, and labelled with rhodamine 6G or propidium iodide as fluorescent laser dyes. The stability of...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章

    doi:10.3109/02652049109021873

    authors: Zimmer A,Kreuter J,Robinson JR

    更新日期:1991-10-01 00:00:00

  • Chitosan/gelatin microspheres prepared by modified emulsification and ionotropic gelation.

    abstract::Chitosan microspheres were prepared by an emulsion-phase separation technique without the use of chemical cross-linking agents; alternatively, ionotropic gelation was employed in a w/o emulsion. The possibility of three kinds of anions (tripolyphosphate, citrate and sulphate) to interact with chitosan was investigated...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章

    doi:10.1080/02652040010000415

    authors: Shu XZ,Zhu KJ

    更新日期:2001-03-01 00:00:00

  • Novel folated pluronic F127 modified liposomes for delivery of curcumin: preparation, release, and cytotoxicity.

    abstract::Aim: A novel folated pluronic F127 (FA-F127) was synthesised, so as to modify liposomes with FA group on the surface, and evaluate the effects of FA-F127 modification on the properties of the modified liposomes.Methods: FA was linked to one end of pluronic F127, via the terminal OH group, to obtain FA-F127 and the str...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章

    doi:10.1080/02652048.2020.1720030

    authors: Li Z,Xiong X,Peng S,Chen X,Liu W,Liu C

    更新日期:2020-05-01 00:00:00

  • Green coffee nanoparticles: optimisation, in vitro bioactivity and bio-release property.

    abstract::Nanoencapsulation by spray drying was performed to protect and preserve antioxidant rich dietary polyphenols from green coffee beans. Nano-encapsulation of green coffee was done using maltodextrin as wall material. The nanoparticles were further characterised by zetasizer, differential scanning colorimetry, X-ray diff...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章

    doi:10.1080/02652048.2019.1692946

    authors: Desai NM,Gilbert Stanley J,Murthy PS

    更新日期:2020-01-01 00:00:00

  • Ceramic encapsulation with polymer via co-axial electrohydrodynamic jetting.

    abstract::Co-flowing media of a polymeric solution (30 wt% polymethylsilsesquioxane in ethanol) and a ceramic suspension (10 wt% alumina in glycerol) were subjected to an electric field. The flow rates of the media (10-30 microL min(-1)) and the applied voltage (0-11 kV) were varied systematically during the experimentation by ...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章

    doi:10.3109/02652048.2010.489973

    authors: Nangrejo M,Ahmad Z,Edirisinghe M

    更新日期:2010-01-01 00:00:00

  • In vitro and in vivo evaluation of ranitidine hydrochloride ethyl cellulose floating microparticles.

    abstract::The real issue in the development of oral controlled release dosage forms is not just to prolong the delivery of drugs but also to prolong the presence of dosage forms in the stomach in order to improve the bioavailability of drugs with a 'narrow absorption window'. In the present study, an anti-ulcer drug, ranitidine...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章

    doi:10.1080/02652040801973101

    authors: Mastiholimath VS,Dandagi PM,Gadad AP,Mathews R,Kulkarni AR

    更新日期:2008-08-01 00:00:00

  • Water-in-oil-in-water double emulsions loaded with chlorogenic acid: release mechanisms and oxidative stability.

    abstract::Chlorogenic acid (CA) is a natural compound used as an antioxidant in the preparation of food, drugs, and cosmetics. Due to their low stability and bioavailability, many researchers have studied the encapsulation of CA in various delivery colloidal systems. The aim of this study was to evaluate the stability of water-...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章

    doi:10.1080/02652048.2018.1559246

    authors: Dima C,Dima S

    更新日期:2018-09-01 00:00:00

  • Liposomes as cyclosporin A carriers: positively charged lecithin-cholesterol liposomes associated with cyclosporin A do not inhibit biosynthesis of mitochondrial polyglycerophosphatides and microsomal phosphatidylinositol.

    abstract::Phosphatidylcholine (from egg yolk)-cholesterol-stearylamine (7:2:2.25, molar ratio) liposomes when associated with cyclosporin A (phosphatidylcholine:cyclosporin A = 2:0.07, molar ratio) do not inhibit significantly the biosynthesis of [3H]polyglycerophosphatides and [3H]phosphatidylinositol in mitochondrial and micr...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章

    doi:10.3109/02652048909098018

    authors: Stuhne-Sekalec L,Stanacev NZ

    更新日期:1989-04-01 00:00:00

  • Microencapsulation of Lactobacillus rhamnosus GG with flaxseed mucilage using co-extrusion technique.

    abstract:AIM:This study aimed to evaluate the protective effect of flaxseed mucilage on the co-extrusion microencapsulation of Lactobacillus rhamnosus GG. METHODS:Core flow rate, chitosan coating, and flaxseed mucilage concentration were optimised for the microencapsulation of L. rhamnosus. The microbeads were characterised an...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章

    doi:10.1080/02652048.2020.1863490

    authors: Lai K,How Y,Pui L

    更新日期:2020-12-28 00:00:00

  • Functionality of protective colloids affecting the formation, size uniformity and morphology of drug-free polylactic acid microspheres.

    abstract::Drug-free polylactic acid (PLA) microspheres were prepared by an emulsification-solvent evaporation technique using different types of protective colloids. The influence of five types of hydrophilic prolymers (polysaccharides, proteins, synthetic cellulose derivatives, synthetic nonionic polymers and surfactants) on t...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章

    doi:10.3109/02652049809006865

    authors: Lin SY,Chen KS,Teng HH

    更新日期:1998-05-01 00:00:00

  • Preparation and characterization of wormwood-oil-contained microcapsules.

    abstract::In recent years, wormwood has been successfully applied in various fields, such as flavouring agent, plant dye, insect repellent and medical product. Wormwood oil encapsulated microcapsules with continuous release behaviours would be further applied in the health care textiles. Here, wormwood oil encapsulated microcap...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章

    doi:10.1080/02652048.2020.1749320

    authors: Wang L,Li T,Xin B,Liu Y,Zhang F

    更新日期:2020-06-01 00:00:00

  • Fabrication of redox-responsive magnetic protein microcapsules from hen egg white by the sonochemical method.

    abstract::Redox-responsive magnetic protein microcapsules with Fe3O4 magnetic nanoparticles (MNPs) encapsulated inside have been obtained using a facile, cost-effective and fast sonochemical method from hen egg white proteins. Such prepared redox-responsive magnetic hen egg white protein microcapsules (MHEWPMCs) could be easily...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章

    doi:10.3109/02652048.2015.1073389

    authors: Zhong S,Cui X,Tian F

    更新日期:2015-01-01 00:00:00

  • Design of PEG-grafted-PLA nanoparticles as oral permeability enhancer for P-gp substrate drug model Famotidine.

    abstract::Bioavailability of oral drugs can be limited by an intestinal excretion process mediated by P-glycoprotein (P-gp). Polyethylene glycol (PEG) is a known P-gp inhibitor. Dispersion of Famotidine (a P-gp substrate) within PEGylated nanoparticles (NPs) was used to improve its oral bioavailability. In this work, we evaluat...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章

    doi:10.1080/02652048.2017.1290155

    authors: Mokhtar M,Gosselin P,Lacasse F,Hildgen P

    更新日期:2017-02-01 00:00:00

  • Formulation of rate-modulating pellets for the release of ibuprofen: an extrusion-spheronization process.

    abstract:PURPOSE:To develop a stable and reproducible modified release pellet formulation containing ibuprofen. METHODS:Using extrusion-spheronization technology to produce pellets. RESULTS:The percentage yield, size distribution and overall pellet shape within the desired size range of 1000-1400 microm was found to be depend...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章

    doi:10.1080/02652040500162535

    authors: Lutchman D,Dangor CM,Perumal D

    更新日期:2005-09-01 00:00:00

  • Influence of experimental parameters on the microencapsulation of a photopolymerizable phase.

    abstract::Conditions of microencapsulation by in situ polycondensation, using melamine-formaldehyde as wall material, are influenced by the chemical nature of the core to encapsulate. In our study concerning the encapsulation of a photopolymerizable phase containing an electrically charged compound, it was necessary to modify t...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章

    doi:10.3109/02652049309031522

    authors: Pernot JM,Brun H,Pouyet B,Sergent M,Phan-Tan-Luu R

    更新日期:1993-07-01 00:00:00

  • PLGA microspheres with high drug loading and high encapsulation efficiency prepared by a novel solvent evaporation technique.

    abstract::PLGA microspheres with high drug loading and high encapsulation efficiency were fabricated by a novel solvent evaporation process-in-situ S/O/W process. Insulin was dissolved in DMSO and dispersed into DCM to form fine particles due to an anti-solvent effect. The in-situ formed suspension was then added into an aqueou...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章

    doi:10.1080/02652040600687613

    authors: Bao W,Zhou J,Luo J,Wu D

    更新日期:2006-08-01 00:00:00

  • Preparation and characterization of vitamin-12 loaded biodegradable pH-sensitive microgels.

    abstract::This paper prepared novel biodegradable and pH-sensitive microgels based on Poly(epsilon-caprolactone)-Pluronic-Poly(epsilon-caprolactone)-dimethacrylate (PCFC-DMA), Poly(ethylene glycol) dimethacrylate (PEG-DMA) and methylacrylic acid (MAA) cross-linked with N,N'-methylenebisacrylamide (BIS), initiated by NaHSO(3), K...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章

    doi:10.3109/02652040802610827

    authors: Xu X,Fu S,Wang K,Jia W,Guo G,Zheng X,Dong P,Guo Q,Qian Z

    更新日期:2009-11-01 00:00:00

  • Polycarboxylic acid nanoparticles for ophthalmic drug delivery: an ex vivo evaluation with human cornea.

    abstract::In ophthalmic drug delivery, a major problem is retaining an adequate concentration of a therapeutic agent in the pre-corneal area. Polycarboxylic acid carriers such as polyacrylic acid and polyitaconic acid in sub-colloidal, nanoparticulate hydrogel form have a strong potential for sustained release of a drug in ocul...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章

    doi:10.1080/02652040400008515

    authors: De TK,Bergey EJ,Chung SJ,Rodman DJ,Bharali DJ,Prasad PN

    更新日期:2004-12-01 00:00:00

  • Sorption of 5-fluorouracil from aqueous solutions onto methyl methacrylate nanoparticles.

    abstract::The sorption of 5-fluorouracil from aqueous solutions onto poly(methyl methacrylate) was investigated. Linear sorption isotherms were obtained and no crystallinity of the nanoparticles after sorption was detectable by X-ray analysis indicating a partitioning of the drug into the polymer particles-forming a solid solut...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章

    doi:10.3109/02652048609031560

    authors: Yalabik-Kas HS,Kreuter J,Hincal AA,Speiser PP

    更新日期:1986-04-01 00:00:00

  • Influence of the surface properties of low contact angle surfactants on the body distribution of 14C-poly(methyl methacrylate) nanoparticles.

    abstract::The body distribution of surfactant-coated and non-coated poly(methyl methacrylate) nanoparticles with a size of 131 +/- 30 nm after intravenous injection into rats was investigated. The coating materials were poloxamine 904, poloxamine 908, poloxamine 1508, poloxamer 338, and Brij 35. These materials were preselected...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章

    doi:10.3109/02652049209021219

    authors: Tröster SD,Kreuter J

    更新日期:1992-01-01 00:00:00

  • Incorporation of the reovirus M cell attachment protein into small unilamellar vesicles: incorporation efficiency and binding capability to L929 cells in vitro.

    abstract::Neutral phosphatidylcholine/cholesterol (10 : 3) liposomes with the reovirus M cell attachment protein sigma 1 were made by means of detergent dialysis method. An immunological evaluation method revealed an incorporation efficiency (pg protein/microgram lipid) of 314. Binding studies with mouse fibroblasts (L929 cells...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章

    doi:10.3109/02652049009021848

    authors: Rubas W,Banerjea AC,Gallati H,Speiser PP,Joklik WK

    更新日期:1990-07-01 00:00:00

  • Optimisation of the microencapsulation of lavender oil by spray drying.

    abstract::Background: Lavender oil consists of around 100 components and is susceptible to volatilisation and degradation reactions. Aim: Microencapsulate lavender oil by spray drying using a biocompatible polymeric blend of gum acacia and maltodextrin to protect the oil components. Effect of total polymer content, oil loading,...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章

    doi:10.1080/02652048.2019.1620355

    authors: Burhan AM,Abdel-Hamid SM,Soliman ME,Sammour OA

    更新日期:2019-05-01 00:00:00

  • Effect of manufacturing conditions on the formation of double-walled polymer microspheres.

    abstract::This paper discusses the optimization of the solvent evaporation process to produce double-walled (DW) microspheres in a single-step. Five process variables were studied: polymer solution concentration, polymer weight ratio, polymer solution volume ratios, encapsulation temperature, and air flow rate across the top of...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章

    doi:10.1080/026520499289149

    authors: Leach K,Noh K,Mathiowitz E

    更新日期:1999-03-01 00:00:00

  • Microencapsulation of fragrant oil via in situ polymerization: effects of pH and melamine-formaldehyde molar ratio.

    abstract::Microcapsules containing fragrant oil (Foral oil) were synthesized via the in situ polymerization method using melamine-formaldehyde (M-F) as a wall material. The encapsulation efficiency and other physical properties were analysed with varying formaldehyde/melamine (F/M) mole ratio and pH of emulsion medium. The pH o...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章

    doi:10.1080/02652040210140472

    authors: Lee HY,Lee SJ,Cheong IW,Kim JH

    更新日期:2002-09-01 00:00:00

  • Emulsification preparation of calcium alginate beads in the presence of sequesterant.

    abstract::A biocompatible emulsification method has been developed for microencapsulation of live cells and enzymes within a calcium alginate matrix. Fabrication of alginate beads was achieved by premixing a sequestering agent (sodium polyphosphate) and the calcium source (calcium sulphate) with the hydrogel monomer prior to th...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章

    doi:10.3109/02652049509010294

    authors: Monshipouri M,Price RR

    更新日期:1995-05-01 00:00:00

  • Encapsulation of Sesbania grandiflora extract in polymeric micelles to enhance its solubility, stability, and antibacterial activity.

    abstract::Clinical applications of Sesbania grandiflora bark extract (SGE) are limited because of its poor water solubility and stability. SGE was loaded in micelles of Pluronics. In vitro and in vivo antibacterial and toxicity tests were investigated using broth dilution and silkworm model. Aqueous solubility of SGE was improv...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章

    doi:10.1080/02652048.2017.1284277

    authors: Anantaworasakul P,Okonogi S

    更新日期:2017-02-01 00:00:00

  • Preparation of chitosan microspheres using membrane emulsification and its size modelling.

    abstract::The chitosan microspheres were prepared by a membrane emulsification method with variations of the N2 gas pressure and the chitosan concentration. The pressure of N2 gas was varied within the range from 0.2 x 10(5) to 0.8 x 10(5) Pa at chitosan concentration 1.5 wt%. In addition, the concentration of chitosan was vari...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章

    doi:10.1080/02652040410001729304

    authors: Park SB,Jeon YJ,Haam S,Park HY,Kim WS

    更新日期:2004-08-01 00:00:00

  • Controlling the size of alginate gel beads by use of a high electrostatic potential.

    abstract::The effect of several parameters on the size of alginate beads produced by use of an electrostatic potential bead generator was examined. Parameters studied included needle diameter, electrostatic potential, alginate solution flow rate, gelling ion concentration and alginate concentration and viscosity, as well as alg...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章

    doi:10.1080/02652040210144234

    authors: Klokk TI,Melvik JE

    更新日期:2002-07-01 00:00:00

  • Physicochemical characterization of protamine-phosphorothioate nanoparticles.

    abstract::Protamine-oligonucleotide nanoparticles represent effective colloidal drug carriers for antisense phosphorothioate oligonucleotides (PTO). This study describes improvements in particle preparation and the physicochemical properties of the complexes prepared. The influence of component concentrations, length of the PTO...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章

    doi:10.1080/02652040400000504

    authors: Lochmann D,Vogel V,Weyermann J,Dinauer N,von Briesen H,Kreuter J,Schubert D,Zimmer A

    更新日期:2004-09-01 00:00:00