Abstract:
:Drug release from gelatin/poly(acrylic acid) oxprenolol-loaded microspheres has been evaluated using an in situ sink immersion method and a wetting method. The kinetics of drug release were analysed by applying the empirical exponential equation and by the calculation of the approximate contribution of the diffusional and relaxational mechanism to the anomalous release process by fitting the data to the coupled Fickian/Case II equation. The influence of glutaraldehyde cross-linking agent concentration, the poly(acrylic acid) content, the pH of the release medium and the particle size of the beads on the drug release kinetics were evaluated and discussed.
journal_name
J Microencapsuljournal_title
Journal of microencapsulationauthors
Leucuta SE,Ponchel G,Duchêne Ddoi
10.3109/02652049709033835subject
Has Abstractpub_date
1997-07-01 00:00:00pages
511-22issue
4eissn
0265-2048issn
1464-5246journal_volume
14pub_type
杂志文章abstract::This study demonstrates the feasibility of using a single-capillary electrospray (ES) system to generate novel alpha-lipoic acid encapsulated poly(ethylene oxide)-chitosan (ALA/PEO/CS) particles with a monodispersed diameter. Scanning electron microscopic images (SEM) and dynamic light scattering (DLS) results indicat...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652048.2013.863395
更新日期:2014-01-01 00:00:00
abstract::The transport pathway of PBCA nanoparticles through the rabbit cornea and conjunctiva was studied using fluorescence microscopy. Nanoparticles were produced by an emulsion-polymerization process, purified by a GPC procedure, and labelled with rhodamine 6G or propidium iodide as fluorescent laser dyes. The stability of...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652049109021873
更新日期:1991-10-01 00:00:00
abstract::Chitosan microspheres were prepared by an emulsion-phase separation technique without the use of chemical cross-linking agents; alternatively, ionotropic gelation was employed in a w/o emulsion. The possibility of three kinds of anions (tripolyphosphate, citrate and sulphate) to interact with chitosan was investigated...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652040010000415
更新日期:2001-03-01 00:00:00
abstract::Aim: A novel folated pluronic F127 (FA-F127) was synthesised, so as to modify liposomes with FA group on the surface, and evaluate the effects of FA-F127 modification on the properties of the modified liposomes.Methods: FA was linked to one end of pluronic F127, via the terminal OH group, to obtain FA-F127 and the str...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652048.2020.1720030
更新日期:2020-05-01 00:00:00
abstract::Nanoencapsulation by spray drying was performed to protect and preserve antioxidant rich dietary polyphenols from green coffee beans. Nano-encapsulation of green coffee was done using maltodextrin as wall material. The nanoparticles were further characterised by zetasizer, differential scanning colorimetry, X-ray diff...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652048.2019.1692946
更新日期:2020-01-01 00:00:00
abstract::Co-flowing media of a polymeric solution (30 wt% polymethylsilsesquioxane in ethanol) and a ceramic suspension (10 wt% alumina in glycerol) were subjected to an electric field. The flow rates of the media (10-30 microL min(-1)) and the applied voltage (0-11 kV) were varied systematically during the experimentation by ...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652048.2010.489973
更新日期:2010-01-01 00:00:00
abstract::The real issue in the development of oral controlled release dosage forms is not just to prolong the delivery of drugs but also to prolong the presence of dosage forms in the stomach in order to improve the bioavailability of drugs with a 'narrow absorption window'. In the present study, an anti-ulcer drug, ranitidine...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652040801973101
更新日期:2008-08-01 00:00:00
abstract::Chlorogenic acid (CA) is a natural compound used as an antioxidant in the preparation of food, drugs, and cosmetics. Due to their low stability and bioavailability, many researchers have studied the encapsulation of CA in various delivery colloidal systems. The aim of this study was to evaluate the stability of water-...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652048.2018.1559246
更新日期:2018-09-01 00:00:00
abstract::Phosphatidylcholine (from egg yolk)-cholesterol-stearylamine (7:2:2.25, molar ratio) liposomes when associated with cyclosporin A (phosphatidylcholine:cyclosporin A = 2:0.07, molar ratio) do not inhibit significantly the biosynthesis of [3H]polyglycerophosphatides and [3H]phosphatidylinositol in mitochondrial and micr...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652048909098018
更新日期:1989-04-01 00:00:00
abstract:AIM:This study aimed to evaluate the protective effect of flaxseed mucilage on the co-extrusion microencapsulation of Lactobacillus rhamnosus GG. METHODS:Core flow rate, chitosan coating, and flaxseed mucilage concentration were optimised for the microencapsulation of L. rhamnosus. The microbeads were characterised an...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652048.2020.1863490
更新日期:2020-12-28 00:00:00
abstract::Drug-free polylactic acid (PLA) microspheres were prepared by an emulsification-solvent evaporation technique using different types of protective colloids. The influence of five types of hydrophilic prolymers (polysaccharides, proteins, synthetic cellulose derivatives, synthetic nonionic polymers and surfactants) on t...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652049809006865
更新日期:1998-05-01 00:00:00
abstract::In recent years, wormwood has been successfully applied in various fields, such as flavouring agent, plant dye, insect repellent and medical product. Wormwood oil encapsulated microcapsules with continuous release behaviours would be further applied in the health care textiles. Here, wormwood oil encapsulated microcap...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652048.2020.1749320
更新日期:2020-06-01 00:00:00
abstract::Redox-responsive magnetic protein microcapsules with Fe3O4 magnetic nanoparticles (MNPs) encapsulated inside have been obtained using a facile, cost-effective and fast sonochemical method from hen egg white proteins. Such prepared redox-responsive magnetic hen egg white protein microcapsules (MHEWPMCs) could be easily...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652048.2015.1073389
更新日期:2015-01-01 00:00:00
abstract::Bioavailability of oral drugs can be limited by an intestinal excretion process mediated by P-glycoprotein (P-gp). Polyethylene glycol (PEG) is a known P-gp inhibitor. Dispersion of Famotidine (a P-gp substrate) within PEGylated nanoparticles (NPs) was used to improve its oral bioavailability. In this work, we evaluat...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652048.2017.1290155
更新日期:2017-02-01 00:00:00
abstract:PURPOSE:To develop a stable and reproducible modified release pellet formulation containing ibuprofen. METHODS:Using extrusion-spheronization technology to produce pellets. RESULTS:The percentage yield, size distribution and overall pellet shape within the desired size range of 1000-1400 microm was found to be depend...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652040500162535
更新日期:2005-09-01 00:00:00
abstract::Conditions of microencapsulation by in situ polycondensation, using melamine-formaldehyde as wall material, are influenced by the chemical nature of the core to encapsulate. In our study concerning the encapsulation of a photopolymerizable phase containing an electrically charged compound, it was necessary to modify t...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652049309031522
更新日期:1993-07-01 00:00:00
abstract::PLGA microspheres with high drug loading and high encapsulation efficiency were fabricated by a novel solvent evaporation process-in-situ S/O/W process. Insulin was dissolved in DMSO and dispersed into DCM to form fine particles due to an anti-solvent effect. The in-situ formed suspension was then added into an aqueou...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652040600687613
更新日期:2006-08-01 00:00:00
abstract::This paper prepared novel biodegradable and pH-sensitive microgels based on Poly(epsilon-caprolactone)-Pluronic-Poly(epsilon-caprolactone)-dimethacrylate (PCFC-DMA), Poly(ethylene glycol) dimethacrylate (PEG-DMA) and methylacrylic acid (MAA) cross-linked with N,N'-methylenebisacrylamide (BIS), initiated by NaHSO(3), K...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652040802610827
更新日期:2009-11-01 00:00:00
abstract::In ophthalmic drug delivery, a major problem is retaining an adequate concentration of a therapeutic agent in the pre-corneal area. Polycarboxylic acid carriers such as polyacrylic acid and polyitaconic acid in sub-colloidal, nanoparticulate hydrogel form have a strong potential for sustained release of a drug in ocul...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652040400008515
更新日期:2004-12-01 00:00:00
abstract::The sorption of 5-fluorouracil from aqueous solutions onto poly(methyl methacrylate) was investigated. Linear sorption isotherms were obtained and no crystallinity of the nanoparticles after sorption was detectable by X-ray analysis indicating a partitioning of the drug into the polymer particles-forming a solid solut...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652048609031560
更新日期:1986-04-01 00:00:00
abstract::The body distribution of surfactant-coated and non-coated poly(methyl methacrylate) nanoparticles with a size of 131 +/- 30 nm after intravenous injection into rats was investigated. The coating materials were poloxamine 904, poloxamine 908, poloxamine 1508, poloxamer 338, and Brij 35. These materials were preselected...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652049209021219
更新日期:1992-01-01 00:00:00
abstract::Neutral phosphatidylcholine/cholesterol (10 : 3) liposomes with the reovirus M cell attachment protein sigma 1 were made by means of detergent dialysis method. An immunological evaluation method revealed an incorporation efficiency (pg protein/microgram lipid) of 314. Binding studies with mouse fibroblasts (L929 cells...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652049009021848
更新日期:1990-07-01 00:00:00
abstract::Background: Lavender oil consists of around 100 components and is susceptible to volatilisation and degradation reactions. Aim: Microencapsulate lavender oil by spray drying using a biocompatible polymeric blend of gum acacia and maltodextrin to protect the oil components. Effect of total polymer content, oil loading,...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652048.2019.1620355
更新日期:2019-05-01 00:00:00
abstract::This paper discusses the optimization of the solvent evaporation process to produce double-walled (DW) microspheres in a single-step. Five process variables were studied: polymer solution concentration, polymer weight ratio, polymer solution volume ratios, encapsulation temperature, and air flow rate across the top of...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/026520499289149
更新日期:1999-03-01 00:00:00
abstract::Microcapsules containing fragrant oil (Foral oil) were synthesized via the in situ polymerization method using melamine-formaldehyde (M-F) as a wall material. The encapsulation efficiency and other physical properties were analysed with varying formaldehyde/melamine (F/M) mole ratio and pH of emulsion medium. The pH o...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652040210140472
更新日期:2002-09-01 00:00:00
abstract::A biocompatible emulsification method has been developed for microencapsulation of live cells and enzymes within a calcium alginate matrix. Fabrication of alginate beads was achieved by premixing a sequestering agent (sodium polyphosphate) and the calcium source (calcium sulphate) with the hydrogel monomer prior to th...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652049509010294
更新日期:1995-05-01 00:00:00
abstract::Clinical applications of Sesbania grandiflora bark extract (SGE) are limited because of its poor water solubility and stability. SGE was loaded in micelles of Pluronics. In vitro and in vivo antibacterial and toxicity tests were investigated using broth dilution and silkworm model. Aqueous solubility of SGE was improv...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652048.2017.1284277
更新日期:2017-02-01 00:00:00
abstract::The chitosan microspheres were prepared by a membrane emulsification method with variations of the N2 gas pressure and the chitosan concentration. The pressure of N2 gas was varied within the range from 0.2 x 10(5) to 0.8 x 10(5) Pa at chitosan concentration 1.5 wt%. In addition, the concentration of chitosan was vari...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652040410001729304
更新日期:2004-08-01 00:00:00
abstract::The effect of several parameters on the size of alginate beads produced by use of an electrostatic potential bead generator was examined. Parameters studied included needle diameter, electrostatic potential, alginate solution flow rate, gelling ion concentration and alginate concentration and viscosity, as well as alg...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652040210144234
更新日期:2002-07-01 00:00:00
abstract::Protamine-oligonucleotide nanoparticles represent effective colloidal drug carriers for antisense phosphorothioate oligonucleotides (PTO). This study describes improvements in particle preparation and the physicochemical properties of the complexes prepared. The influence of component concentrations, length of the PTO...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652040400000504
更新日期:2004-09-01 00:00:00