Abstract：
:Microspheres, including microcapsules and cells or beads, are widely used to produce many functional products. Information about their mechanical properties is essential to understanding their performance during manufacturing, processing and end-use applications. The mechanical characterization of microspheres requires applying a mechanical load onto single microspheres and measuring the corresponding deformation, and theoretical modelling of the force-deformation relationship, which allows the determination of mechanical property parameters of the materials such as the elastic modulus, yield stress or failure stress/strain. This review presents the techniques developed for the characterization of microspheres, but focus is on the two most common techniques: atomic force microscopy and compression testing by micromanipulation. The merits and limitations of these techniques and their future developments required are discussed along with the four key aspects to mechanically characterize single microspheres: (i) elastic regime, (ii) plasticity, (iii) rupture behaviour and (iv) time-dependent effects, such as viscoelasticity and permeation.
journal_name
J Microencapsuljournal_title
Journal of microencapsulationauthors
Mercadé-Prieto R,Zhang Zdoi
10.3109/02652048.2011.646331subject
Has Abstractpub_date
2012-01-01 00:00:00pages
277-85issue
3eissn
0265-2048issn
1464-5246journal_volume
29pub_type
杂志文章,评审abstract：:Chronic osteomyelitis is still the cause of many problems in orthopaedics in terms of therapy and infection persistence. Four-to-six week systemic antibiotic therapy is required along with bone and soft tissue debridement in the therapy of chronic osteomyelitis. Prolonged-release local antibiotic therapy has been take...
journal_title：Journal of microencapsulation
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abstract：:This study focuses on development and in vitro characterisation of a nasal delivery system based on uncoated or chitosan-coated solid lipid microparticles (SLMs) containing resveratrol, a natural anti-inflammatory molecule, as an effective alternative to the conventional steroidal drugs. The physico-chemical character...
journal_title：Journal of microencapsulation
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abstract：:Sequential interpenetrating networks of poly(methacrylic acid) and poly(vinyl alcohol) have been prepared and cross-linked with glutaraldehyde to obtain pH sensitive microspheres by a water-in-oil emulsification method. Microspheres have been used to deliver the chosen model anti-inflammatory drug viz., ibuprofen to t...
journal_title：Journal of microencapsulation
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abstract：:Biodegradable polymers for localized delivery of antibiotics have emerged as an important approach to treating orthopaedic infections. In chronic forms of osteomyelitis which are thought to be associated with bacterial biofilm, localized delivery of a suitable antibiotic is desirable. This paper describes the formulat...
journal_title：Journal of microencapsulation
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abstract：:We demonstrate the microencapsulation of a double-base (DB) rocket propellant stabiliser, 2-nitrodiphenylamine (2-NDPA), that can potentially increase the shelf life of DB rocket propellants. Poly(lactide-co-glycolide) (PLG) microspheres loaded with 2-NDPA were prepared using the oil-in-water emulsion technique. The m...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652048.2012.668956
更新日期：2012-01-01 00:00:00
abstract：:Clinical applications of Sesbania grandiflora bark extract (SGE) are limited because of its poor water solubility and stability. SGE was loaded in micelles of Pluronics. In vitro and in vivo antibacterial and toxicity tests were investigated using broth dilution and silkworm model. Aqueous solubility of SGE was improv...
journal_title：Journal of microencapsulation
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更新日期：2017-02-01 00:00:00
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journal_title：Journal of microencapsulation
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journal_title：Journal of microencapsulation
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journal_title：Journal of microencapsulation
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doi：10.3109/02652049809006875
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journal_title：Journal of microencapsulation
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更新日期：2011-01-01 00:00:00
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journal_title：Journal of microencapsulation
pub_type： 杂志文章,评审
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journal_title：Journal of microencapsulation
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pub_type： 杂志文章
doi：10.3109/02652049609026048
更新日期：1996-11-01 00:00:00
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journal_title：Journal of microencapsulation
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更新日期：2020-06-01 00:00:00
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journal_title：Journal of microencapsulation
pub_type： 杂志文章,评审
doi：10.3109/02652048509049572
更新日期：1985-01-01 00:00:00
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journal_title：Journal of microencapsulation
pub_type： 杂志文章
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更新日期：2000-03-01 00:00:00
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journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652048.2014.913726
更新日期：2014-01-01 00:00:00
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journal_title：Journal of microencapsulation
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更新日期：2018-01-01 00:00:00
abstract：:In ophthalmic drug delivery, a major problem is retaining an adequate concentration of a therapeutic agent in the pre-corneal area. Polycarboxylic acid carriers such as polyacrylic acid and polyitaconic acid in sub-colloidal, nanoparticulate hydrogel form have a strong potential for sustained release of a drug in ocul...
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更新日期：2004-12-01 00:00:00
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更新日期：2012-01-01 00:00:00
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journal_title：Journal of microencapsulation
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更新日期：1995-05-01 00:00:00
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journal_title：Journal of microencapsulation
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journal_title：Journal of microencapsulation
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journal_title：Journal of microencapsulation
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journal_title：Journal of microencapsulation
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更新日期：2015-01-01 00:00:00
abstract：:Ibuprofen-loaded polystyrene microparticles were prepared by the emulsion-solvent evaporation process from an aqueous system. The effects of different parameters on the drug content and on the release of the drug from the microparticles were investigated. The drug content, in all the formulations, was less than the th...
journal_title：Journal of microencapsulation
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更新日期：2000-01-01 00:00:00
abstract：:Eudragit RS microspheres containing verapamil HCl for oral use were prepared using three different dispersing agents: aluminium tristearate, magnesium stearate and sucrose stearate, by a solvent evaporation method. The effects of the type and concentration of the dispersing agents and the inner phase polymer concentra...
journal_title：Journal of microencapsulation
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更新日期：2004-03-01 00:00:00
