Abstract：
:Chronic osteomyelitis is still the cause of many problems in orthopaedics in terms of therapy and infection persistence. Four-to-six week systemic antibiotic therapy is required along with bone and soft tissue debridement in the therapy of chronic osteomyelitis. Prolonged-release local antibiotic therapy has been taken into consideration due to the side effects encountered in long-term high dose antibiotic use and the duration of hospitalization of the patients. Although local antibiotic therapy has been achieved by bone cement, a second surgical operation is needed for the removal of the system. On the other hand, heat generation during cement curing limits the use of heat-sensitive active ingredients. The most frequent osteomyelitis inducing micro-organism is gram (+) Staphylococcus aureus. In this study, teicoplanin, a glycopeptide antibiotic, active on gram (+) bacteria, was incorporated in a synthetic polymer in order to prepare a microsphere formulation for implantation to bone defects. Particle size, surface characteristics, loading capacity and in vitro release characteristics of the microspheres were determined as well as stability assessment of teicoplanin under accelerated conditions. In vivo studies were performed on rabbits and the microparticles were implanted intra-articularly to the lateral condylus of the femur. Antibiotic presence was detected by a microbiological assay from synovial fluid sample aspirated throughout 5 weeks. In the light of these evaluations, microspheres prepared from PLGA (75:25) (Mw 136,000) polymer were determined to be effective, and promising for obtaining prolonged local antibiotic release.
journal_name
J Microencapsuljournal_title
Journal of microencapsulationauthors
Yenice I,Caliş S,Atilla B,Kaş HS,Ozalp M,Ekizoğlu M,Bilgili H,Hincal AAdoi
10.1080/0265204031000154179subject
Has Abstractpub_date
2003-11-01 00:00:00pages
705-17issue
6eissn
0265-2048issn
1464-5246pii
UHH29JY145ALGTVMjournal_volume
20pub_type
杂志文章abstract：:The sustained delivery of multiple agents to the lung offers potential benefits to patients. This study explores the preparation of highly respirable dual-loaded spray-dried double emulsions. Spray-dried powders were produced from water-in-oil-in-water (w/o/w) double emulsions, containing salbutamol sulphate and/or be...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040903052044
更新日期：2010-01-01 00:00:00
abstract：:Polylactic acid microcapsules containing randomly distributed hydrocortisone particles were prepared. The rate of release of hydrocortisone from the microcapsules in pH 7.4 phosphate buffer was found to be largely increased by the presence of polysorbate 80, cetylpyridinium chloride, or aerosol OT in the dissolution m...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652048809036721
更新日期：1988-01-01 00:00:00
abstract：:The influence of drug particle size on the production of enteric beads by a polymer precipitation technique was investigated. Drug particle dimensions are known to play an important role in most microencapsulation techniques. Bead morphology was greatly influenced by drug particle size, and spherical shaped beads coul...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040050161729
更新日期：2000-11-01 00:00:00
abstract：:The regularities of release of therapeutic antioxidant enzyme superoxide dismutase (SOD) from various alginate-based delivery systems (DS) into simulated gastric and intestinal fluids were determined. The following systems were used: Ca-alginate granules (AG) prepared by various methods, porous carbonate cores with mu...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652048.2016.1206146
更新日期：2016-08-01 00:00:00
abstract：:Nanoencapsulation by spray drying was performed to protect and preserve antioxidant rich dietary polyphenols from green coffee beans. Nano-encapsulation of green coffee was done using maltodextrin as wall material. The nanoparticles were further characterised by zetasizer, differential scanning colorimetry, X-ray diff...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652048.2019.1692946
更新日期：2020-01-01 00:00:00
abstract：:Low molecular weight heparin (LMWH)-loaded flexible liposomes (flexosomes) were formulated for transdermal delivery, and their physicochemical and pharmacokinetic parameters were compared with LMWH-loaded ethosomes. Flexosomes had similar particle size compared with ethosomes, but their deformability was higher than t...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652048.2010.507880
更新日期：2011-01-01 00:00:00
abstract：:Abietic acid was isolated from rosin N Grade (ISI) by a simple process and the product was further standardized. Sulphadiazine microcapsules were prepared by the solvent evaporation technique, using abietic acid as a wall-forming material. Discrete, spherical and free-flowing microcapsules were obtained by phase separ...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652049209040481
更新日期：1992-10-01 00:00:00
abstract：PURPOSE:To develop a stable and reproducible modified release pellet formulation containing ibuprofen. METHODS:Using extrusion-spheronization technology to produce pellets. RESULTS:The percentage yield, size distribution and overall pellet shape within the desired size range of 1000-1400 microm was found to be depend...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040500162535
更新日期：2005-09-01 00:00:00
abstract：:Radioembolization is used in diagnostic imaging of the lungs and for radioembolization therapy of hepatic tumours. Presently, 99mTc labelled macroaggregates or microspheres of human serum albumin (HAM) are used for this purpose. Poly lactic acid (PLA) is biodegradable, like HAM, and, unlike HAM, is not a blood product...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/026520400405750
更新日期：2000-07-01 00:00:00
abstract：:Grapes (Vitis vinifera) are produced in large amounts worldwide and mostly are used for winemaking. Their untreated wastes are rich in valuable secondary metabolites, such as phenolics. Thus, in this study, white and red wine wastes (Malagouzia and Syrah variety) were investigated for their added value phenolics, whic...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652048.2018.1462415
更新日期：2018-05-01 00:00:00
abstract：:This work demonstrates Box-Behnken design (BBD)'s capability in exploring scientific principles governing a process, different from its use in process optimisation. We have investigated nanoprecipitation (NP) of temozolomide with polycaprolactone. Five factors, surfactant, stirring speed (SS), dropping rate (DR), phas...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652048.2014.950710
更新日期：2015-01-01 00:00:00
abstract：:Using formalin inactivated Actinobacillus pleuropneumoniae antigens and aqueous ethylcellulose dispersions, microspheres of oral vaccines were developed by a co-spray drying process. The present study attempted to determine whether the dosage formulations of microspheres could form enteric matrices. To assess the ente...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040010019442
更新日期：2001-05-01 00:00:00
abstract：:The objective of this study was selection of most influential variable for the preparation of gastro adhesive nanoparticles of acyclovir. Effect of formulation and processing variables on various response variables were studied by a Taguchi standard orthogonal array L8 design. Independent variables studied were the am...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652048.2013.863398
更新日期：2014-01-01 00:00:00
abstract：:A combined approach based on drug cyclodextrin (CD) complexation and loading into PLGA nanoparticles (NP) has been developed to improve oxaprozin therapeutic efficiency. This strategy exploits the solubilizing and stabilizing properties of CDs and the prolonged-release and targeting properties of PLGA NPs. Drug-loaded...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652040903515508
更新日期：2010-01-01 00:00:00
abstract：:Captopril microcapsules were prepared using four different viscosity grades of ethyl cellulose (core: wall ratios 1:1, 1:2 and 1:3) by temperature induced coacervation from cyclohexane. In vitro dissolution studies in 0.1 M hydrochloric acid showed that the drug release was dependent on the core to wall ratio, the vis...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652049009028424
更新日期：1990-01-01 00:00:00
abstract：AIM:This study aimed to evaluate the protective effect of flaxseed mucilage on the co-extrusion microencapsulation of Lactobacillus rhamnosus GG. METHODS:Core flow rate, chitosan coating, and flaxseed mucilage concentration were optimised for the microencapsulation of L. rhamnosus. The microbeads were characterised an...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652048.2020.1863490
更新日期：2020-12-28 00:00:00
abstract：:Indomethacin-loaded dietheylaminoethyl trisacryl microspheres (DEAE-MS), originally designed for therapeutic embolization, were encapsulated using two methods: coacervation and solvent evaporation/extraction. This encapsulation was achieved using a biocompatible polymer, the PLGA 50 : 50, and aimed to control the rele...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040701843388
更新日期：2008-03-01 00:00:00
abstract：:A biocompatible emulsification method has been developed for microencapsulation of live cells and enzymes within a calcium alginate matrix. Fabrication of alginate beads was achieved by premixing a sequestering agent (sodium polyphosphate) and the calcium source (calcium sulphate) with the hydrogel monomer prior to th...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652049509010294
更新日期：1995-05-01 00:00:00
abstract：PURPOSE:Naproxen CR tablets have been obtained from its microspheres prepared by coprecipitation with Eudragit L100-55. The purpose of this work was to evaluate the main and interaction effects of deaggregating agent concentration (X1), compression pressure (X2) and amount of precipitating water (X3) on naproxen releas...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040110055630
更新日期：2001-09-01 00:00:00
abstract：:H-n.m.r. spectroscopy of small unilamellar phospholipid vesicles in the presence of the lanthanide probe ion Dy3+ has been used to study the permeability of these liposomes induced by the bile salts (glycocholate and glycodeoxycholate) and pancreatic phospholipase A2. A marked synergism is demonstrated in the combined...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652048409038515
更新日期：1984-04-01 00:00:00
abstract：:The mechanism by which microcapsule aggregation is diminished in the presence of low concentrations of adjunct non-walling polymers such as polyisobutylene (PIB) in organic solvents is uncertain. It is here investigated by phase separation studies employing the non-solvent addition method (cyclohexane) in parallel wit...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652049009028419
更新日期：1990-01-01 00:00:00
abstract：:This study explored a liquid phase coating technique to produce polymethyl methacrylate (PMMA)-coated alginate microspheres. Alginate microspheres with a mean diameter of 85.6 microm were prepared using an emulsification method. The alginate microspheres, as cores, were then coated with different types of PMMA by a li...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040500273936
更新日期：2005-12-01 00:00:00
abstract：:A considerable effort has been spent in the past three decades to investigate various aspects of liposomes as novel drug delivery systems. In 1990, the first amphotericin B (AmB) liposomal preparation (L-AmB) under the brand name AmBisome was introduced into the market by Vestar. The successful marketing of the produc...
journal_title：Journal of microencapsulation
pub_type： 杂志文章,评审
doi：10.3109/02652049809006844
更新日期：1998-03-01 00:00:00
abstract：:This study aims to formulate a microparticle-based system that protects the protein from the harsh gastric conditions and also provides appropriate uptake via M cells for desired immune response upon oral administration. The formulation was derived using a valid statistical model, analysed by JMP® (SAS). The average s...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652048.2011.651503
更新日期：2012-01-01 00:00:00
abstract：:In this study microspheres of diclofenac sodium, an anti-inflammatory agent, were prepared by utilizing a natural polysaccharide, chitosan-H. The objective of this investigation was to sustain the action of diclofenac sodium and to show the effect of various conditions on release kinetics. For this reason factorial de...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652049609052903
更新日期：1996-03-01 00:00:00
abstract：:The blood-brain barrier (BBB) is the major problem for the treatment of central nervous system diseases. A previous study from our group showed that the brain-targeted chitosan nanoparticles-loaded with large peptide moieties can rapidly cross the barrier and provide neuroprotection. The present study aims to determin...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652048.2017.1375039
更新日期：2017-11-01 00:00:00
abstract：:This work investigated the means for the efficient encapsulation of muramyl dipeptide (MDP) in poly(epsilon-caprolactone) (PCL) microparticles (MP) by a solvent evaporation method in order to optimize the effect of the adjuvant for oral immunization. Therefore, the influence of MDP concentration in the inner aqueous p...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/026520499288799
更新日期：1999-09-01 00:00:00
abstract：AIM:To study the effect of poly(d,l-lactic-co-glycolic acid) (PLGA) microparticles (MPs) preparation techniques on particle physical characterization with special emphasis on burst drug release. METHODS:A basic drug clozapine was used in combination with acid-terminated PLGA. Two approaches for MP preparation were com...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652048.2014.913724
更新日期：2014-01-01 00:00:00
abstract：:Nanoparticles prepared of human serum albumin (HSA) represent promising carriers for drug delivery. Desolvating procedure is a common method to obtain protein-based particles. However process parameters have a great influence on size, size distribution and particle yield of the resulting formulation. Therefore, it is ...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652048.2011.635218
更新日期：2012-01-01 00:00:00
abstract：:Aim: A novel folated pluronic F127 (FA-F127) was synthesised, so as to modify liposomes with FA group on the surface, and evaluate the effects of FA-F127 modification on the properties of the modified liposomes.Methods: FA was linked to one end of pluronic F127, via the terminal OH group, to obtain FA-F127 and the str...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652048.2020.1720030
更新日期：2020-05-01 00:00:00
