Chitosan-xanthan gum microparticle-based oral tablet for colon-targeted and sustained delivery of quercetin.

Abstract:

CONTEXT:Quercetin (QUE) is a flavonoid with antioxidant/anti-inflammatory properties, poorly absorbed when orally administered. OBJECTIVES:To prepare chitosan/xanthan gum microparticles to increase QUE oral bioavailability and optimize its release in the colon. MATERIALS AND METHODS:Chitosan/xanthan gum hydrogel embedding QUE was spray-dried to obtain microparticles characterized by size, scanning electron microscopy, differential scanning calorimetry and X-ray diffraction. Microparticles were compressed into tablets, coated with Eudragit® to further prevent degradation in acidic pH. The swelling degree and QUE release in simulated gastric and intestinal pH were investigated. RESULTS:Microparticles were smooth and spherical, around 5 µm, with successful QUE loading. Microparticle tablets provided resistance to acidic conditions, allowing complete drug release in alkaline pH, mimicking colonic environment. The release was controlled by non-Fickian diffusion of the dissolved drug out of the swollen polymeric tablet. DISCUSSION AND CONCLUSION:Microparticle tablets represent a promising dosage form for QUE delivery to the colon in the oral therapy of inflammatory-based disorders.

journal_name

J Microencapsul

authors

Caddeo C,Nácher A,Díez-Sales O,Merino-Sanjuán M,Fadda AM,Manconi M

doi

10.3109/02652048.2014.913726

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

694-9

issue

7

eissn

0265-2048

issn

1464-5246

journal_volume

31

pub_type

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