Abstract:
:A biocompatible emulsification method has been developed for microencapsulation of live cells and enzymes within a calcium alginate matrix. Fabrication of alginate beads was achieved by premixing a sequestering agent (sodium polyphosphate) and the calcium source (calcium sulphate) with the hydrogel monomer prior to the introduction to the oil phase. The competition between the sequesterant and sodium alginate in binding the available calcium ions results in a slowing down of the rate of polymerization and thereby lead to a successful calcium alginate bead formation. The mean diameter of the fabricated beads may be easily controlled by employing soy bean lecithin as an emulsifier. The polymerization time in this process may vary between 3 and 35 min depending on the ratio of sequesterant to that of calcium source at constant sodium alginate concentration. This preparation method avoids the use of pH extremes at all times and therefore is particularly suitable for encapsulating pH-sensitive cells and enzymes.
journal_name
J Microencapsuljournal_title
Journal of microencapsulationauthors
Monshipouri M,Price RRdoi
10.3109/02652049509010294subject
Has Abstractpub_date
1995-05-01 00:00:00pages
255-62issue
3eissn
0265-2048issn
1464-5246journal_volume
12pub_type
杂志文章abstract::The diblock copolymers based on PBLG and PEO (GE) were synthesized and characterized. Nanoparticles showed spherical shape from the observations of TEM and approved core-shell structure. Drug contents were increased with use of higher initial drug concentration and higher Mw of GE. Nifedipine (NFD) release rate was sl...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652040410001729241
更新日期:2004-06-01 00:00:00
abstract::The purpose of present research work was to develop mucoadhesive microspheres for nasal delivery with the aim to avoid hepatic first-pass metabolism, improve therapeutic efficacy and enhance residence time. For the treatment of migraine, hydroxypropyl methylcellulose (HPMC) K4M and K15M based microspheres containing s...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652040802685241
更新日期:2009-12-01 00:00:00
abstract::For slow release of tea tree oil (TTO), TTO were encapsulated by urea-formaldehyde (UF) resin via in situ polymerisation. The effects of curing time and drying condition on particle size, and TTO loading of the TTO/UF microcapsules were investigated. The results indicated that TTO/UF resin microcapsules with curing ti...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652048.2020.1735548
更新日期:2020-06-01 00:00:00
abstract::Background: Lavender oil consists of around 100 components and is susceptible to volatilisation and degradation reactions. Aim: Microencapsulate lavender oil by spray drying using a biocompatible polymeric blend of gum acacia and maltodextrin to protect the oil components. Effect of total polymer content, oil loading,...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652048.2019.1620355
更新日期:2019-05-01 00:00:00
abstract::Graft copolymer polyethylenimine-graft-poly(N-vinylpyrrolidone) (PEI-g-PVP) was prepared by coupling mono carboxyl-terminated PVP (PVP-COOH) with PEI using N,N'-dicyclohexylcarbodiimide (DCC) and N-hydroxysuccinimide (NHS) as coupling agents. In aqueous medium, PVP-g-PEI can self-assemble into stable polyion complex m...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652048.2010.534823
更新日期:2011-01-01 00:00:00
abstract::The present study describes the development of a new cyclosporine formulation based on polycaprolactone (PCL) microspheres (MS) prepared by the solvent evaporation method. Ternary phase diagrams were used to identify the domains where MS were formed. The application of central composite designs established the influen...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652040110055270
更新日期:2002-01-01 00:00:00
abstract::Proliposomes of ibuprofen were successfully prepared using effervescent granules as solid carriers of dried phospholipids along with other lipids (soyabean lecithin, stearylamine and cholesterol). Liposomes of regular size with uniform size distribution resulted when proliposomal formulations were hydrated under the e...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652049009040467
更新日期:1990-10-01 00:00:00
abstract::The present study is part of a larger project whose aim is to understand how the oyster Crassostrea gigas develops its aromas from a lipid precursor, the eicosapentaenoic acid (EPA), in glyceride form. The objective of this study is, therefore, to prepare an encapsulation process that will enable the bivalve to be sup...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:
更新日期:2003-01-01 00:00:00
abstract::Drug-free polylactic acid (PLA) microspheres were prepared by an emulsification-solvent evaporation technique using different types of protective colloids. The influence of five types of hydrophilic prolymers (polysaccharides, proteins, synthetic cellulose derivatives, synthetic nonionic polymers and surfactants) on t...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652049809006865
更新日期:1998-05-01 00:00:00
abstract:CONTEXT:Solid lipid nanoparticles (SLNs) can efficiently and efficaciously incorporate anti-cancer agents. OBJECTIVE:To prepare and characterise tamoxifen (TAM)-loaded SLNs. MATERIALS AND METHODS:Glyceryl monostearate, Tween-80, and trehalose were used in SLNs. SLNs were tested via dynamic light scattering (DLS), tra...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652048.2014.898707
更新日期:2014-01-01 00:00:00
abstract::The mechanism by which microcapsule aggregation is diminished in the presence of low concentrations of adjunct non-walling polymers such as polyisobutylene (PIB) in organic solvents is uncertain. It is here investigated by phase separation studies employing the non-solvent addition method (cyclohexane) in parallel wit...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652049009028419
更新日期:1990-01-01 00:00:00
abstract::The purpose of this study was the preparation, optimisation and in vitro characterisation of PHBV and PLGA blend nanoparticles (NPs) for prolonged delivery of Teriparatide. Double emulsion solvent evaporation technique was employed for the fabrication of NPs. The nanoformulation was optimised using the Box-Behnken met...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652048.2016.1208296
更新日期:2016-08-01 00:00:00
abstract::Freeze-drying is an effective way to improve long-term physical stability of nanosuspension in drug delivery applications. Nanosuspension also known as suspension of nanoparticles. In this study, the effect of freeze-drying with different cryoprotectants on the physicochemical characteristics of resveratrol (RSV) nano...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652048.2018.1462416
更新日期:2018-05-01 00:00:00
abstract::Catechin (CT) is natural molecule proved for antidiabetic activity. Clinical application of CT is highly restricted because of its low bioavailability and ineffectiveness in in vivo conditions. Therefore, the main objective of the present investigation was to formulate CT-loaded Eudragit RS 100 microparticles and eval...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652048.2017.1337248
更新日期:2017-06-01 00:00:00
abstract::This study focuses on development and in vitro characterisation of a nasal delivery system based on uncoated or chitosan-coated solid lipid microparticles (SLMs) containing resveratrol, a natural anti-inflammatory molecule, as an effective alternative to the conventional steroidal drugs. The physico-chemical character...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652048.2016.1260659
更新日期:2016-12-01 00:00:00
abstract::Emulsions of menhaden oil and sodium caseinate (NaCas) incorporating carbohydrates of varying dextrose equivalence (DE) were spray-dried to yield encapsulated fish oil powders. The effects of carbohydrate DE (5.5-38), core/wall ratio and NaCas/carbohydrate ratio on microencapsulation efficiency (ME) and oxidative stab...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/0265204031000151974
更新日期:2003-09-01 00:00:00
abstract::Redox-responsive magnetic protein microcapsules with Fe3O4 magnetic nanoparticles (MNPs) encapsulated inside have been obtained using a facile, cost-effective and fast sonochemical method from hen egg white proteins. Such prepared redox-responsive magnetic hen egg white protein microcapsules (MHEWPMCs) could be easily...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652048.2015.1073389
更新日期:2015-01-01 00:00:00
abstract::D,L-polylactic acid (PLA) microspheres containing quinidine base and quinidine sulphate were prepared by the solvent evaporation method. The present study was carried out to examine how various process parameters in the aqueous phase influenced the preparation and properties of PLA-microspheres. The amount of drug tha...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652048709021821
更新日期:1987-10-01 00:00:00
abstract::Isoniazid was encapsulated into microspheres of alginate-chitosan by means of a complex coacervation method in an emulsion system. Since the encapsulation of isoniazid tends to be limited by its hydrophilic characteristics, this study proposes its microencapsulation by adsorption. The particles were prepared in three ...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:
更新日期:2003-03-01 00:00:00
abstract::Solid lipid nanoparticles (SLNs) and nanosuspensions (NSs) have shown great promise for improving bioavailability of poorly water-soluble drugs. This study was aimed to develop SLNs and NS of Saquinavir (SQ) for improvement in bioavailability. These formulations were characterized and their pharmacokinetics and biodis...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652048.2011.590612
更新日期:2011-01-01 00:00:00
abstract:PURPOSE:This investigation was undertaken to develop glyceryl monostearate (Geleol)-based solid lipid nanoparticles (SLNs) of a hydrophilic drug ciprofloxacin HCl. METHODS:Hansen's solubility parameter study was carried out in screening of a suitable carrier and solvent system. Subsequently, SLNs were prepared by solv...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652048.2011.651498
更新日期:2012-01-01 00:00:00
abstract::Clinical applications of Sesbania grandiflora bark extract (SGE) are limited because of its poor water solubility and stability. SGE was loaded in micelles of Pluronics. In vitro and in vivo antibacterial and toxicity tests were investigated using broth dilution and silkworm model. Aqueous solubility of SGE was improv...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652048.2017.1284277
更新日期:2017-02-01 00:00:00
abstract::The development of microparticulate food particles for marine suspension-feeders is discussed with respect to the difficulties of nutrient delivery in the aquatic environment and to feeding and digestion in crustacea and bivalve molluscs. Loss of nutrients from particles suspended in seawater must be minimized by eith...
journal_title:Journal of microencapsulation
pub_type: 杂志文章,评审
doi:10.3109/02652048509049572
更新日期:1985-01-01 00:00:00
abstract::Silica gel microspheres are ideal materials for bioencapsulation due to their mechanical properties, biocompatibility, and stability. Encapsulated cells are isolated from the environment and protected from predators, changes in pH, and osmotic stress. However methods for the production of silica gel microspheres suita...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652048.2016.1202346
更新日期:2016-08-01 00:00:00
abstract::Haemoglobin (Hb) was encapsulated into liposomes as a blood substitute by a freeze-thaw method. The encapsulation efficiency was affected by the Hb/lipid ratio, starting Hb concentration, pH and salt concentration. Liposome-encapsulated haemoglobin (LEH) prepared by this method contains 5-10 mM Hb with 4-10 per cent m...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652049409034258
更新日期:1994-07-01 00:00:00
abstract::A combined approach based on drug cyclodextrin (CD) complexation and loading into PLGA nanoparticles (NP) has been developed to improve oxaprozin therapeutic efficiency. This strategy exploits the solubilizing and stabilizing properties of CDs and the prolonged-release and targeting properties of PLGA NPs. Drug-loaded...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652040903515508
更新日期:2010-01-01 00:00:00
abstract::Liposomes containing Isovist were prepared by controlled detergent dialysis as well as by reverse phase evaporation. After preparation these liposomes were lyophilized and then submitted to sterilization by ethylene oxide. Prior to lyophilization, trehalose was added as a protective agent to preserve the size of the l...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652048909031168
更新日期:1989-10-01 00:00:00
abstract::The degradation of polybutylcyanoacrylate (PBC) and polyhexylcyanoacrylate (PHC) nanoparticles, together with their association with and toxicity towards isolated hepatocytes, were determined. Nanoparticles were not taken up by rat hepatocytes at a significant level. The LD50S of PBC and PHC nanoparticles towards hepa...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652048409049364
更新日期:1984-07-01 00:00:00
abstract::Using liposomes radiolabelled by the 99mTechnetium-stannous chloride technique we have investigated the effect of surface charge on the stability of the isotope in vitro and in vivo. Dialysis of 99mTc-labelled positive, negative and neutral liposomes, which had been incubated in either saline or normal rat serum showe...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652048909019907
更新日期:1989-01-01 00:00:00
abstract::The aim of this study was to develop and characterize diclofenac sodium loaded-cellulose acetate butyrate microparticles in order to obtain a controlled-release system. The influence of the type of polymer, the volume and composition of the internal phase, drug loading, surfactant concentration and additive added on m...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652040701747928
更新日期:2008-02-01 00:00:00