Abstract:
PURPOSE:This investigation was undertaken to develop glyceryl monostearate (Geleol)-based solid lipid nanoparticles (SLNs) of a hydrophilic drug ciprofloxacin HCl. METHODS:Hansen's solubility parameter study was carried out in screening of a suitable carrier and solvent system. Subsequently, SLNs were prepared by solvent diffusion evaporation method and investigated for particle size, polydispersity index (PDI), zeta potential (ZP), entrapment efficiency (EE) and drug release behaviour. RESULTS:Variations in SLN composition resulted in particle sizes between 170 and 810 nm and ZPs between 8 and 14 mV. The maximum EE was found to be 26.3% with particle size of 188.8 nm. SLN can sustain the release of drug for up to 15 h and it shows Higuchi matrix model as the best-fitted model. SLNs were stable without aggregation of particles under storage conditions. CONCLUSIONS:The results of this study provide the framework for further study involving the SLN formulation for hydrophilic drug molecule.
journal_name
J Microencapsuljournal_title
Journal of microencapsulationauthors
Shah M,Agrawal Ydoi
10.3109/02652048.2011.651498subject
Has Abstractpub_date
2012-01-01 00:00:00pages
331-43issue
4eissn
0265-2048issn
1464-5246journal_volume
29pub_type
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journal_title:Journal of microencapsulation
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journal_title:Journal of microencapsulation
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journal_title:Journal of microencapsulation
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更新日期:1993-01-01 00:00:00
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journal_title:Journal of microencapsulation
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journal_title:Journal of microencapsulation
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更新日期:2007-12-01 00:00:00
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