Polycarboxylic acid nanoparticles for ophthalmic drug delivery: an ex vivo evaluation with human cornea.


:In ophthalmic drug delivery, a major problem is retaining an adequate concentration of a therapeutic agent in the pre-corneal area. Polycarboxylic acid carriers such as polyacrylic acid and polyitaconic acid in sub-colloidal, nanoparticulate hydrogel form have a strong potential for sustained release of a drug in ocular delivery. Formulations have been prepared of brimonidine loaded in polycarboxylic (polyacrylic and polyitaconic) acid nanoparticles for potential ophthalmic delivery. These particles were prepared by a reverse micro-emulsion polymerization technique with sizes in the range of 50 nm. The loading efficiencies of the drug brimonidine in the particles were shown to be between 80-85% for polyacrylic acid nanoparticles and between 65-70% for polyitaconic nanoparticles. The loading efficiency was also found to be pH dependent. In a preliminary biocompatibility test, human corneal epithelial cells incubated with polyacrylic acid nanoparticles were found to retain their viability, whereas polyitaconic acid nanoparticles were found to be toxic. Two-photon laser scanning microscopic studies of the fluorescently labelled polyacrylic acid nanoparticles and human cornea shows that they are adhesive on the corneal surface. The polyacrylic acid nanoparticles demonstrated a controlled release of the opthalmological drug (Brimonidine) through the human cornea as compared to that of the commercial formulation, Alphagan.


J Microencapsul


De TK,Bergey EJ,Chung SJ,Rodman DJ,Bharali DJ,Prasad PN




Has Abstract


2004-12-01 00:00:00












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    abstract::Biodegradable polymers for localized delivery of antibiotics have emerged as an important approach to treating orthopaedic infections. In chronic forms of osteomyelitis which are thought to be associated with bacterial biofilm, localized delivery of a suitable antibiotic is desirable. This paper describes the formulat...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Habib M,Onyilofor S,Ebube NK,Owusu-Ababio G

    更新日期:1999-01-01 00:00:00

  • Quality improvement of spray-dried, protein-loaded D,L-PLA microspheres by appropriate polymer solvent selection.

    abstract::The aim was to study the effect of the type of polymer solvent on characteristics of microspheres produced by spray drying. The water-soluble model protein, bovine serum albumin (BSA) was microencapsulated into biodegradable poly(D,L-lactic acid) using the following 10 different polymer solvents: acetaldehyde dimethyl...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Gander B,Wehrli E,Alder R,Merkle HP

    更新日期:1995-01-01 00:00:00

  • Microencapsulation of alpha-mangostin into PLGA microspheres and optimization using response surface methodology intended for pulmonary delivery.

    abstract::Documented to exhibit cytotoxicity and poor oral bioavailability, alpha-mangostin was encapsulated into PLGA microspheres with optimization of formulation using response surface methodology. Mixed levels of four factors Face central composite design was employed to evaluate critical formulation variables. With 30 runs...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Elsaid Ali AA,Taher M,Mohamed F

    更新日期:2013-01-01 00:00:00

  • Liposomes incorporating essential oil of Brazilian cherry (Eugenia uniflora L.): characterization of aqueous dispersions and lyophilized formulations.

    abstract::Multilamellar liposomes incorporating essential oil of Brazilian cherry (Eugenia uniflora L.) leaves were produced by dry film hydration. Gas chromatography demonstrated the compounds found in the essential oil were effectively incorporated in the aqueous dispersions of liposomes. Differential scanning calorimetry ana...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Yoshida PA,Yokota D,Foglio MA,Rodrigues RA,Pinho SC

    更新日期:2010-01-01 00:00:00

  • Monitoring by cis-parinaric fluorescence of free radical induced lipid peroxidation in aqueous liposome suspensions.

    abstract::Cis-parinaric acid is fluorescent when partioned into a lipid environment and its fluorescence is destroyed upon reaction with free radicals. In our study 1-palmitoyl-2-parinoyl-phosphatidylcholine (cis-PnA) has been used to monitor the time-course of liposomal lipid peroxidation, using reverse-phase evaporation vesic...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Di Giulio A,Saletti A,Oratore A,Bozzi A

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  • Synthesis and characterisation of chitosan-encapsulated genistein: its anti-proliferative and anti-angiogenic activities.

    abstract::Aims: The study was carried out to synthesise and characterise the chitosan-encapsulated genistein (CHI-En/Gen) and determine its anti-cancer and anti-angiogenic properties.Methods: The cytotoxic and anti-angiogenic activity of CHI-En/Gen was performed using MTT and chorioallantoic membrane assay. The molecular action...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Rahmani F,Karimi E,Oskoueian E

    更新日期:2020-06-01 00:00:00

  • Release characteristics of microspheres prepared by co-spray drying Actinobacillus pleuropneumoniae antigens and aqueous ethyl-cellulose dispersion.

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    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Liao CW,Cheng IC,Yeh KS,Lin FY,Weng CN

    更新日期:2001-05-01 00:00:00

  • Hyaluronidase-injectable microparticles intended for the treatment of extravasation.

    abstract::Hyaluronidase is a protein whose enzymatic activity is successfully employed in extravasation therapy. Taking into account that several proteins (e.g. gelatin and albumin) have been employed as natural polymers for the preparation of microspheres, this work approaches a comprehensive investigation on hyaluronidase inj...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Modena T,Conti B,Genta I,Pauanetto F,Tira ME,Sini P,Gazzaniga A

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  • Preparation of chitosan microspheres using membrane emulsification and its size modelling.

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    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Park SB,Jeon YJ,Haam S,Park HY,Kim WS

    更新日期:2004-08-01 00:00:00

  • In vitro/in vivo evaluation of the efficiency of teicoplanin-loaded biodegradable microparticles formulated for implantation to infected bone defects.

    abstract::Chronic osteomyelitis is still the cause of many problems in orthopaedics in terms of therapy and infection persistence. Four-to-six week systemic antibiotic therapy is required along with bone and soft tissue debridement in the therapy of chronic osteomyelitis. Prolonged-release local antibiotic therapy has been take...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Yenice I,Caliş S,Atilla B,Kaş HS,Ozalp M,Ekizoğlu M,Bilgili H,Hincal AA

    更新日期:2003-11-01 00:00:00

  • Transdermal delivery of low molecular weight heparin loaded in flexible liposomes with bioavailability enhancement: comparison with ethosomes.

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    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Song YK,Hyun SY,Kim HT,Kim CK,Oh JM

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  • Effect of common classes of excipients on extrusion-spheronization.

    abstract::Different classes of excipients with potential for use in the design of novel pelletized formulations manufactured by extrusion-spheronization were examined using factorial experiments. Among the various silicates examined in a model mix with microcrystalline cellulose and lactose wetted with water, kaolin, talc and V...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Law MF,Deasy PB

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    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Zimmer A,Kreuter J,Robinson JR

    更新日期:1991-10-01 00:00:00

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    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Anantaworasakul P,Okonogi S

    更新日期:2017-02-01 00:00:00

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    pub_type: 杂志文章


    authors: Vandelli MA,Fresta M,Puglisi G,Forni F

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    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Vuaridel-Bonanomi ES,Weder HG

    更新日期:1991-04-01 00:00:00

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    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Wang DW,Zhao XP

    更新日期:2009-02-01 00:00:00

  • Preparation and characterization of calcium-shellac spheres as a carrier of carbamide peroxide.

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    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Xue J,Zhang Z

    更新日期:2008-12-01 00:00:00

  • Toxicity and association of polycyanoacrylate nanoparticles with hepatocytes.

    abstract::The degradation of polybutylcyanoacrylate (PBC) and polyhexylcyanoacrylate (PHC) nanoparticles, together with their association with and toxicity towards isolated hepatocytes, were determined. Nanoparticles were not taken up by rat hepatocytes at a significant level. The LD50S of PBC and PHC nanoparticles towards hepa...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Kreuter J,Wilson CG,Fry JR,Paterson P,Ratcliffe JH

    更新日期:1984-07-01 00:00:00

  • Preparation of polyurea/melamine formaldehyde double-layered self-healing microcapsules and investigation on core fraction.

    abstract::Moisture curing type self-healing microcapsules become more attractive, while instability of active core material crippled the efficiency of self-healing behaviour. Polyurea (PU)/melamine formaldehyde (MF) double-layered self-healing microcapsules containing isophorone diisocyanate (IPDI) core with high and stable cor...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Ming Y,Hu J,Xing J,Wu M,Qu J

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  • 99mTc-labelled monodisperse latex particles coated with amino or carboxyl groups for studies of GI function.

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    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Ercan MT,Tuncel SA,Caner BE,Pişkin E

    更新日期:1993-01-01 00:00:00

  • Effect of different dispersing agents on the characteristics of Eudragit microspheres prepared by a solvent evaporation method.

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    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Horoz BB,Kiliçarslan M,Yüksel N,Baykara T

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  • Development of a continuous reactor for emulsion-based microencapsulation of hexyl acetate with a polyuria shell.

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    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Gobert SRL,Segers M,Luca S,Teixeira RFA,Kuhn S,Braeken L,Thomassen LCJ

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  • Microencapsulation of Clostridium acetobutylicum ATCC 824 spores in gellan gum microspheres for the production of biobutanol.

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    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Rathore S,Wan Sia Heng P,Chan LW

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  • A novel microparticulate vaccine for melanoma cancer using transdermal delivery.

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    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Bhowmik T,D'Souza B,Shashidharamurthy R,Oettinger C,Selvaraj P,D'Souza MJ

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  • Delivery of rSLPI in a liposomal carrier for inhalation provides protection against cathepsin L degradation.

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    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Gibbons AM,McElvaney NG,Taggart CC,Cryan SA

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    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Li Y,Zhou Y,De B,Li L

    更新日期:2014-01-01 00:00:00

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    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Ertan G,Karasulu E,Abou-Nada M,Tosun M,Ozer A

    更新日期:1994-03-01 00:00:00

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    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Klokk TI,Melvik JE

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    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Sawaya A,Fickat R,Benoit JP,Puisieux F,Benita S

    更新日期:1988-07-01 00:00:00