Abstract：
:In ophthalmic drug delivery, a major problem is retaining an adequate concentration of a therapeutic agent in the pre-corneal area. Polycarboxylic acid carriers such as polyacrylic acid and polyitaconic acid in sub-colloidal, nanoparticulate hydrogel form have a strong potential for sustained release of a drug in ocular delivery. Formulations have been prepared of brimonidine loaded in polycarboxylic (polyacrylic and polyitaconic) acid nanoparticles for potential ophthalmic delivery. These particles were prepared by a reverse micro-emulsion polymerization technique with sizes in the range of 50 nm. The loading efficiencies of the drug brimonidine in the particles were shown to be between 80-85% for polyacrylic acid nanoparticles and between 65-70% for polyitaconic nanoparticles. The loading efficiency was also found to be pH dependent. In a preliminary biocompatibility test, human corneal epithelial cells incubated with polyacrylic acid nanoparticles were found to retain their viability, whereas polyitaconic acid nanoparticles were found to be toxic. Two-photon laser scanning microscopic studies of the fluorescently labelled polyacrylic acid nanoparticles and human cornea shows that they are adhesive on the corneal surface. The polyacrylic acid nanoparticles demonstrated a controlled release of the opthalmological drug (Brimonidine) through the human cornea as compared to that of the commercial formulation, Alphagan.
journal_name
J Microencapsuljournal_title
Journal of microencapsulationauthors
De TK,Bergey EJ,Chung SJ,Rodman DJ,Bharali DJ,Prasad PNdoi
10.1080/02652040400008515subject
Has Abstractpub_date
2004-12-01 00:00:00pages
841-55issue
8eissn
0265-2048issn
1464-5246journal_volume
21pub_type
杂志文章abstract：:For the preparation of microcapsules using the W/O/W (water in oil in water) emulsion system, it is essential to control various factors such as the dispersed state of the organic phase in the W/O/W emulsion, the difference in the solute concentration between the inner and outer aqueous phases and the volume fraction ...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/0265204031000093096
更新日期：2003-07-01 00:00:00
abstract：PURPOSE:To develop a stable and reproducible modified release pellet formulation containing ibuprofen. METHODS:Using extrusion-spheronization technology to produce pellets. RESULTS:The percentage yield, size distribution and overall pellet shape within the desired size range of 1000-1400 microm was found to be depend...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040500162535
更新日期：2005-09-01 00:00:00
abstract：:The diblock copolymers based on PBLG and PEO (GE) were synthesized and characterized. Nanoparticles showed spherical shape from the observations of TEM and approved core-shell structure. Drug contents were increased with use of higher initial drug concentration and higher Mw of GE. Nifedipine (NFD) release rate was sl...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040410001729241
更新日期：2004-06-01 00:00:00
abstract：:To improve poor water solubility of cyclosporine A (CsA), hydroxypropyl-beta-cyclodextrin (HPβCD) was incorporated into the nanoparticle formulation. Solid complexes of CsA with HPβCD in different ratios were prepared by the kneading method. CsA containing alone or in combination with HPβCD in poly-lactide-co-glycolid...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652048.2012.668961
更新日期：2012-01-01 00:00:00
abstract：:Poly-D,L-lactide (PDLLA) and polylactide-co-glycolide (PLGA) microspheres containing thymopentin have been prepared by a water-in-oil-in-water-emulsion/solvent evaporation technique. The goal is to stabilize the active compound thymopentin, and to prolong its therapeutic activity, by embedding the drug in a polymeric ...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652049709051134
更新日期：1997-05-01 00:00:00
abstract：:Monodisperse Ca-alginate microspheres were prepared using the membrane emulsification method. Three ionic types of drugs (anionic, cationic and non-ionic) were incorporated into the microspheres, and the effects of sodium alginate concentration and the pressure applied during the dispersing process on the properties o...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040010018128
更新日期：2001-07-01 00:00:00
abstract：:Drug-free polylactic acid (PLA) microspheres were prepared by an emulsification-solvent evaporation technique using different types of protective colloids. The influence of five types of hydrophilic prolymers (polysaccharides, proteins, synthetic cellulose derivatives, synthetic nonionic polymers and surfactants) on t...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652049809006865
更新日期：1998-05-01 00:00:00
abstract：:Liposomes are known to be a potent adjuvant for a wide range of antigens, as well as appropriate antigen carriers for antibody generation response in vivo. In addition, liposomes are effective vehicles for peptides and proteins, thus enhancing their immunogenicity. Considering these properties of liposomes and the ant...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652048.2014.958203
更新日期：2015-01-01 00:00:00
abstract：:This work investigated the means for the efficient encapsulation of muramyl dipeptide (MDP) in poly(epsilon-caprolactone) (PCL) microparticles (MP) by a solvent evaporation method in order to optimize the effect of the adjuvant for oral immunization. Therefore, the influence of MDP concentration in the inner aqueous p...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/026520499288799
更新日期：1999-09-01 00:00:00
abstract：AIM:This study aimed to evaluate the protective effect of flaxseed mucilage on the co-extrusion microencapsulation of Lactobacillus rhamnosus GG. METHODS:Core flow rate, chitosan coating, and flaxseed mucilage concentration were optimised for the microencapsulation of L. rhamnosus. The microbeads were characterised an...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652048.2020.1863490
更新日期：2020-12-28 00:00:00
abstract：:A novel method for preparing the PLGA nanospheres with hydrophilic surface has been designed and characterized. Because of good solubility of tetraglycol in water, PLGA (poly(lactide-co-glycolide)) nanospheres were formed by spraying the PLGA/tetraglycol solution into water. The size of PLGA nanospheres was manipulate...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040400000520
更新日期：2004-11-01 00:00:00
abstract：:This work aimed to investigate the potential effect of cyclodextrin encapsulation on intrinsic ability of daidzein (DAD) and genistein (GEN) to inhibit the glycosaminoglycan (GAG) synthesis in fibroblasts originating from patients with mucopolysaccharidosis (MPS), type II and III. DAD or GEN encapsulation with either ...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652048.2017.1409819
更新日期：2018-01-01 00:00:00
abstract：:The bioavailability of marketed nitrofurantoin capsules was compared to capsules filled with Gantrez-gelatin nitrofurantoin microcapsules of a core:coat ratio of 1:2. The collective results obtained from the analysis of urine samples of five volunteers indicated that nitrofurantoin microcapsules provided a prolonged r...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652048809036727
更新日期：1988-10-01 00:00:00
abstract：:The body distribution of surfactant-coated and non-coated poly(methyl methacrylate) nanoparticles with a size of 131 +/- 30 nm after intravenous injection into rats was investigated. The coating materials were poloxamine 904, poloxamine 908, poloxamine 1508, poloxamer 338, and Brij 35. These materials were preselected...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652049209021219
更新日期：1992-01-01 00:00:00
abstract：:Freeze-drying is an effective way to improve long-term physical stability of nanosuspension in drug delivery applications. Nanosuspension also known as suspension of nanoparticles. In this study, the effect of freeze-drying with different cryoprotectants on the physicochemical characteristics of resveratrol (RSV) nano...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652048.2018.1462416
更新日期：2018-05-01 00:00:00
abstract：:A considerable effort has been spent in the past three decades to investigate various aspects of liposomes as novel drug delivery systems. In 1990, the first amphotericin B (AmB) liposomal preparation (L-AmB) under the brand name AmBisome was introduced into the market by Vestar. The successful marketing of the produc...
journal_title：Journal of microencapsulation
pub_type： 杂志文章,评审
doi：10.3109/02652049809006844
更新日期：1998-03-01 00:00:00
abstract：:The action of two detergents, Triton X-100 and sodium dodecyl sulphate (SDS), on large, unilamellar liposomes was determined as liposome size variation, polydispersity and ability to release a soluble marker from liposomes. Triton X-100 produced stronger effects than SDS. Nevertheless, these differences in behaviour o...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652049009021838
更新日期：1990-04-01 00:00:00
abstract：:Liposomes were introduced first in 1980 for topical drug delivery and since then have attracted considerable interest and generated many speculative claims concerning their potential utility both as a drug carrier and reservoir for controlled release of drugs within various layers of the skin. A number of clinical stu...
journal_title：Journal of microencapsulation
pub_type： 杂志文章,评审
doi：10.3109/02652049309104381
更新日期：1993-04-01 00:00:00
abstract：:An extrusion-based encapsulation process has been developed for making salt grain-sized iron premix for salt fortification. The first step of extrusion agglomeration process has been studied and reported previously. The focus of this study is on the optimisation of the colour-masking and polymer coating steps. Several...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652048.2011.651493
更新日期：2012-01-01 00:00:00
abstract：:Nanoparticles prepared of human serum albumin (HSA) represent promising carriers for drug delivery. Desolvating procedure is a common method to obtain protein-based particles. However process parameters have a great influence on size, size distribution and particle yield of the resulting formulation. Therefore, it is ...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652048.2011.635218
更新日期：2012-01-01 00:00:00
abstract：:Provision and maintenance of adequate concentrations of antibiotics at infection sites is very important in treating highly resistant infections. For diseases like implant related osteomyelitis (IRO) it is best to provide this locally via implanted drug formulations, as systemic administration of the antibiotic may no...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040110065413
更新日期：2002-03-01 00:00:00
abstract：:This article describes the development of a freeze-dried formulation of chitosan (CS) nanocapsules containing docetaxel (DCX) and the evaluation of its efficacy in the NCI-H460 cancer cell line. More specifically, two prototypes of nanocapsules differing in their coating, CS alone or in combination with poloxamer 188 ...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652048.2012.714411
更新日期：2013-01-01 00:00:00
abstract：:Liposomes containing Isovist were prepared by controlled detergent dialysis as well as by reverse phase evaporation. After preparation these liposomes were lyophilized and then submitted to sterilization by ethylene oxide. Prior to lyophilization, trehalose was added as a protective agent to preserve the size of the l...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652048909031168
更新日期：1989-10-01 00:00:00
abstract：:Rosin was esterified with pentaerythritol and intermediate reaction products with different acid values were isolated. Microcapsules containing sulphadiazine were prepared by a solvent evaporation technique using these esters as wall materials. The microcapsules were evaluated for their size, drug content, and release...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652049409040434
更新日期：1994-01-01 00:00:00
abstract：:The real issue in the development of oral controlled release dosage forms is not just to prolong the delivery of drugs but also to prolong the presence of dosage forms in the stomach in order to improve the bioavailability of drugs with a 'narrow absorption window'. In the present study, an anti-ulcer drug, ranitidine...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040801973101
更新日期：2008-08-01 00:00:00
abstract：:Conditions of microencapsulation by in situ polycondensation, using melamine-formaldehyde as wall material, are influenced by the chemical nature of the core to encapsulate. In our study concerning the encapsulation of a photopolymerizable phase containing an electrically charged compound, it was necessary to modify t...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652049309031522
更新日期：1993-07-01 00:00:00
abstract：:The influence of drug particle size on the production of enteric beads by a polymer precipitation technique was investigated. Drug particle dimensions are known to play an important role in most microencapsulation techniques. Bead morphology was greatly influenced by drug particle size, and spherical shaped beads coul...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040050161729
更新日期：2000-11-01 00:00:00
abstract：:This paper discusses the optimization of the solvent evaporation process to produce double-walled (DW) microspheres in a single-step. Five process variables were studied: polymer solution concentration, polymer weight ratio, polymer solution volume ratios, encapsulation temperature, and air flow rate across the top of...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/026520499289149
更新日期：1999-03-01 00:00:00
abstract：CONTEXT:Flavonoids show promising anticancer potential but it is limited due to poor solubility. OBJECTIVE:The present investigation was to prepare Chrysin-Phospholipid complex loaded solid lipid nanoparticles (Ch-PC-SLNs) for improving its encapsulation as compared to that of Chrysin loaded SLNs (Ch-SLNs) and evaluat...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652048.2018.1559369
更新日期：2018-09-01 00:00:00
abstract：:Documented to exhibit cytotoxicity and poor oral bioavailability, alpha-mangostin was encapsulated into PLGA microspheres with optimization of formulation using response surface methodology. Mixed levels of four factors Face central composite design was employed to evaluate critical formulation variables. With 30 runs...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652048.2013.788081
更新日期：2013-01-01 00:00:00
