Abstract：
:The effect of process variables such as nozzle size, flow-rate of dispersed phase, inter-electrode distance, and presence of an acid acceptor and a thickening agent in the dispersed phase, on the production and size distribution of nylon 6-10 microcapsules prepared by interfacial polymerization in a high-voltage electric field was studied. Factors which increased the intensity of the electrostatic forces acting upon the droplets formed, such as increasing nozzle diameter at constant aqueous phase flow-rate and decreasing inter-electrode distance, were found to decrease the capsule size while those which enhanced the availability of the aqueous phase monomer for the polymerization reaction, such as the addition of an acid acceptor and a thickening agent, resulted in an increase in the average size of the capsules obtained. Free flowing capsules and a reduction in the rate of diacid chloride hydrolysis during the process were also obtained with increasing concentration of the thickening agent in the aqueous phase.
journal_name
J Microencapsuljournal_title
Journal of microencapsulationauthors
Etuk BR,Weatherley LR,Murray KRdoi
10.3109/02652049509015288subject
Has Abstractpub_date
1995-03-01 00:00:00pages
173-83issue
2eissn
0265-2048issn
1464-5246journal_volume
12pub_type
杂志文章abstract：:A novel method for preparing the PLGA nanospheres with hydrophilic surface has been designed and characterized. Because of good solubility of tetraglycol in water, PLGA (poly(lactide-co-glycolide)) nanospheres were formed by spraying the PLGA/tetraglycol solution into water. The size of PLGA nanospheres was manipulate...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040400000520
更新日期：2004-11-01 00:00:00
abstract：:The effect of lecithin and starch on viability of alginate encapsulated probiotics was determined at different temperatures. Probiotic organisms (1% v/v>10Log CFU ml(-1)) were encapsulated using alginate (2% w/v), gelatinized starches (2% w/v) and lecithin (0-4% w/v) and stored in sealed containers at 4, 23 and 37 deg...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652040902982183
更新日期：2010-01-01 00:00:00
abstract：:Different classes of excipients with potential for use in the design of novel pelletized formulations manufactured by extrusion-spheronization were examined using factorial experiments. Among the various silicates examined in a model mix with microcrystalline cellulose and lactose wetted with water, kaolin, talc and V...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652049709006817
更新日期：1997-09-01 00:00:00
abstract：:N-lauroyl chitosan (NLCS) conjugates with different degrees of substitution (DS) of lauroyl group were synthesized and used to prepare surface modified poly(lactic-co-glycolic) acid (NLCS-PLGA) nanoparticles via hydrophobic interaction and ionic bond force. NLCS-PLGA nanoparticles had spherical shape with shell-core s...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652048.2013.824515
更新日期：2014-01-01 00:00:00
abstract：:The formation of microcapsules which contain rosemary oil, is herewith described. The process is based on two steps: (a) formation of oil-in-water emulsions, by using lecithin as emulsifier, thus imparting negative charges on the oil droplets; (b) addition of a cationic biopolymer, chitosan, in conditions that favor t...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652049709015332
更新日期：1997-03-01 00:00:00
abstract：:The factors influencing the encapsulation of azathioprine (AZA) into liposomes were investigated to find out the conditions for its optimal entrapment. Similar studies for comparison were also carried out on 6-mercaptopurine (6-MP), of which AZA is a prodrug. AZA and also 6-MP show higher encapsulation efficiencies in...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652049809006875
更新日期：1998-07-01 00:00:00
abstract：:Indomethacin micro-crystals sized approximately 2 microm have been encapsulated with polyelectrolyte multi-layers for the purpose of controlled release. Charged linear poly (dimethyldiallyl ammonium chloride) (PDDA) and poly (styrene sulphonate) (PSS) were alternatively deposited on approximately 2 microm drug micro-c...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040500044972
更新日期：2005-02-01 00:00:00
abstract：:For the preparation of microcapsules using the W/O/W (water in oil in water) emulsion system, it is essential to control various factors such as the dispersed state of the organic phase in the W/O/W emulsion, the difference in the solute concentration between the inner and outer aqueous phases and the volume fraction ...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/0265204031000093096
更新日期：2003-07-01 00:00:00
abstract：:A combined approach based on drug cyclodextrin (CD) complexation and loading into PLGA nanoparticles (NP) has been developed to improve oxaprozin therapeutic efficiency. This strategy exploits the solubilizing and stabilizing properties of CDs and the prolonged-release and targeting properties of PLGA NPs. Drug-loaded...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652040903515508
更新日期：2010-01-01 00:00:00
abstract：:Microencapsulation is almost exclusively performed in batch processes. With today's chemistry increasingly performed in flow reactors, this work aims to realise a continuous reactor setup for the encapsulation of an ester with a polyuria (PU) shell. The generation of an emulsion template is performed in a recirculatio...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652048.2019.1633433
更新日期：2019-06-01 00:00:00
abstract：:In this study microspheres of diclofenac sodium, an anti-inflammatory agent, were prepared by utilizing a natural polysaccharide, chitosan-H. The objective of this investigation was to sustain the action of diclofenac sodium and to show the effect of various conditions on release kinetics. For this reason factorial de...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652049609052903
更新日期：1996-03-01 00:00:00
abstract：:The present research work was aimed at development and optimization of alginate mucoadhesive microspheres of carvedilol for nasal delivery to avoid first pass metabolism and to improve the therapeutic efficacy in the treatment of hypertension and angina pectoris. The microspheres were prepared by a water-in-oil (w/o) ...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040802456726
更新日期：2009-08-01 00:00:00
abstract：:An overview of biodegradable and biocompatible microcapsules and microspheres loaded with neuroactive substances, or cells producing neuroactive substances, and their role as drug delivery systems (DDS) for drug administration to the central nervous system (CNS) is given. In addition, closely related systems are also ...
journal_title：Journal of microencapsulation
pub_type： 杂志文章,评审
doi：10.3109/02652049509087248
更新日期：1995-07-01 00:00:00
abstract：:The release behaviour of aspirin from spray-congealed hydrogenated soybean oil micro-pellets of different sizes was studied. The purpose of this study was to investigate the effect of particle size of micro-pellets on the drug release profile and mechanism. Micro-pellets produced were sieved into several fractions and...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040500100345
更新日期：2005-05-01 00:00:00
abstract：:Sequential interpenetrating networks of poly(methacrylic acid) and poly(vinyl alcohol) have been prepared and cross-linked with glutaraldehyde to obtain pH sensitive microspheres by a water-in-oil emulsification method. Microspheres have been used to deliver the chosen model anti-inflammatory drug viz., ibuprofen to t...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040801896435
更新日期：2008-06-01 00:00:00
abstract：:To prepare the sustained release vitamin C carriers, vitamin C was successfully encapsulated in tripolyphosphate (TPP) cross-linked chitosan (TPP-chitosan) microspheres by the spray-drying method at different manufacturing conditions. Manufacturing parameters (inlet temperature, liquid flow rate, chitosan concentratio...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040500435436
更新日期：2006-02-01 00:00:00
abstract：:Palmatine (PM) is a potent anti-infective agent used to treat eye diseases. However, PM is less effective for ocular application due to short residence time within the eyes. This study aimed to develop a cationic lipid emulsions (CLEs) for ophthalmic delivery of PM and evaluate its suitability in infection treatment. ...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652048.2016.1248512
更新日期：2016-12-01 00:00:00
abstract：:The aim was to study the effect of the type of polymer solvent on characteristics of microspheres produced by spray drying. The water-soluble model protein, bovine serum albumin (BSA) was microencapsulated into biodegradable poly(D,L-lactic acid) using the following 10 different polymer solvents: acetaldehyde dimethyl...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652049509051129
更新日期：1995-01-01 00:00:00
abstract：PURPOSE:To develop a stable and reproducible modified release pellet formulation containing ibuprofen. METHODS:Using extrusion-spheronization technology to produce pellets. RESULTS:The percentage yield, size distribution and overall pellet shape within the desired size range of 1000-1400 microm was found to be depend...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040500162535
更新日期：2005-09-01 00:00:00
abstract：:The blood-brain barrier (BBB) is the major problem for the treatment of central nervous system diseases. A previous study from our group showed that the brain-targeted chitosan nanoparticles-loaded with large peptide moieties can rapidly cross the barrier and provide neuroprotection. The present study aims to determin...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652048.2017.1375039
更新日期：2017-11-01 00:00:00
abstract：:This work investigated the means for the efficient encapsulation of muramyl dipeptide (MDP) in poly(epsilon-caprolactone) (PCL) microparticles (MP) by a solvent evaporation method in order to optimize the effect of the adjuvant for oral immunization. Therefore, the influence of MDP concentration in the inner aqueous p...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/026520499288799
更新日期：1999-09-01 00:00:00
abstract：:The purpose of this research work was to formulate and systematically evaluate in vitro performance of mucoadhesive microspheres of lacidipine for treatment of pylorospasm. Lacidipine microspheres containing chitosan were prepared by chemical denaturation using glutaraldehyde as a cross-linking agent. The microspheres...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040802376429
更新日期：2009-08-01 00:00:00
abstract：:A new material for the microencapsulation of biological systems was discovered and characterized with regards to the effects of reaction conditions on product yield. By using poly(cyanoacrylate ester), membrane microcapsules were produced with sufficient strength and porosity to be effective in a process environment f...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040110055225
更新日期：2002-11-01 00:00:00
abstract：:To overcome the recurrence problem in bladder tumours; nanoparticles with positive surface charge may improve interaction with biological membranes for intravesical administration. The aim of this study was to design, develop and evaluate (in vitro-in vivo) cationic nanoparticles based on chitosan, poly-L-lysine or po...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652048.2012.668957
更新日期：2012-01-01 00:00:00
abstract：:The objective of this study was to prepare floating theophylline microspheres with zero order release profiles for use as buoyant reservoirs with increased retention time in the stomach. The microspheres were prepared by a modified emulsion-solvent evaporation method using a polymer mixture of cellulose acetate butyra...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652049809008255
更新日期：1998-11-01 00:00:00
abstract：:Aim: A novel folated pluronic F127 (FA-F127) was synthesised, so as to modify liposomes with FA group on the surface, and evaluate the effects of FA-F127 modification on the properties of the modified liposomes.Methods: FA was linked to one end of pluronic F127, via the terminal OH group, to obtain FA-F127 and the str...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652048.2020.1720030
更新日期：2020-05-01 00:00:00
abstract：:The aim of this study was to investigate how glass transition temperature (Tg) influenced polymer microsphere formation and degradation of three chemically, similar novel salicylatebased poly(anhydride-esters): poly[1,6-bis(o-carboxyphenoxy)hexanoate] (CPH), Tg = 59 degrees C; poly[1,8-bis(o-carboxyphenoxy)octanoate] ...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040600776481
更新日期：2006-09-01 00:00:00
abstract：:The degradation of polybutylcyanoacrylate (PBC) and polyhexylcyanoacrylate (PHC) nanoparticles, together with their association with and toxicity towards isolated hepatocytes, were determined. Nanoparticles were not taken up by rat hepatocytes at a significant level. The LD50S of PBC and PHC nanoparticles towards hepa...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652048409049364
更新日期：1984-07-01 00:00:00
abstract：AIM:This study aimed to evaluate the protective effect of flaxseed mucilage on the co-extrusion microencapsulation of Lactobacillus rhamnosus GG. METHODS:Core flow rate, chitosan coating, and flaxseed mucilage concentration were optimised for the microencapsulation of L. rhamnosus. The microbeads were characterised an...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652048.2020.1863490
更新日期：2020-12-28 00:00:00
abstract：:Latex particles coated with either amino or carboxyl groups were labelled with 99mTc. Two labelling methods were used: (1) direct labelling with tin reduction and (2) ligand exchange with tin pyrophosphate. Labelling efficiency and the radiochemical impurities were determined by thin-layer chromatography. Effect of [S...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652049309015313
更新日期：1993-01-01 00:00:00
