Abstract：
:Haemoglobin (Hb) was encapsulated into liposomes as a blood substitute by a freeze-thaw method. The encapsulation efficiency was affected by the Hb/lipid ratio, starting Hb concentration, pH and salt concentration. Liposome-encapsulated haemoglobin (LEH) prepared by this method contains 5-10 mM Hb with 4-10 per cent methaemoglobin (Met-Hb), depending on the starting Hb/lipid ratio and Met-Hb content. The encapsulated Hb has the same absorption spectrum as free Hb and shows oxygen-dissociation characteristics similar to normal red blood cells when 2,3-diphosphoglycerate is co-entrapped in the liposomes. LEH exhibited some leakage, which was greatly reduced by sequential extrusions of LEH through polycarbonate membranes (1.0 and 0.45 microns). Stability of LEH was studied using different Hb preparations, and antioxidants of lipids or/and Hb either at 4 or 37 degrees C. alpha-tocopherol or butylated hydroxytoluene, antioxidants of lipids, inhibited not only the peroxidation of liposomes but also Hb oxidation. Among antioxidants of Hb, NADH was most effective in preventing the oxidation of Hb. Glutathione had a moderate preventive effect. However, catalase had no effect and ascorbate accelerated the oxidation of Hb. Glucose and glutathione decreased the oxidation of Hb only in the Hb preparation obtained by hypotonic lysing, not in that by toluene lysing. These results indicate that the Met-Hb reductase system in the latter is lost or inactivated during isolation.
journal_name
J Microencapsuljournal_title
Journal of microencapsulationauthors
Liu L,Yonetani Tdoi
10.3109/02652049409034258subject
Has Abstractpub_date
1994-07-01 00:00:00pages
409-21issue
4eissn
0265-2048issn
1464-5246journal_volume
11pub_type
杂志文章abstract：:Captopril microcapsules were prepared using four different viscosity grades of ethyl cellulose (core: wall ratios 1:1, 1:2 and 1:3) by temperature induced coacervation from cyclohexane. In vitro dissolution studies in 0.1 M hydrochloric acid showed that the drug release was dependent on the core to wall ratio, the vis...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652049009028424
更新日期：1990-01-01 00:00:00
abstract：:Microcapsules containing fragrant oil (Foral oil) were synthesized via the in situ polymerization method using melamine-formaldehyde (M-F) as a wall material. The encapsulation efficiency and other physical properties were analysed with varying formaldehyde/melamine (F/M) mole ratio and pH of emulsion medium. The pH o...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040210140472
更新日期：2002-09-01 00:00:00
abstract：:Chronic osteomyelitis is still the cause of many problems in orthopaedics in terms of therapy and infection persistence. Four-to-six week systemic antibiotic therapy is required along with bone and soft tissue debridement in the therapy of chronic osteomyelitis. Prolonged-release local antibiotic therapy has been take...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/0265204031000154179
更新日期：2003-11-01 00:00:00
abstract：:The objective of this study was to prepare a microparticulate drug delivery system being based on a new thiomer, namely a chitosan 2-iminothiolane conjugate (chitosan-TBA conjugate). Due to thiol groups being immobilized on chitosan, chitosan-TBA conjugate exhibits improved mucoadhesive and permeation enhancing proper...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040500162220
更新日期：2005-08-01 00:00:00
abstract：:The effect of process variables such as nozzle size, flow-rate of dispersed phase, inter-electrode distance, and presence of an acid acceptor and a thickening agent in the dispersed phase, on the production and size distribution of nylon 6-10 microcapsules prepared by interfacial polymerization in a high-voltage elect...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652049509015288
更新日期：1995-03-01 00:00:00
abstract：:The factors influencing the encapsulation of azathioprine (AZA) into liposomes were investigated to find out the conditions for its optimal entrapment. Similar studies for comparison were also carried out on 6-mercaptopurine (6-MP), of which AZA is a prodrug. AZA and also 6-MP show higher encapsulation efficiencies in...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652049809006875
更新日期：1998-07-01 00:00:00
abstract：:The development of microparticulate food particles for marine suspension-feeders is discussed with respect to the difficulties of nutrient delivery in the aquatic environment and to feeding and digestion in crustacea and bivalve molluscs. Loss of nutrients from particles suspended in seawater must be minimized by eith...
journal_title：Journal of microencapsulation
pub_type： 杂志文章,评审
doi：10.3109/02652048509049572
更新日期：1985-01-01 00:00:00
abstract：:To improve poor water solubility of cyclosporine A (CsA), hydroxypropyl-beta-cyclodextrin (HPβCD) was incorporated into the nanoparticle formulation. Solid complexes of CsA with HPβCD in different ratios were prepared by the kneading method. CsA containing alone or in combination with HPβCD in poly-lactide-co-glycolid...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652048.2012.668961
更新日期：2012-01-01 00:00:00
abstract：:Catechin (CT) is natural molecule proved for antidiabetic activity. Clinical application of CT is highly restricted because of its low bioavailability and ineffectiveness in in vivo conditions. Therefore, the main objective of the present investigation was to formulate CT-loaded Eudragit RS 100 microparticles and eval...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652048.2017.1337248
更新日期：2017-06-01 00:00:00
abstract：:Oil-containing polyterephthalamide microcapsules were synthesized by the interfacial polymerization of an oil-soluble monomer (terephthaloyl dichloride, TDC) and a mixture of two water-soluble monomers (diethylenetriamine, DETA, and 1, 6-hexamethylenediamine, HMDA). The influence of several synthesis parameters (e.g. ...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040110055243
更新日期：2001-11-01 00:00:00
abstract：:Bioavailability of oral drugs can be limited by an intestinal excretion process mediated by P-glycoprotein (P-gp). Polyethylene glycol (PEG) is a known P-gp inhibitor. Dispersion of Famotidine (a P-gp substrate) within PEGylated nanoparticles (NPs) was used to improve its oral bioavailability. In this work, we evaluat...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652048.2017.1290155
更新日期：2017-02-01 00:00:00
abstract：:The development of solid lipid nanoparticles (SLN) containing all-trans retinoic acid (RA) is an interesting approach to topical treatment of acne. SLN has potential for controlled release and follicular penetration, which can reduce adverse effects in comparison with conventional formulations. However, the encapsulat...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040701288519
更新日期：2007-08-01 00:00:00
abstract：:The blood-brain barrier (BBB) is the major problem for the treatment of central nervous system diseases. A previous study from our group showed that the brain-targeted chitosan nanoparticles-loaded with large peptide moieties can rapidly cross the barrier and provide neuroprotection. The present study aims to determin...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652048.2017.1375039
更新日期：2017-11-01 00:00:00
abstract：:In the previous report, microencapsulation of lipase employing a (w/o)/w multiple phase emulsion technique, with 2:1 polystyrene (PS)-SBR mixture being used as a wall material, was proposed. Catalysis of the encapsulated enzyme was investigated, and the hydrolysis of triacetin (triglyceride of acetic acid) was success...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652048909019911
更新日期：1989-07-01 00:00:00
abstract：:Drug-free polylactic acid (PLA) microspheres were prepared by an emulsification-solvent evaporation technique using different types of protective colloids. The influence of five types of hydrophilic prolymers (polysaccharides, proteins, synthetic cellulose derivatives, synthetic nonionic polymers and surfactants) on t...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652049809006865
更新日期：1998-05-01 00:00:00
abstract：:Clinical applications of Sesbania grandiflora bark extract (SGE) are limited because of its poor water solubility and stability. SGE was loaded in micelles of Pluronics. In vitro and in vivo antibacterial and toxicity tests were investigated using broth dilution and silkworm model. Aqueous solubility of SGE was improv...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652048.2017.1284277
更新日期：2017-02-01 00:00:00
abstract：:The objective of this work was to prepare and evaluate ketoprofen-loaded albumin microspheres for intramuscular administration. Microspheres were prepared by emulsion cross-linking method using a 2(3) factorial design and the effect of different factors on entrapment efficiency was determined. Microspheres were evalua...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040802420367
更新日期：2009-08-01 00:00:00
abstract：:The purpose of present research work was to develop mucoadhesive microspheres for nasal delivery with the aim to avoid hepatic first-pass metabolism, improve therapeutic efficacy and enhance residence time. For the treatment of migraine, hydroxypropyl methylcellulose (HPMC) K4M and K15M based microspheres containing s...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652040802685241
更新日期：2009-12-01 00:00:00
abstract：:Insulin-loaded solid lipid nanoparticles (SLN), obtained by the solvent-in-water emulsion-diffusion technique, were produced using isovaleric acid (IVA) as organic phase, glyceryl mono-stearate (GMS) as lipid, soy lecithin and sodium taurodeoxycholate (TDC) as emulsifiers. IVA, a partially water-miscible solvent with ...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040701532981
更新日期：2007-11-01 00:00:00
abstract：:Sub-100-nm nanoparticles were prepared from beta-lactoglobulin (BLG) with a narrow size distribution by a desolvation method using glutaraldehyde for cross-linking. With pre-heating of the BLG solution to 60 degrees C and subsequent pH readjustment to 9.0, nanoparticles of 59 +/- 5 nm were obtained with improved unifo...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040601035143
更新日期：2006-12-01 00:00:00
abstract：:Palmatine (PM) is a potent anti-infective agent used to treat eye diseases. However, PM is less effective for ocular application due to short residence time within the eyes. This study aimed to develop a cationic lipid emulsions (CLEs) for ophthalmic delivery of PM and evaluate its suitability in infection treatment. ...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652048.2016.1248512
更新日期：2016-12-01 00:00:00
abstract：:In recent years, wormwood has been successfully applied in various fields, such as flavouring agent, plant dye, insect repellent and medical product. Wormwood oil encapsulated microcapsules with continuous release behaviours would be further applied in the health care textiles. Here, wormwood oil encapsulated microcap...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652048.2020.1749320
更新日期：2020-06-01 00:00:00
abstract：:Cis-parinaric acid is fluorescent when partioned into a lipid environment and its fluorescence is destroyed upon reaction with free radicals. In our study 1-palmitoyl-2-parinoyl-phosphatidylcholine (cis-PnA) has been used to monitor the time-course of liposomal lipid peroxidation, using reverse-phase evaporation vesic...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652049609026029
更新日期：1996-07-01 00:00:00
abstract：:Alginate bead containing calcium carbonate particle were prepared by dropping the suspension of alginate/calcium carbonate (4/1, w/w) into aqueous solution of CaCl(2) (0.1 M). The pH-dependent release property of the bead was observed for 12 h using blue dextran as a model drug. The release increased up to 4 h in a sa...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040701657820
更新日期：2007-12-01 00:00:00
abstract：:The aim of this study was to develop and characterize diclofenac sodium loaded-cellulose acetate butyrate microparticles in order to obtain a controlled-release system. The influence of the type of polymer, the volume and composition of the internal phase, drug loading, surfactant concentration and additive added on m...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040701747928
更新日期：2008-02-01 00:00:00
abstract：:Gelatin/gum arabic (GA) microcapsules were prepared by a convenient one step complex coacervation, in which TiO2 nanoparticles modified by stearic acid (SA) and homodispersed in tetrachloroethylene (TCE) were encapsulated. The modified TiO2 was characterized by Fourier transform infrared spectroscopy (FT-IR), dynamic ...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040802127806
更新日期：2009-02-01 00:00:00
abstract：:Microencapsulation of ketoprofen using Eudragit RS and RL (acrylic resins) was investigated based on the dispersion system of ketoprofen-containing acetone in liquid paraffin. Aluminium tristearate was used as an additive for the preparation of microcapsules. Good reproducibility was observed in the microencapsulation...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652048609021799
更新日期：1986-10-01 00:00:00
abstract：:This paper describes a novel approach to prepare and characterize calcium-shellac spheres as a carrier of a tooth whitening agent carbamide peroxide. Calcium-shellac spheres were prepared using an extrusion technique based on dropping aqueous ammonium shellac solution into calcium chloride solution. The effects of for...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040802049638
更新日期：2008-12-01 00:00:00
abstract：:Anal fissure is common and painful disease of anorectum. In this study, microparticles containing nifedipine and lidocaine HCl were prepared by spray drying and applied to bio-degradable and bio-stable tampons. Characterization of microparticles was determined by visual analyses, mass yield, particle size measurement,...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652048.2017.1393113
更新日期：2017-12-01 00:00:00
abstract：:The purpose of this study was to design and characterise an oral mucoadhesive micellar drug carrier. In this regard, a mucoadhesive hydrophobic cationic aminocellulose was easily synthesised under mild homogeneous conditions with high yield. The cellulose derivative resulted in strongly improved mucoadhesive propertie...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652048.2015.1046516
更新日期：2015-01-01 00:00:00
