Abstract：
:Capsules have been prepared based on a polyanion blend of sodium alginate and sodium cellulose sulphate, gelled in the presence of calcium chloride and sodium chloride. In a second step a membrane was formed via the addition of polymethylene-co-guanidine (PMCG), an oligocation. A mechanistic study examined the influences of pH, ionic strength, gelation and reaction times as well as the molar mass of the polyanions on the transport and mechanical properties. The ratio of alginate-to-cellulose sulphate in the polyanion blend was also varied and it was found that both mechanical resistance to compression as well as the pore size of the membrane decreased as the percentage of cellulose sulphate was reduced. The maximum mechanical strength was observed to correspond to the minimum in viscosity of the polyanion blend with, for low NaCl levels, a 3:1 alginate:cellulose sulphate level providing the largest resistance to deformation. The ability to decouple the molar mass cut-off and mechanical resistance is viewed as an important advantage of alginate/cellulose sulphate/PMCG capsules. Capsules were transplanted into mice to a maximum of 102 days, after which animals were sacrificed and capsules retrieved. Over 90% of the capsules were recovered from the peritoneal cavity with the mechanical properties of the explanted capsules observed to decrease as a function of implantation time, likely as a result of ion exchange. The capsules were, however, relatively free from any rejection which is a quite unusual result for cation containing systems. It is believed that the reason PMCG-based microcapsules function well in vivo is that they provide a net negative charge on the surface. Higher molar mass polycations such as poly-L-lysine provide a net positive charge, inducing inflammation.
journal_name
J Microencapsuljournal_title
Journal of microencapsulationauthors
Renken A,Hunkeler Ddoi
10.1080/02652040601058418subject
Has Abstractpub_date
2007-02-01 00:00:00pages
20-39issue
1eissn
0265-2048issn
1464-5246journal_volume
24pub_type
杂志文章abstract：:The objective of this study was selection of most influential variable for the preparation of gastro adhesive nanoparticles of acyclovir. Effect of formulation and processing variables on various response variables were studied by a Taguchi standard orthogonal array L8 design. Independent variables studied were the am...
journal_title：Journal of microencapsulation
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journal_title：Journal of microencapsulation
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journal_title：Journal of microencapsulation
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abstract：:The effects of different loading procedures of magnetic nanoparticles (MNs) on the structure and physicochemical properties of cisplatin magnetic liposomes were investigated by X-ray diffraction, infrared spectroscopy, transmission electron microscopy, and fluorescence spectroscopy. 1, 2-Dipalmitoyl-sn-glycero-3-Phosp...
journal_title：Journal of microencapsulation
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abstract：:Artificial chylomicron remnants were investigated as a new drug carrier system for the targeting of hepatic parenchymal cells. The emulsions presented here are similar in particle size and composition to natural lipoproteins. The preparations contained triolein, phospholipid, cholesterol and cholesteryl oleate. Egg yo...
journal_title：Journal of microencapsulation
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journal_title：Journal of microencapsulation
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journal_title：Journal of microencapsulation
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journal_title：Journal of microencapsulation
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journal_title：Journal of microencapsulation
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更新日期：1996-07-01 00:00:00
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journal_title：Journal of microencapsulation
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更新日期：2012-01-01 00:00:00
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journal_title：Journal of microencapsulation
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journal_title：Journal of microencapsulation
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更新日期：1995-01-01 00:00:00
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journal_title：Journal of microencapsulation
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journal_title：Journal of microencapsulation
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journal_title：Journal of microencapsulation
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journal_title：Journal of microencapsulation
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更新日期：2015-01-01 00:00:00
abstract：:Grapes (Vitis vinifera) are produced in large amounts worldwide and mostly are used for winemaking. Their untreated wastes are rich in valuable secondary metabolites, such as phenolics. Thus, in this study, white and red wine wastes (Malagouzia and Syrah variety) were investigated for their added value phenolics, whic...
journal_title：Journal of microencapsulation
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abstract：:Ibuprofen-loaded polystyrene microparticles were prepared by the emulsion-solvent evaporation process from an aqueous system. The effects of different parameters on the drug content and on the release of the drug from the microparticles were investigated. The drug content, in all the formulations, was less than the th...
journal_title：Journal of microencapsulation
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abstract：AIM:This study aimed to evaluate the protective effect of flaxseed mucilage on the co-extrusion microencapsulation of Lactobacillus rhamnosus GG. METHODS:Core flow rate, chitosan coating, and flaxseed mucilage concentration were optimised for the microencapsulation of L. rhamnosus. The microbeads were characterised an...
journal_title：Journal of microencapsulation
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journal_title：Journal of microencapsulation
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abstract：:Low molecular weight heparin (LMWH)-loaded flexible liposomes (flexosomes) were formulated for transdermal delivery, and their physicochemical and pharmacokinetic parameters were compared with LMWH-loaded ethosomes. Flexosomes had similar particle size compared with ethosomes, but their deformability was higher than t...
journal_title：Journal of microencapsulation
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更新日期：2011-01-01 00:00:00
abstract：:The release of fluorescein from polyethylcyanoacrylate (PECA) or polyisobutylcyanoacrylate (PICA) nanoparticles was affected by the surfactants used for the preparation. The different surfactants also modified the molecular weight, size and loading of the nanoparticles. However, these factors were not be responsible f...
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