Abstract：
:This study demonstrates the feasibility of using a single-capillary electrospray (ES) system to generate novel alpha-lipoic acid encapsulated poly(ethylene oxide)-chitosan (ALA/PEO/CS) particles with a monodispersed diameter. Scanning electron microscopic images (SEM) and dynamic light scattering (DLS) results indicate that the ES system can generate either a dry powder or a homogeneous water-based suspension of ALA/PEO/CS particles. The SEM images revealed that the ALA/PEO/CS particles have a spherical shape with a diameter of approximately 707 ± 66.68 nm, and DLS showed that the ALA/PEO/CS particles suspended in deionised water have a diameter of 734.5 nm. In addition, zeta potential studies were performed using a zetasizer instrument and showed positively electric surface potential of 57.7 ± 0.5 mV, which was attributed to chitosan. Based on the DLS and zeta potential studies, we concluded that the excellent dispersity and stability of the ALA/PEO/CS suspension is attributed to the reduction in particle size and electrostatic repulsion between these tiny particles. Finally, we used lipopolysaccharide (LPS)-induced nitrite formation in Raw 264.7 macrophages as a model for in vitro anti-inflammation evaluation. We find that the anti-inflammatory ability of the ALA/PEO/CS particles is superior to that of free ALA solution in macrophage cells, which is attributed to the more efficiently intracellular delivery. The confocal image results prove that the uptake of ALA/PEO/CS particles by the LPS-treated Raw 264.7 macrophages is possibly initiated by the interaction with cell-surface molecules through electrostatic interactions, followed by endocytosis of the attached particles.
journal_name
J Microencapsuljournal_title
Journal of microencapsulationauthors
Bai MY,Hu YMdoi
10.3109/02652048.2013.863395subject
Has Abstractpub_date
2014-01-01 00:00:00pages
373-81issue
4eissn
0265-2048issn
1464-5246journal_volume
31pub_type
杂志文章abstract：:The release behaviour of aspirin from spray-congealed hydrogenated soybean oil micro-pellets of different sizes was studied. The purpose of this study was to investigate the effect of particle size of micro-pellets on the drug release profile and mechanism. Micro-pellets produced were sieved into several fractions and...
journal_title：Journal of microencapsulation
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journal_title：Journal of microencapsulation
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abstract：:A biocompatible emulsification method has been developed for microencapsulation of live cells and enzymes within a calcium alginate matrix. Fabrication of alginate beads was achieved by premixing a sequestering agent (sodium polyphosphate) and the calcium source (calcium sulphate) with the hydrogel monomer prior to th...
journal_title：Journal of microencapsulation
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abstract：:The chitosan microspheres were prepared by a membrane emulsification method with variations of the N2 gas pressure and the chitosan concentration. The pressure of N2 gas was varied within the range from 0.2 x 10(5) to 0.8 x 10(5) Pa at chitosan concentration 1.5 wt%. In addition, the concentration of chitosan was vari...
journal_title：Journal of microencapsulation
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abstract：:Poly(lactic acid) microcapsules of pilocarpine hydrochloride were prepared and evaluated by measuring a miotic effect in rabbits. The microcapsule suspension showed prolongation of miosis and an improved bioavailability when compared with a standard eye dosage form. ...
journal_title：Journal of microencapsulation
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journal_title：Journal of microencapsulation
pub_type： 杂志文章
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journal_title：Journal of microencapsulation
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journal_title：Journal of microencapsulation
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doi：10.1080/02652040010019442
更新日期：2001-05-01 00:00:00
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journal_title：Journal of microencapsulation
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doi：10.3109/02652049609026029
更新日期：1996-07-01 00:00:00
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journal_title：Journal of microencapsulation
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doi：10.3109/02652049109021233
更新日期：1992-04-01 00:00:00
abstract：:The mechanism by which microcapsule aggregation is diminished in the presence of low concentrations of adjunct non-walling polymers such as polyisobutylene (PIB) in organic solvents is uncertain. It is here investigated by phase separation studies employing the non-solvent addition method (cyclohexane) in parallel wit...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652049009028419
更新日期：1990-01-01 00:00:00
abstract：PURPOSE:Naproxen CR tablets have been obtained from its microspheres prepared by coprecipitation with Eudragit L100-55. The purpose of this work was to evaluate the main and interaction effects of deaggregating agent concentration (X1), compression pressure (X2) and amount of precipitating water (X3) on naproxen releas...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040110055630
更新日期：2001-09-01 00:00:00
abstract：:Redox-responsive magnetic protein microcapsules with Fe3O4 magnetic nanoparticles (MNPs) encapsulated inside have been obtained using a facile, cost-effective and fast sonochemical method from hen egg white proteins. Such prepared redox-responsive magnetic hen egg white protein microcapsules (MHEWPMCs) could be easily...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652048.2015.1073389
更新日期：2015-01-01 00:00:00
abstract：:Objective: To improve the water solubility and enhance the oral bioavailability of gambogenic acid (GNA). Methods: GNA-phospholipid complex (GNA-PLC) micelles were successfully prepared by anti-solvent method. Results: The encapsulation efficiency of GNA-PLC micelles can reach 99.33 % (w/w). The average particle size ...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652048.2019.1656294
更新日期：2019-09-01 00:00:00
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journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652048.2016.1144817
更新日期：2016-01-01 00:00:00
abstract：:Microcapsules were prepared through an interfacial cross-linking process using terephthaloylchloride and applied to mixtures of a protein (human serum albumin or gelatin) and a polysaccharide. Their properties were compared with those of microcapsules prepared from the protein alone. Morphological characteristics of m...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652049109069560
更新日期：1991-07-01 00:00:00
abstract：PURPOSE:To develop a stable and reproducible modified release pellet formulation containing ibuprofen. METHODS:Using extrusion-spheronization technology to produce pellets. RESULTS:The percentage yield, size distribution and overall pellet shape within the desired size range of 1000-1400 microm was found to be depend...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040500162535
更新日期：2005-09-01 00:00:00
abstract：:Sub-100-nm nanoparticles were prepared from beta-lactoglobulin (BLG) with a narrow size distribution by a desolvation method using glutaraldehyde for cross-linking. With pre-heating of the BLG solution to 60 degrees C and subsequent pH readjustment to 9.0, nanoparticles of 59 +/- 5 nm were obtained with improved unifo...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040601035143
更新日期：2006-12-01 00:00:00
abstract：:Aim: A novel folated pluronic F127 (FA-F127) was synthesised, so as to modify liposomes with FA group on the surface, and evaluate the effects of FA-F127 modification on the properties of the modified liposomes.Methods: FA was linked to one end of pluronic F127, via the terminal OH group, to obtain FA-F127 and the str...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
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更新日期：2020-05-01 00:00:00
abstract：:In the previous report, microencapsulation of lipase employing a (w/o)/w multiple phase emulsion technique, with 2:1 polystyrene (PS)-SBR mixture being used as a wall material, was proposed. Catalysis of the encapsulated enzyme was investigated, and the hydrolysis of triacetin (triglyceride of acetic acid) was success...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652048909019911
更新日期：1989-07-01 00:00:00
abstract：:This paper describes a novel approach to prepare and characterize calcium-shellac spheres as a carrier of a tooth whitening agent carbamide peroxide. Calcium-shellac spheres were prepared using an extrusion technique based on dropping aqueous ammonium shellac solution into calcium chloride solution. The effects of for...
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pub_type： 杂志文章
doi：10.1080/02652040802049638
更新日期：2008-12-01 00:00:00
abstract：:Chlorogenic acid (CA) is a natural compound used as an antioxidant in the preparation of food, drugs, and cosmetics. Due to their low stability and bioavailability, many researchers have studied the encapsulation of CA in various delivery colloidal systems. The aim of this study was to evaluate the stability of water-...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652048.2018.1559246
更新日期：2018-09-01 00:00:00
abstract：:Biodegradable hollow capsules filled with fluorescently labelled bovine serum albumin (BSA) as a model drug were prepared via layer-by-layer (LbL) self-assembly of type-I collagen (COL) and hyaluronic acid (HA) using calcium carbonate micro-particles and co-precipitation method. Capsules loaded with fluorescein isothi...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652048.2013.834995
更新日期：2014-01-01 00:00:00
abstract：:In this study, we evaluated a system for oral vaccine delivery, consisting of liposomes coated first with a layer of tremella and then with an outer layer of acid-induced alginate. In vitro release studies showed that the triple layer of alginate-tremella-liposomes was more resistant to an acidic pH and modulated the ...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652048.2010.523796
更新日期：2011-01-01 00:00:00
abstract：:Optimum conditions for the preparation of non-magnetic and magnetic microspheres of albumin-globulin mix (alglomix) containing mefenamic acid have been standardized. The effect of various parameters has been investigated with regard to the appearance, yield, drug content and encapsulation efficiency. The physicochemic...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652049109021856
更新日期：1991-01-01 00:00:00
abstract：:Liposomes were introduced first in 1980 for topical drug delivery and since then have attracted considerable interest and generated many speculative claims concerning their potential utility both as a drug carrier and reservoir for controlled release of drugs within various layers of the skin. A number of clinical stu...
journal_title：Journal of microencapsulation
pub_type： 杂志文章,评审
doi：10.3109/02652049309104381
更新日期：1993-04-01 00:00:00
abstract：:The purpose of the present study was to provide further insights on the applicability of microencapsulation using emulsification method, to immobilise Clostridium acetobutylicum ATCC 824 spores, for biobutanol production. The encapsulated spores were revived using heat shock treatment and the fermentation efficiency o...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652048.2015.1017617
更新日期：2015-01-01 00:00:00
abstract：:Hyaluronidase is a protein whose enzymatic activity is successfully employed in extravasation therapy. Taking into account that several proteins (e.g. gelatin and albumin) have been employed as natural polymers for the preparation of microspheres, this work approaches a comprehensive investigation on hyaluronidase inj...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652049809006838
更新日期：1998-01-01 00:00:00
abstract：:Moisture curing type self-healing microcapsules become more attractive, while instability of active core material crippled the efficiency of self-healing behaviour. Polyurea (PU)/melamine formaldehyde (MF) double-layered self-healing microcapsules containing isophorone diisocyanate (IPDI) core with high and stable cor...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652048.2016.1178352
更新日期：2016-06-01 00:00:00
abstract：:The regularities of release of therapeutic antioxidant enzyme superoxide dismutase (SOD) from various alginate-based delivery systems (DS) into simulated gastric and intestinal fluids were determined. The following systems were used: Ca-alginate granules (AG) prepared by various methods, porous carbonate cores with mu...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652048.2016.1206146
更新日期：2016-08-01 00:00:00
